Oncotarget

Research Papers:

eIF5B increases ASAP1 expression to promote HCC proliferation and invasion

Zhen-guang Wang, Hao Zheng, Wei Gao, Jun Han, Jing-zhu Cao, Yuan Yang, Shuai Li, Rong Gao, Hui Liu, Ze-ya Pan, Si-yuan Fu, Fang-ming Gu, Hao Xing, Jun-sheng Ni, Hong-li Yan, Hao Ren and Wei-ping Zhou _

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Oncotarget. 2016; 7:62327-62339. https://doi.org/10.18632/oncotarget.11469

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Abstract

Zhen-guang Wang1,*, Hao Zheng1,*, Wei Gao2,*, Jun Han1,*, Jing-zhu Cao5, Yuan Yang1, Shuai Li4, Rong Gao2, Hui Liu1, Ze-ya Pan1, Si-yuan Fu1, Fang-ming Gu1, Hao Xing1, Jun-sheng Ni1, Hong-li Yan3, Hao Ren2, Wei-ping Zhou1

1The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200433, China

2Department of Microbiology, Shanghai Key Laboratory of Medical Biodefense, Second Military Medical University, Shanghai 200433, China

3Department of Laboratory Medicine, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China

4Department of Computer Science, Rensselaer Polytechnic Institute, Troy, NY 12180, USA

5Department of Endocrinology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China

*These authors have contributed equally to this work

Correspondence to:

Wei-ping Zhou, email: [email protected]

Hong-li Yan, email: [email protected]

Hao Ren, email: [email protected]

Keywords: eIF5B, ASAP1, hepatocellular carcinoma, proliferation, invasion

Received: February 04, 2016    Accepted: August 09, 2016    Published: August 22, 2016

ABSTRACT

Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide. Despite the therapeutic advances that have been achieved during the past decade, the molecular pathogenesis underlying HCC remains poorly understood. In this study, we discovered that increased expression eukaryotic translation initiation factor 5B (eIF5B) was significantly correlated with aggressive characteristics and associated with shorter recurrence-free survival (RFS) and overall survival (OS) in a large cohort. We also found that eIF5B promoted HCC cell proliferation and migration in vitro and in vivo partly through increasing ASAP1 expression. Our findings strongly suggested that eIF5B could promote HCC progression and be considered a prognostic biomarker for HCC.


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