BMP signaling and its paradoxical effects in tumorigenesis and dissemination

Lijie Zhang; Yingnan Ye; Xinxin Long; Pei Xiao; Xiubao Ren; Jinpu Yu

doi:10.18632/oncotarget.12151

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BMP signaling and its paradoxical effects in tumorigenesis and dissemination

Lijie Zhang, Yingnan Ye, Xinxin Long, Pei Xiao, Xiubao Ren and Jinpu Yu _

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Oncotarget. 2016; 7:78206-78218. https://doi.org/10.18632/oncotarget.12151

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Abstract

Lijie Zhang1, Yingnan Ye2, Xinxin Long1, Pei Xiao1, Xiubao Ren1 and Jinpu Yu1,2

1 Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Prevention and Therapy, Clinical Research Center for Cancer, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, P. R. China

2 Cancer Molecular Diagnostic Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Prevention and Therapy, Clinical Research Center for Cancer, Tianjin, P. R. China

Correspondence to:

Jinpu Yu, email:

Keywords: BMP signaling pathway; tumorigenesis; epithelial–mesenchymal transition; cancer stem cell

Received: April 28, 2016 Accepted: September 14, 2016 Published: September 20, 2016

Abstract

Bone morphogenetic proteins (BMPs) play important roles in embryonic and postnatal development by regulating cell differentiation, proliferation, motility, and survival, thus maintaining homeostasis during organ and tissue development. BMPs can lead to tumorigenesis and regulate cancer progression in different stages. Therefore, we summarized studies on BMP expression, the clinical significance of BMP dysfunction in various cancer types, and the molecular regulation of various BMP-related signaling pathways. We emphasized on the paradoxical effects of BMPs on various aspects of carcinogenesis, including epithelial–mesenchymal transition (EMT), cancer stem cells (CSCs), and angiogenesis. We also reviewed the molecular mechanisms by which BMPs regulate tumor generation and progression as well as potential therapeutic targets against BMPs that might be valuable in preventing tumor growth and invasion.

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BMP signaling and its paradoxical effects in tumorigenesis and dissemination

Abstract