The Oncosearch | Oncotarget

C-kit induces epithelialâ€“mesenchymal transition and contributes to salivary adenoid cystic cancer progression Research Paper

Ya-ling Tang, Yun-long Fan, Jian Jiang, Kai-de Li, Min Zheng, Wei Chen, Xiang-rui Ma, Ning Geng, Qian-ming Chen, Yu Chen, Xinhua Liang

Published Jan 6, 2014 · Vol. 5, No. 6 · pp. 1491-1501

Keywords: salivary adenoid cystic cancer, epithelialâ€“mesenchymal transition (EMT), c-kit, cancer stem cell, metastasis

Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis Priority Research Paper

Regina M. Graham, John W. Thompson, Keith A. Webster

Published Dec 29, 2013 · Vol. 5, No. 5 · pp. 1162-1173

Keywords: hypoxia, cancer, xenograft, programmed cell death, bafilomycin A1

Survivin promoter-regulated oncolytic adenovirus with Hsp70 gene exerts effective antitumor efficacy in gastric cancer immunotherapy Research Paper

Weiguo Wang, Weidan Ji, Huanzhang Hu, Juming Ma, Xiaoya Li, Weiqun Mei, Yang Xu, Hui-Zhen Hu, Yan Yan, Qizhe Song, Zhigang Li, Changqing Su

Published Dec 28, 2013 · Vol. 5, No. 1 · pp. 150-160

Keywords: Gastric cancer, Survivin gene, Heat shock protein, Oncolytic adenovirus, Gene therapy

FOXP3 over-expression inhibits melanoma tumorigenesis via effects on proliferation and apoptosis. Research Paper

Bee Shin Tan, Matthew R Anaka, Siddhartha Deb, Claudia Freyer, Lisa M Ebert, Anderly C Chueh, Sheren Al-Obaidi, Andreas Behren, Aparna Jayachandran, Jonathan Cebon, Weisan Chen, John M Mariadason

Published Dec 20, 2013 · Vol. 5, No. 1 · pp. 264-276

Keywords: FOXP3, melanoma, proliferation, apoptosis

Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-ÎºB regulated gene products in multiple myeloma xenograft mouse model Research Paper

Kodappully Sivaraman Siveen, Nurulhuda Mustafa, Feng Li, Radhamani Kannaiyan, Kwang Seok Ahn, Alan Prem Kumar, Wee-Joo Chng, Gautam Sethi

Published Dec 18, 2013 · Vol. 5, No. 3 · pp. 634-648

Keywords: Thymoquinone, MM, bortezomib, apoptosis, NF-ÎºB

Targeting chronic lymphocytic leukemia using CIGB-300, a clinical-stage CK2-specific cell-permeable peptide inhibitor Research Paper

Leila R. Martins, Yasser Perera, Paulo LÃºcio, Maria G. Silva, Silvio E. Perea, JoÃ£o T. Barata

Published Dec 13, 2013 · Vol. 5, No. 1 · pp. 258-263

Keywords: Chronic Lymphocytic Leukemia, CLL, Casein kinase 2, CK2, CIGB-300, Signaling therapies

The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer Research Paper

Zhongwu li, Yanling Wang, Jing Qiu, Qiang Li, Chunping Yuan, Wei Zhang, Dongmiao Wang, Jinhai Ye, Hongbin Jiang, Jianrong Yang, Jie Cheng

Published Dec 7, 2013 · Vol. 4, No. 12 · pp. 2532-2549

Keywords: tongue squamous cell carcinoma, polycomb complex, EZH2, DZNep

Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth Research Paper

Jinyun Chen, Franklin Chung, Guizhi Yang, Minying Pu, Hui Gao, Wei Jiang, Hong Yin, Vladimir Capka, Shailaja Kasibhatla, Bryan Laffitte, Savina Jaeger, Raymond Pagliarini, Yaoyu Chen, Wenlai Zhou

Published Nov 26, 2013 · Vol. 4, No. 12 · pp. 2502-2511

Keywords: PHGDH, breast cancer cells, in vivo

High aldehyde dehydrogenase activity identifies cancer stem cells in human cervical cancer Research Paper

Shuyan Liu, Pengsheng Zheng

Published Nov 25, 2013 · Vol. 4, No. 12 · pp. 2462-2475

Keywords: aldehyde dehydrogenase, cancer stem cells, cervical cancer, self-renewal, chemoresistance

Dietary protein restriction inhibits tumor growth in human xenograft models of prostate and breast cancer Research Paper

Luigi Fontana, Remi M. Adelaiye, Antonella L. Rastelli, Kiersten Marie Miles, Eric Ciamporcero, Valter D. Longo, Holly Nguyen, Robert Vessella, Roberto Pili

Published Nov 23, 2013 · Vol. 4, No. 12 · pp. 2451-2461

Keywords: Protein diet restriction, prostate cancer, breast cancer

Pharmacokinetic modeling optimizes inhibition of the â€˜undruggableâ€™ EWS-FLI1 transcription factor in Ewing Sarcoma Research Paper

Sung-Hyeok Hong, Sarah E. Youbi, S. Peter Hong, Bhaskar Kallakury, Phillip Monroe, Hayriye V. Erkizan, Julie S. Barber-Rotenberg, Peter Houghton, Aykut Ãœren, Jeffrey A. Toretsky

Published Nov 11, 2013 · Vol. 5, No. 2 · pp. 338-350

Keywords: YK-4-279, EWS-FLI1, Ewing Sarcoma, rat xenograft, pharmacokinetic modeling

Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma Research Paper

Jennifer K Wolter, Nikolaus E Wolter, Alvaro Blanch, Teresa Partridge, Lynn Cheng, Daniel A. Morgenstern, Monika Podkowa, David R. Kaplan, Meredith S. Irwin

Published Nov 4, 2013 · Vol. 5, No. 1 · pp. 161-172

Keywords: neuroblastoma, propranolol, beta-adrenergic receptor, p53, p73

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma Research Paper

Anton George Henssen, Theresa Thor, Andrea Odersky, Lukas Heukamp, Nicolai El-Hindy, Anneleen Beckers, Frank Slpeleman, Kristina Althoff, Simon SchÃ¤fers, Alexander Schramm, Ulrich Sure, Gudrun Fleischhack, Angelika Eggert, Johannes Hubertus Schulte

Published Oct 27, 2013 · Vol. 4, No. 11 · pp. 2080-2095

Keywords: BET bromodomains, BRD4, MYC, JQ1, pediatric brain tumors, targeted therapy

Upregulation of adenylate cyclase 3 (ADCY3) increases the tumorigenic potential of cells by activating the CREB pathway Research Paper

Seung-Hyun Hong, Sung-Ho Goh, Sang-Jin Lee, Jung-Ah Hwang, Jieun Lee, Il-Ju Choi, Hyehyun Seo, Jong-Hoon Park, Hiromu Suzuki, Eiichiro Yamamoto, In-Hoo Kim, Jin Sook Jeong, Mi Ha Ju, Dong-Hee Lee, Yeon-Su Lee

Published Sep 30, 2013 · Vol. 4, No. 10 · pp. 1791-1803

Keywords: gastric cancer, adenylate cyclase, tumorigenesis, cAMP/PKA/CREB pathway, promoter methylation

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX Research Paper

Marissa V Powers, Melanie Valenti, Susana Mirander, Alison Maloney, Suzanne A Eccles, George Thomas, Paul A Clarke, Paul Workman

Published Sep 29, 2013 · Vol. 4, No. 11 · pp. 1963-1975

Keywords: 17-AAG, HSP90, BAX, Apoptosis, Colon cancer

Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1 Research Paper

Maria Giovanna Francipane, Eric Lagasse

Published Sep 19, 2013 · Vol. 4, No. 11 · pp. 1948-1962

Keywords: colorectal cancer, cancer stem cells, mTOR, apoptosis

5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft Research Paper

Alexandra Borodovsky, Vafi Salmasi, Sevin Turcan, Armida W. M. Fabius, Gilson Baia, Charles G Eberhart, Jon D. Weingart, Gary L Gallia, Stephen B Baylin, Timothy A Chan, Gregory J Riggins

Published Sep 16, 2013 · Vol. 4, No. 10 · pp. 1737-1747

Keywords: IDH, 5-azacytidine, progressive glioma, xenograft, astrocytoma, methylation

Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis Research Paper

Daniela Loetsch, Elisabeth Steiner, Klaus Holzmann, Sabine Spiegl-Kreinecker, Christine Pirker, Juraj Hlavaty, Helga Petznek, Balazs Hegedus, Tamas Garay, Thomas Mohr, Wolfgang Sommergruber, Walter Berger, Michael Grusch

Published Sep 1, 2013 · Vol. 4, No. 11 · pp. 1904-1918

Keywords: major vault protein, vault particles, glioblastoma multiforme, EGFR, PI3K, migration, invasion

Lung cancer tumorigenicity and drug resistance are maintained through ALDH^hi CD44^hi tumor initiating cells Research Paper

Jing Liu, Zhijie Xiao, Sunny Kit-Man Wong, Vicky Pui-Chi Tin, Ka-Yan Ho, Junwen Wang, Mai-Har Sham, Maria Pik Wong

Published Aug 30, 2013 · Vol. 4, No. 10 · pp. 1698-1711

Keywords: lung cancer, tumor initiating cell, aldehyde dehydrogenase, CD44, drug resistance

Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3Î² phosphorylation and p21 down-regulation in hepatocellular carcinoma Research Paper

Catia Giovannini, Michele Baglioni, Marco Baron Toaldo, Cristiano Ventrucci, Stefania D'Adamo, Mario Cipone, Pasquale Chieco, Laura Gramantieri, Luigi Bolondi

Published Aug 24, 2013 · Vol. 4, No. 10 · pp. 1618-1631

Keywords: ERK, drug resistance, angiogenesis, cell proliferation, Notch3

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C-kit induces epithelialâ€“mesenchymal transition and contributes to salivary adenoid cystic cancer progression Research Paper

Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis Priority Research Paper

Survivin promoter-regulated oncolytic adenovirus with Hsp70 gene exerts effective antitumor efficacy in gastric cancer immunotherapy Research Paper

FOXP3 over-expression inhibits melanoma tumorigenesis via effects on proliferation and apoptosis. Research Paper

Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-ÎºB regulated gene products in multiple myeloma xenograft mouse model Research Paper

Targeting chronic lymphocytic leukemia using CIGB-300, a clinical-stage CK2-specific cell-permeable peptide inhibitor Research Paper

The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer Research Paper

Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth Research Paper

High aldehyde dehydrogenase activity identifies cancer stem cells in human cervical cancer Research Paper

Dietary protein restriction inhibits tumor growth in human xenograft models of prostate and breast cancer Research Paper

Pharmacokinetic modeling optimizes inhibition of the â€˜undruggableâ€™ EWS-FLI1 transcription factor in Ewing Sarcoma Research Paper

Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma Research Paper

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma Research Paper

Upregulation of adenylate cyclase 3 (ADCY3) increases the tumorigenic potential of cells by activating the CREB pathway Research Paper

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX Research Paper

Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1 Research Paper

5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft Research Paper

Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis Research Paper

Lung cancer tumorigenicity and drug resistance are maintained through ALDH^hi CD44^hi tumor initiating cells Research Paper

Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3Î² phosphorylation and p21 down-regulation in hepatocellular carcinoma Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

C-kit induces epithelialâ€“mesenchymal transition and contributes to salivary adenoid cystic cancer progression Research Paper

Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis Priority Research Paper

Survivin promoter-regulated oncolytic adenovirus with Hsp70 gene exerts effective antitumor efficacy in gastric cancer immunotherapy Research Paper

FOXP3 over-expression inhibits melanoma tumorigenesis via effects on proliferation and apoptosis. Research Paper

Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-ÎºB regulated gene products in multiple myeloma xenograft mouse model Research Paper

Targeting chronic lymphocytic leukemia using CIGB-300, a clinical-stage CK2-specific cell-permeable peptide inhibitor Research Paper

The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer Research Paper

Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth Research Paper

High aldehyde dehydrogenase activity identifies cancer stem cells in human cervical cancer Research Paper

Dietary protein restriction inhibits tumor growth in human xenograft models of prostate and breast cancer Research Paper

Pharmacokinetic modeling optimizes inhibition of the â€˜undruggableâ€™ EWS-FLI1 transcription factor in Ewing Sarcoma Research Paper

Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma Research Paper

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma Research Paper

Upregulation of adenylate cyclase 3 (ADCY3) increases the tumorigenic potential of cells by activating the CREB pathway Research Paper

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX Research Paper

Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1 Research Paper

5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft Research Paper

Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis Research Paper

Lung cancer tumorigenicity and drug resistance are maintained through ALDHhi CD44hi tumor initiating cells Research Paper

Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3Î² phosphorylation and p21 down-regulation in hepatocellular carcinoma Research Paper

Lung cancer tumorigenicity and drug resistance are maintained through ALDH^hi CD44^hi tumor initiating cells Research Paper