Research Papers:

Deregulated FADD expression and phosphorylation in T-cell lymphoblastic lymphoma

José L. Marín-Rubio, María C. de Arriba, María A. Cobos-Fernández, Laura González-Sánchez, Inmaculada Ors, Isabel Sastre, José Fernández-Piqueras and María Villa-Morales _

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Oncotarget. 2016; 7:61485-61499. https://doi.org/10.18632/oncotarget.11370

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José L. Marín-Rubio1,2,3, María C. de Arriba4,5, María A. Cobos-Fernández1,2, Laura González-Sánchez1,2,6, Inmaculada Ors3, Isabel Sastre1, José Fernández-Piqueras1,2,3,6, María Villa-Morales1,2,3,6

1Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain

2IIS-Fundación Jiménez Díaz, Madrid, Spain

3Universidad Autónoma de Madrid, Departamento de Biología, Madrid, Spain

4Universidad Carlos III, Departamento de Bioingeniería, Madrid, Spain

5Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain

6Centro de Investigaciones Biomédicas en Red de Enfermedades Raras (CIBERER), Valencia, Spain

Correspondence to:

María Villa-Morales, email: [email protected]

José Fernández-Piqueras, email: [email protected]

Keywords: T-cell lymphoblastic lymphoma, Fas-associated death domain protein (FADD), expression and phosphorylation, tumor aggressiveness, prognostic marker

Received: April 20, 2016     Accepted: August 11, 2016     Published: August 18, 2016


In the present work, we show that T-cell lymphoblastic lymphoma cells exhibit a reduction of FADD availability in the cytoplasm, which may contribute to impaired apoptosis. In addition, we observe a reduction of FADD phosphorylation that inversely correlates with the proliferation capacity and tumor aggressiveness. The resultant balance between FADD-dependent apoptotic and non-apoptotic abilities may define the outcome of the tumor. Thus, we propose that FADD expression and phosphorylation can be reliable biomarkers with prognostic value for T-LBL stratification.

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