Research Papers:

Vascular endothelial growth factor polymorphisms are associated with osteosarcoma susceptibility

Yuan-Yuan Hu, Xin-Ya Du, Ai-Ling Zhan, Lan Zhou, Qian Jiang, Yu-Ming Niu and Ming Shen _

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Oncotarget. 2016; 7:47711-47719. https://doi.org/10.18632/oncotarget.10278

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Yuan-Yuan Hu1,*, Xin-Ya Du2,*, Ai-Ling Zhan3,*, Lan Zhou4, Qian Jiang1, Yu-Ming Niu1,5, Ming Shen6

1Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China

2Department of Stomatology, People's Hospital of New District Longhua Shenzhen, Shenzhen 518109, China

3Department of Anesthesiology, Central Hospital of Shanghai Songjiang District, Shanghai 201600, China

4Department of Neurology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China

5Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China

6Jiangsu Key Laboratory of Oral Diseases, Department of Dental Implant, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing 210029, China

*These authors contributed equally to this work

Correspondence to:

Yu-Ming Niu, email: [email protected]

Ming Shen, email: [email protected]

Keywords: vascular endothelial growth factor, osteosarcoma, polymorphism, meta-analysis

Received: April 08, 2016     Accepted: June 09, 2016     Published: June 24, 2016


Polymorphisms in the vascular endothelial growth factor (VEGF) gene may contribute to osteosarcoma risk, but the results of previous studies have been inconsistent and inconclusive. We conducted a meta-analysis to assess this association more accurately. Relevant studies were collected systemically from three online English databases. Crude odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the associations of three VEGF gene polymorphisms (+936C/T, –634 G/C, +1612 G/A) with osteosarcoma risk. Seven case-control studies involving 1,350 cases and 1,706 controls were selected for the meta-analysis. The pooled OR indicated that the VEGF +936C/T polymorphism was associated with increased risk of osteosarcoma in a Chinese population (T vs. C: OR = 1.26, 95% CI = 1.12–1.42, P < 0.01; TT vs. CC: OR = 1.70, 95% CI = 1.29–2.24, P < 0.01; CT + TT vs. CC: OR = 1.23, 95% CI = 1.06–1.44, P < 0.01; TT vs. CC + CT: OR = 1.61, 95% CI = 1.23–2.10, P < 0.01). A significant association was also found between the –634 G/C polymorphism and osteosarcoma risk (C vs. G: OR = 0.81, 95% CI = 0.69-0.96, P = 0.01; CC vs. GG: OR = 0.66, 95% CI = 0.48–0.90, P < 0.01; GC + CC vs. GG: OR = 0.80, 95% CI = 0.67–0.96, P = 0.02; CC vs. GG + GC: OR = 0.72, 95% CI = 0.60–0.86, P < 0.01). In sum, our meta-analysis suggests VEGF polymorphisms are associated with osteosarcoma susceptibility in the Chinese population. However, further studies that include different ethnicities and larger populations are needed.

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