Interferon-induced transmembrane protein 1 (IFITM1) is required for the progression of colorectal cancer
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Ita Novita Sari1,*, Ying-Gui Yang1,*, Lan Thi Hanh Phi1, Hyungjoo Kim2, Moo Jun Baek3, Dongjun Jeong2, Hyog Young Kwon1
1Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Republic of Korea
2Soonchunhyang Medical Science Research Institute, College of Medicine, Soonchunhyang University, Republic of Korea
3Department of Surgery, Department of Pathology, College of Medicine, Soonchunhyang University, Republic of Korea
*These authors contributed equally to this work
Hyog Young Kwon, email: [email protected]
Dongjun Jeong, email: [email protected]
Keywords: IFITM1, colorectal cancer, prognosis, metastasis
Received: June 06, 2016 Accepted: November 07, 2016 Published: November 12, 2016
Interferon-induced transmembrane protein 1 (IFITM1) has been shown to be implicated in multiple cancers, yet little is known about biological significance of IFITM1 in colorectal cancer. Here, we show that IFITM1 is highly expressed in metastatic colorectal cancer cell lines as well as colorectal patient-derived tumor samples, and its expression is associated with a poor prognosis of the disease. Also, IFITM1 depletion resulted in a significant reduction in the mobility of cancer cell lines, whereas ectopic expression of IFITM1 promoted the migration of cancer cells. Epithelial-mesenchymal transition (EMT) signature was dysregulated by both loss and gain of function of IFITM1, which was partially reverted by Caveolin-1 (CAV1). Therefore, these results suggest that IFITM1 may be a prognostic marker and an attractive target to achieve better therapeutic outcomes in colorectal cancer.
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