Clinical Research Papers:

Preoperative peripheral plasma fibrinogen level is an independent prognostic marker in penile cancer

Chengquan Ma, Yaguang zhou, Sufen Zhou, Kun Zhao, Bingxin Lu and Erlin Sun _

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Oncotarget. 2017; 8:12355-12363. https://doi.org/10.18632/oncotarget.12563

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Chengquan Ma1, Yaguang Zhou2, Sufen Zhou3, Kun Zhao4, Bingxin Lu5 and Erlin Sun4

1 Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China

2 Department of Operation Room, The Second Hospital of Tianjin Medical University, Tianjin, China

3 Department of Urology, Jixian People’s Hospital, Tianjin, China

4 Tianjin institute of Urology,The Second Hospital of Tianjin Medical University, Tianjin, China

5 Department of Urology,Tianjin Nankai Hospital, Tianjin, China

Correspondence to:

Erlin Sun, email:

Bingxin Lu, email:

Keywords: penile cancer, biomarker, fibrinogen, prognosis, survival

Received: June 03, 2016 Accepted: October 03, 2016 Published: October 11, 2016


Background and aim: High levels of peripheral plasma fibrinogen have recently been revealed that related to poor clinical prognosis in various types of malignant tumors. The purpose of this research was to identify the prognostic significance of the preoperative peripheral serum fibrinogen level in patients with penile cell carcinoma.

Methods: This retrospective research included 72 penile cancer patients with date about their serum fibrinogen value before surgery who undergone either partial or radical penectomy at The 2nd Hospital of Tianjin Medical University between January 2002 to January 2012. They had a mean follow-up of 30.8 months. To determine the factors that were significant in predicting a patient’s prognosis, univariate and multivariate analyses were performed according to the Cox proportional hazards regression model.

Results: The 5-year cancer specific survival (CSS) rate was 62.4% of patients with preoperative fibrinogen levels below 340 mg/dl and 41.9% for those with higher levels (p = 0.001). Multivariate analysis revealed that the pathological T stage (p < 0.001), tumor grade (p = 0.036), postoperative chemotherapy (p = 0.041), nodal metastasis(p < 0.001), pathological type (p < 0.001) and fibrinogen (p = 0.023) were independent prognostic factors for survival. Patients with low fibrinogen level (<340mg/dl) had significantly longer CSS and the different survival rate were defined using the log-rank test.

Conclusions: The high preoperative peripheral serum fibrinogen level was related to poor survival in penile cancer patients. Fibrinogen may serve as a powerful predictor of CSS in penile cancer patients.

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