The Oncosearch | Oncotarget

IGF-1R, a target of let-7b, mediates crosstalk between IRS-2/Akt and MAPK pathways to promote proliferation of oral squamous cell carcinoma Research Paper

Ling Gao, Xiaolong Wang, Xiaofei Wang, Linmei Zhang, Cui Qiang, Suâ€™e Chang, Wenhao Ren, Shaoming Li, Yang Yang, Dongdong Tong, Cheng Chen, Zongfang Li, Tusheng Song, Keqian Zhi, Chen Huang

Published Mar 21, 2014 · Vol. 5, No. 9 · pp. 2562-2574

Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer Research Paper

Jiankun Gao, Asfar S. Azmi, Amro Aboukameel, Michael Kauffman, Sharon Shacham, Abdul-Badi Abou-Samra, Ramzi M. Mohammad

Published Mar 21, 2014 · Vol. 5, No. 11 · pp. 3444-3454

The EF-hand calcium-binding protein tescalcin is a potential oncotarget in colorectal cancer Research Paper

Yun Hee Kang, Seung Ro Han, Jong-Tae Kim, Seon-Jin Lee, Young Il Yeom, Jeong-Ki Min, Chul-Ho Lee, Jae Wha Kim, Suk Ran Yoon, Do-Young Yoon, Kwan Soo Hong, Geum-Sook Hwang, Hee Cheol Kim, Young-Ha Lee, Hee Gu Lee

Published Mar 19, 2014 · Vol. 5, No. 8 · pp. 2149-2160

17Î²-estradiol regulates giant vesicle formation via estrogen receptor-alpha in human breast cancer cells Research Paper

Paul K. Wright, Sarah Bowen Jones, Nicholas Ardern, Rebecca Ward, Robert B. Clarke, Federica Sotgia, Michael P. Lisanti, Goran Landberg, Rebecca Lamb

Published Mar 15, 2014 · Vol. 5, No. 10 · pp. 3055-3065

A novel peptide that inhibits E2F transcription and regresses prostate tumor xenografts Priority Research Paper

Xiaoqi Xie, Nitu Bansal, Tazeem Shaik, John E. Kerrigan, Tamara Minko, Olga Garbuzenko, Emine Ercikan Abali, Nadine Johnson-Farley, Debabrata Banerjee, Kathleen W. Scotto, Joseph R. Bertino

Published Mar 11, 2014 · Vol. 5, No. 4 · pp. 901-907

Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy Research Paper

Bo Cao, Yanfeng Qi, Guanyi Zhang, Duo Xu, Yang Zhan, Xavier Alvarez, Zhiyong Guo, Xueqi Fu, Stephen R. Plymate, Oliver Sartor, Haitao Zhang, Yan Dong

Published Mar 4, 2014 · Vol. 5, No. 6 · pp. 1646-1656

FAAH inhibition enhances anandamide mediated anti-tumorigenic effects in non-small cell lung cancer by downregulating the EGF/EGFR pathway Research Paper

Janani Ravi, Amita Sneh, Konstantin Shilo, Mohd W. Nasser, Ramesh K. Ganju

Published Feb 21, 2014 · Vol. 5, No. 9 · pp. 2475-2486

Keywords: NSCLC, EGFR, Met-F-AEA, FAAH

Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer Research Paper

Shigeru Kawabata, Chun-Te Chiang, Junji Tsurutani, Hideaki Shiga, Matthew L. Arwood, Takefumi Komiya, Joell J. Gills, Regan M. Memmott, Phillip A. Dennis

Published Feb 16, 2014 · Vol. 5, No. 4 · pp. 1062-1070

Keywords: Rapamycin, Pemetrexed, Drug synergy, mTOR, Thymidylate Synthase, Lung Cancer

Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo Research Paper

Anna Goc, Belal Al-Husein Al-Husein, Katerina Katsanevas, Alison Steinbach, Uvette Lou, Harika Sabbineni, David L. DeRemer, Payaningal R. Somanath

Published Feb 15, 2014 · Vol. 5, No. 3 · pp. 775-787

LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway Research Paper

Xiaoyan Li, Qifeng Yang, Haiyang Yu, Lihua Wu, Yuhan Zhao, Cen Zhang, Xuetian Yue, Zhen Liu, Hao Wu, Bruce G. Haffty, Zhaohui Feng, Wenwei Hu

Published Feb 15, 2014 · Vol. 5, No. 3 · pp. 788-801

Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer Research Paper

Francesco Crea, Akira Watahiki, Luca Quagliata, Hui Xue, Larissa Pikor, Abhijit Parolia, Yuwei Wang, Dong Lin, Wan L. Lam, William L. Farrar, Takao Isogai, Rudolf Morant, Serenella Castori-Eppenberger, Kim N. Chi, Yuzhuo Wang, Cheryl D. Helgason

Published Feb 6, 2014 · Vol. 5, No. 3 · pp. 764-774

Prostate cancer-derived CCN3 induces M2 macrophage infiltration and contributes to angiogenesis in prostate cancer microenvironment Research Paper

Po-Chun Chen, Hsu-Chen Cheng, John Wang, Shin-Wei Wang, Huai-Ching Tai, Chiao-Wen Lin, Chih-Hsin Tang

Published Feb 4, 2014 · Vol. 5, No. 6 · pp. 1595-1608

Keywords: CCN3, VEGF, Prostate cancer, M2 macrophage, angiogenesis

Enrichment of circulating melanoma cells (CMCs) using negative selection from patients with metastatic melanoma. Research Paper

Powrnima Joshi, Barbara Jacobs, Adeeb Derakhshan, Lee R. Moore, Paul Elson, Pierre L. Triozzi, Ernest Borden, Maciej Zborowski

Published Feb 3, 2014 · Vol. 5, No. 9 · pp. 2450-2461

Keywords: circulating melanoma cells, CTC, Melan-A, S100B, magnetic separation, negative selection

Synergistic anti-tumor activity of acadesine (AICAR) in combination with the anti-CD20 monoclonal antibody rituximab in in vivo and in vitro models of mantle cell lymphoma Research Paper

Arnau Montraveta, Silvia Xargay-Torrent, MÃ³nica LÃ³pez-Guerra, Laia Rosich, Patricia PÃ©rez-GalÃ¡n, Itziar Salaverria, Silvia BeÃ, Susana G. Kalko, MercÃ¨ de Frias, Clara CampÃ s, GaÃ«l RouÃ©, Dolors Colomer

Published Jan 25, 2014 · Vol. 5, No. 3 · pp. 726-739

Keywords: Acadesine, rituximab, mantle cell lymphoma, xenograft mouse model

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Research Paper

Published Jan 20, 2014 · Vol. 5, No. 13 · pp. 4709-4721

Keywords: resistance, angiogenesis inhibition, vascular endothelial growth factor (VEGF)-signaling, hypoxia, bevacizumab, nintedanib

Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity Research Paper

Jakob H. Mikkelsen, Zachary T. Resch, Bhanu Kalra, Gopal Savjani, Ajay Kumar, Cheryl A. Conover, Claus Oxvig

Published Jan 17, 2014 · Vol. 5, No. 4 · pp. 1014-1025

Keywords: insulin-like growth factor receptor, pregnancy-associated plasma protein-A, proteolytic inhibition, therapeutic antibody, xenograft mouse model

Antitumor activity of the c-Myc inhibitor KSI-3716 in gemcitabine-resistant bladder cancer Research Paper

Ho Kyung Seo, Kyung-Ohk Ahn, Nae-Rae Jung, Ji-Sun Shin, Weon Seo Park, Kang-Hyun Lee, Sang-Jin Lee, Kyung-Chae Jeong

Published Jan 16, 2014 · Vol. 5, No. 2 · pp. 326-337

Keywords: Bladder cancer, c-Myc, inhibitor, gemcitabine, gemcitabine resistance

Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers Research Paper

Ai-Sheng Ho, Chien-Hsin Chen, Chun-Chia Cheng, Chia-Chi Wang, Hua-Ching Lin, Tsai-Yueh Luo, Gi-Shih Lien, Jungshan Chang

Published Jan 14, 2014 · Vol. 5, No. 2 · pp. 473-480

Keywords: biomarker, colorectal cancer, neutrophil elastase

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo Research Paper

John T. Heap, Jan Theys, Muhammad Ehsaan, Aleksandra M Kubiak, Ludwig Dubois, Kim Paesmans, Lieve Van Mellaert, Richard Knox, Sarah A. Kuehne, Phillipe Lambin, Nigel P. Minton

Published Jan 12, 2014 · Vol. 5, No. 7 · pp. 1761-1769

GATA2 as a potential metastasis-driving gene in prostate cancer Research Paper

Yan Ting Chiang, Kendric Wang, Ladan Fazli, Robert Z. Qi, Martin E. Gleave, Colin C. Collins, Peter W. Gout, Yuzhuo Wang

Published Jan 12, 2014 · Vol. 5, No. 2 · pp. 451-461

Keywords: GATA2 gene, prostate cancer, metastasis, focal adhesion, master regulatory gene

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IGF-1R, a target of let-7b, mediates crosstalk between IRS-2/Akt and MAPK pathways to promote proliferation of oral squamous cell carcinoma Research Paper

Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer Research Paper

The EF-hand calcium-binding protein tescalcin is a potential oncotarget in colorectal cancer Research Paper

17Î²-estradiol regulates giant vesicle formation via estrogen receptor-alpha in human breast cancer cells Research Paper

A novel peptide that inhibits E2F transcription and regresses prostate tumor xenografts Priority Research Paper

Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy Research Paper

FAAH inhibition enhances anandamide mediated anti-tumorigenic effects in non-small cell lung cancer by downregulating the EGF/EGFR pathway Research Paper

Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer Research Paper

Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo Research Paper

LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway Research Paper

Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer Research Paper

Prostate cancer-derived CCN3 induces M2 macrophage infiltration and contributes to angiogenesis in prostate cancer microenvironment Research Paper

Enrichment of circulating melanoma cells (CMCs) using negative selection from patients with metastatic melanoma. Research Paper

Synergistic anti-tumor activity of acadesine (AICAR) in combination with the anti-CD20 monoclonal antibody rituximab in in vivo and in vitro models of mantle cell lymphoma Research Paper

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Research Paper

Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity Research Paper

Antitumor activity of the c-Myc inhibitor KSI-3716 in gemcitabine-resistant bladder cancer Research Paper

Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers Research Paper

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo Research Paper

GATA2 as a potential metastasis-driving gene in prostate cancer Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

IGF-1R, a target of let-7b, mediates crosstalk between IRS-2/Akt and MAPK pathways to promote proliferation of oral squamous cell carcinoma Research Paper

Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer Research Paper

The EF-hand calcium-binding protein tescalcin is a potential oncotarget in colorectal cancer Research Paper

17Î²-estradiol regulates giant vesicle formation via estrogen receptor-alpha in human breast cancer cells Research Paper

A novel peptide that inhibits E2F transcription and regresses prostate tumor xenografts Priority Research Paper

Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy Research Paper

FAAH inhibition enhances anandamide mediated anti-tumorigenic effects in non-small cell lung cancer by downregulating the EGF/EGFR pathway Research Paper

Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer Research Paper

Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo Research Paper

LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway Research Paper

Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer Research Paper

Prostate cancer-derived CCN3 induces M2 macrophage infiltration and contributes to angiogenesis in prostate cancer microenvironment Research Paper

Enrichment of circulating melanoma cells (CMCs) using negative selection from patients with metastatic melanoma. Research Paper

Synergistic anti-tumor activity of acadesine (AICAR) in combination with the anti-CD20 monoclonal antibody rituximab in in vivo and in vitro models of mantle cell lymphoma Research Paper

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Research Paper

Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity Research Paper

Antitumor activity of the c-Myc inhibitor KSI-3716 in gemcitabine-resistant bladder cancer Research Paper

Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers Research Paper

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo Research Paper

GATA2 as a potential metastasis-driving gene in prostate cancer Research Paper