Oncotarget

Research Papers:

Clinical significance and diagnostic value of serum CEA, CA19-9 and CA72-4 in patients with gastric cancer

Yao Liang, Wei Wang, Cheng Fang, Seeruttun Sharvesh Raj, Wan-Ming Hu, Qi-Wen Li and Zhi-Wei Zhou _

PDF  |  HTML  |  How to cite

Oncotarget. 2016; 7:49565-49573. https://doi.org/10.18632/oncotarget.10391

Metrics: PDF 2710 views  |   HTML 4485 views  |   ?  


Abstract

Yao Liang1,*, Wei Wang1,*, Cheng Fang1,*, Seeruttun Sharvesh Raj1, Wan-Ming Hu2, Qi-Wen Li3, Zhi-Wei Zhou1

1Department of Gastric and Pancreatic Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China

2Department of Pathological Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China

3Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China

*Co-first authors

Correspondence to:

Zhi-Wei Zhou, email: [email protected]

Keywords: CEA, CA19-9, CA72-4, diagnosis, gastric cancer

Received: February 26, 2016     Accepted: June 03, 2016     Published: July 02, 2016

ABSTRACT

Aims: To evaluate the clinical significance of multiple serum tumor markers (TMs) in the diagnosis of gastric cancer (GC) and establish an accurate discriminant equation to identify the presence of GC.

Results: The serum levels of CEA, CA19-9 and CA72-4 were higher in the GC group than in the control group (P < 0.005). The sensitivity of CEA, CA19-9 and CA72-4 in the diagnosis of GC was 20.1–27.6% individually and increased to 48.2% when they were considered in combination. By using the optimal cut-off value, the sensitivity of CEA, CA19-9 and CA72-4 for the diagnosis of GC was improved but remained unsatisfactory. In addition, we developed the equation Y = –2.185 – 0.015 X1 + 0.180 X2 + 1.226 X3 + 1.505 X4 + 2.749 X5 (X1 = Age, X2 = Sex, X3 =CEA, X4 = CA19-9 and X5 = CA72-4) to predict the presence of GC. This has better accuracy and diagnostic efficiency compared to the combination of TMs.

Methods: Serum carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA19-9)and cancer antigen 72-4 (CA72-4) levels were measured in a total of 2288 patients with GC and 1869 healthy volunteers or patients with benign gastric diseases. We established a diagnostic equation using a portion of the data (training set), and validate its accuracy using the other portion of the data (testing set) .

Conclusions: The diagnostic equation increases the accuracy rate for the diagnosis of GC and will be helpful in the clinic.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 10391