Oncotarget

Research Papers:

Endoscopic versus laparoscopic resection of gastric gastrointestinal stromal tumors: a multicenter study

Wei-Jie Dai, Gao Liu, Min Wang, Wen-Jie Liu, Wei Song, Xiao-Zhong Yang, Qi-Long Wang, Xiao-Yu Zhang and Zhi-Ning Fan _

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Oncotarget. 2017; 8:11259-11267. https://doi.org/10.18632/oncotarget.13298

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Abstract

Wei-Jie Dai1,*, Gao Liu2,*, Min Wang3,*, Wen-Jie Liu3, Wei Song4, Xiao-Zhong Yang4, Qi-Long Wang5, Xiao-Yu Zhang6, Zhi-Ning Fan7

1Institute of Digestive Endoscopy and Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China; Department of Gastroenterology, Huai'an First People’s Hospital, Nanjing Medical University, Huai’an, China

2Department of Gastrointestinal Surgery, Central Hospital of Enshi Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi, Hubei, China

3Digestive Endoscopy Center, Jiangsu Province Hospital, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China

4Department of Gastroenterology, Huai'an First People’s Hospital, Nanjing Medical University, Huai’an, China

5Department of Clinical Oncology, Huai'an First People’s Hospital, Nanjing Medical University, Huai’an, China

6Division of Gastrointestinal Surgery, Department of General Surgery, The Affiliated Huai'an Hospital of Xuzhou Medical University and The Second People's Hospital of Huai'an, Huai'an, Jiangsu, China

7Institute of Digestive Endoscopy and Medical Center for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University; Digestive Endoscopy Center, Jiangsu Province Hospital, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China

*Co-first authors

Correspondence to:

Zhi-Ning Fan, email: [email protected]

Xiao-Yu Zhang, email: [email protected]

Keywords: minimally invasive, resection, gastric GISTs, endoscopic, laparoscopic

Received: October 09, 2016     Accepted: October 27, 2016     Published: November 11, 2016

ABSTRACT

Despite endoscopic resection has been performed to treat gastric gastrointestinal stromal tumor (GISTs). However, the safety and long-term outcomes remains controversial. This study aims to compare the safety and surgical outcomes of endoscopic versus laparoscopic resection of gastric GISTs. A total of 335 patients that were pathologically confirmed with gastric GISTs (tumor size ≤ 3.5 cm) were surgically treated with endoscopic resection (endoscopic group) or laparoscopic resection (laparoscopic group) in three institutions from March 1, 2011 to October 1 2014. These demographics, tumor characteristics, and outcomes were retrospectively analyzed for identification of outcomes and feasibility of endoscopic or laparoscopic resection. Of 335 patients, 262 and 73 patients underwent endoscopic and laparoscopic resection, respectively. The average tumor size was 1.33±0.78 cm in the endoscopic group and 1.97±0.93 cm in the laparoscopic group. The average operating time was 62.40±36.94 min in the endoscopic group and 112.81±55.69 cm in the laparoscopic group. Days of realimentation was 2.76±1.67 in the endoscopic group and 4.89±2.03 in the laparoscopic group. The average cost was $ 3246.01±1017.61 in the endoscopic group and $ 4884.81±1339.51 in the laparoscopic group. There was no postoperative mortality. Endoscopic resection for gastric GISTs is safe and feasible in tumors ≤ 3.5 cm. Because endoscopic resection showed good results with lower operating time, realimentation days, length of hospital stay and mean total cost, it is a minimally invasive and safe alternative approach which can achieve fast recovery and satisfactory outcomes for appropriately selected patients with gastric GISTs.


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