Decellularized scaffolds in regenerative medicine

Yaling Yu, Ali Alkhawaji, Yuqiang Ding and Jin Mei _

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Oncotarget. 2016; 7:58671-58683. https://doi.org/10.18632/oncotarget.10945

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Yaling Yu1,2, Ali Alkhawaji3, Yuqiang Ding4 and Jin Mei1,2,4

1 Department of Anatomy, Wenzhou Medical University, Wenzhou, China

2 Institute of Bioscaffold Transplantation and Immunology, Wenzhou Medical University, Wenzhou, China

3 Department of Anatomy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

4 Institute of Neuroscience, Wenzhou Medical University, Wenzhou, China

Correspondence to:

Jin Mei, email:

Keywords: decellularized scaffold, extracellular matrix, regeneration, organ, in vivo/in vitro

Received: February 24, 2016 Accepted: July 18, 2016 Published: July 29, 2016


Allogeneic organ transplantation remains the ultimate solution for end-stage organ failure. Yet, the clinical application is limited by the shortage of donor organs and the need for lifelong immunosuppression, highlighting the importance of developing effective therapeutic strategies. In the field of regenerative medicine, various regenerative technologies have lately been developed using various biomaterials to address these limitations. Decellularized scaffolds, derived mainly from various non-autologous organs, have been proved a regenerative capability in vivo and in vitro and become an emerging treatment approach. However, this regenerative capability varies between scaffolds as a result of the diversity of anatomical structure and cellular composition of organs used for decellularization. Herein, recent advances in scaffolds based on organ regeneration in vivo and in vitro are highlighted along with aspects where further investigations and analyses are needed.

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