Transgenic and gene knockout mice in gastric cancer research

Yannan Jiang and Yingyan Yu _

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Oncotarget. 2017; 8:3696-3710. https://doi.org/10.18632/oncotarget.12467

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Yannan Jiang1 and Yingyan Yu1

1 Department of Surgery of Ruijin Hospital and Shanghai Institute of Digestive Surgery, Shanghai Key Laboratory for Gastric Neoplasms, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Correspondence to:

Yingyan Yu, email:

Keywords: mouse models; gastric cancer; histology

Received: June 15, 2016 Accepted: September 28, 2016 Published: October 04, 2016


Mouse models are useful tool for carcinogenic study. They will greatly enrich the understanding of pathogenesis and molecular mechanisms for gastric cancer. However, only few of mice could develop gastric cancer spontaneously. With the development and improvement of gene transfer technology, investigators created a variety of transgenic and knockout/knockin mouse models of gastric cancer, such as INS-GAS mice and gastrin knockout mice. Combined with helicobacter infection and carcinogens treatment, these transgenic/knockout/knockin mice developed precancerous or cancerous lesions, which are proper for gene function study or experimental therapy. Here we review the progression of genetically engineered mouse models on gastric cancer research, and emphasize the effects of chemical carcinogens or infectious factors on carcinogenesis of genetically modified mouse. We also emphasize the histological examination on mouse stomach. We expect to provide researchers with some inspirations on this field.

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