Clinical Research Papers:

Increased hepatic FDG uptake on PET/CT in hepatic sinusoidal obstructive syndrome

Honsoul Kim, Song-Ee Baek, Jieun Moon, Yun Ho Roh, Narae Lee and Arthur Cho _

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Oncotarget. 2016; 7:69024-69031. https://doi.org/10.18632/oncotarget.11816

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Honsoul Kim1,2, Song-Ee Baek1,2, Jieun Moon3, Yun Ho Roh3, Narae Lee4 and Arthur Cho4

1 Department of Radiology, Yonsei University College of Medicine, Seoul, Republic of Korea

2 Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Republic of Korea

3 Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea

4 Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea

Correspondence to:

Arthur Cho, email:

Keywords: syndrome, sinusoidal obstruction syndrome

Received: January 14, 2016 Accepted: August 27, 2016 Published: September 01, 2016


Purpose: Imaging features of sinusoidal obstruction syndrome (SOS), an increasingly common drawback of chemotherapy, were evaluated via 18F-fluorodeoxyglucose (FDG) positron emission tomography computed tomography (PET/CT).

Experimental Design: This retrospective study was approved by our Institutional Review Board, with a waiver of informed consent. FDG PET/CT studies of 35 patients (male, 24; female, 11; median age, 53.2 years) obtained between January, 2005 and December, 2012 were analyzed before and after systemic chemotherapy. Diagnosis of SOS was based on histologic (n=13) or gadoxetic acid-enhanced MRI (n=22) findings. On PET/CT images, ROIs drawn on non-tumorous liver generated mean standardized uptake value (SUVliver). Total lesion glycolysis of liver (TLGliver) was calculated as: SUVliver × CT-derived hepatic volume. Paired t-test was applied to compare changes before and after SOS.

Results: Mean (±standard error [SE]) values of hepatic volume (baseline, 1307.7±46.2 cm3; SOS, 1395.4±41.3 cm3; p=0.004), SUVliver (baseline, 2.08±0.06; SOS, 2.27±0.07; p=0.02), and TLGliver (baseline, 2697.5±114.5; SOS, 3170.2±134.2; p=0.001) significantly increased with development of SOS. In contrast, mean SUVaorta was unchanged (baseline, 1.53±0.04; SOS, 1.50±0.04; p=0.52).

Conclusions: Hepatic FDG uptake on PET/CT intensified after onset of SOS and thus may be an inappropriate reference in this setting, potentially skewing chemotherapeutic responses gauged by lesion-to-liver SUV ratio.

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