Clinical Research Papers:

Quantitative assessment of CD44 genetic variants and cancer susceptibility in Asians: a meta-analysis

Vishal Chandra, Yun-Mi Lee, Usha Gupta, Balraj Mittal, Jong Joo Kim and Rajani Rai _

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Oncotarget. 2016; 7:74286-74302. https://doi.org/10.18632/oncotarget.10951

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Vishal Chandra1,2,*, Yun-Mi Lee3,*, Usha Gupta4, Balraj Mittal4, Jong Joo Kim3 and Rajani Rai3

1 Department of Biosciences, Integral University, Lucknow, UP, India

2 Stephenson Cancer Center (SCC), University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA

3 School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, Korea

4 Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, India

* These authors have equally contributed to this work

Correspondence to:

Rajani Rai, email:

Jong Joo Kim, email:

Keywords: CD44, single nucleotide polymorphisms (SNP), meta-analysis, cancer, susceptibility

Received: March 30, 2016 Accepted: July 19, 2016 Published: July 29, 2016


CD44 is a well-established cancer stem cell marker playing a crucial role in tumor metastasis, recurrence and chemo-resistance. Genetic variants of CD44 have been shown to be associated with susceptibility to various cancers; however, the results are confounding. Hence, we performed a meta-analysis to clarify these associations more accurately. Overall, rs13347 (T vs. C: OR=1.30, p=<0.004, pcorr=0.032; CT vs. CC: OR=1.29, p=0.015, pcorr=0.047; TT vs. CC: OR=1.77, p=<0.000, pcorr=0.018; CT+TT vs. CC: OR=1.34, p=<0.009, pcorr=0.041) and rs187115 (GG vs. AA: OR=2.34, p=<0.000, pcorr=0.025; AG vs. AA: OR=1.59, p=<0.000, pcorr=0.038; G vs. A allele OR=1.56, p=0.000, pcorr=0.05; AG+GG vs. AA: OR=1.63, p=<0.000, pcorr=0.013) polymorphisms were found to significantly increase the cancer risk in Asians. On the other hand, rs11821102 was found to confer low risk (A vs. G: OR=0.87, p=<0.027, pcorr=0.04; AG vs. GG: OR=0.85, p=<0.017, pcorr=0.01; AG+AA vs. GG: OR=0.86, p=<0.020, pcorr=0.02). Based on our analysis, we suggest significant role of CD44 variants (rs13347, rs187115 and rs11821102) in modulating individual’s cancer susceptibility in Asians. Therefore, these variants may be used as predictive genetic biomarkers for cancer predisposition in Asian populations. However, more comprehensive studies involving other cancers and/or populations, haplotypes, gene-gene and gene-environment interactions are necessary to delineate the role of these variants in conferring cancer risk.

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