The Oncosearch | Oncotarget

The anti-tumor activity of pralatrexate (PDX) correlates with the expression of RFC and DHFR mRNA in preclinical models of multiple myeloma Research Paper

Cristina Kinahan, Michael A. Mangone, Luigi Scotto, Michele Visentin, Enrica Marchi, Hearn Jay Cho, Owen A. O’Connor

Published Feb 26, 2020 · Vol. 11, No. 18 · pp. 1576-1589

Keywords: antifolate, multiple myeloma, pralatrexate, biomarker, reduced folate carrier (RFC)

The anti-tumor activity of pralatrexate (PDX) correlates with the expression of RFC and DHFR mRNA in preclinical models of multiple myeloma Research Paper

Cristina Kinahan, Michael A. Mangone, Luigi Scotto, Michele Visentin, Enrica Marchi, Hearn Jay Cho, Owen A. O’Connor

Published Feb 26, 2020

Keywords: antifolate, multiple myeloma, pralatrexate, biomarker, reduced folate carrier (RFC)

The anti-tumor activity of pralatrexate (PDX) correlates with the expression of RFC and DHFR mRNA in preclinical models of multiple myeloma Research Paper

Cristina Kinahan, Michael A. Mangone, Luigi Scotto, Michele Visentin, Enrica Marchi, Hearn Jay Cho, Owen A. O’Connor

Published Feb 26, 2020

Keywords: antifolate, multiple myeloma, pralatrexate, biomarker, reduced folate carrier (RFC)

EB1-dependent long survival of glioblastoma-grafted mice with the oral tubulin-binder BAL101553 is associated with inhibition of tumor angiogenesis Research Paper

Raphaël Bergès, Aurélie Tchoghandjian, Arnauld Sergé, Stéphane Honoré, Dominique Figarella-Branger, Felix Bachmann, Heidi A. Lane, Diane Braguer

Published Feb 25, 2020 · Vol. 11, No. 8 · pp. 759-774

Keywords: glioblastoma, cancer stem cells, microtubule-targeting agent, experimental cancer therapeutics

SLC25A32 sustains cancer cell proliferation by regulating flavin adenine nucleotide (FAD) metabolism Research Paper

Valeria Santoro, Ilya Kovalenko, Kim Vriens, Stefan Christen, Andreas Bernthaler, Andrea Haegebarth, Sarah-Maria Fendt, Sven Christian

Published Feb 25, 2020 · Vol. 11, No. 8 · pp. 801-812

Keywords: transporter, mitochondria, metabolism, ROS, FAD

Both BRCA1-wild type and -mutant triple-negative breast cancers show sensitivity to the NAE inhibitor MLN4924 which is enhanced upon MLN4924 and cisplatin combination treatment Research Paper

Shrilekha Misra, Xiaoli Zhang, Nissar Ahmad Wani, Steven Sizemore, Alo Ray

Published Feb 25, 2020 · Vol. 11, No. 8 · pp. 784-800

Keywords: triple-negative breast cancer, MLN4924, cisplatin, cell cycle, DNA damage

Subcellular localization of FANCD2 is associated with survival in ovarian carcinoma Research Paper

Sonali Joshi, Shawn Campbell, Jeong Y. Lim, Shannon McWeeney, Adam Krieg, Yukie Bean, Nadja Pejovic, Paulette Mhawech-Fauceglia, Tanja Pejovic

Published Feb 25, 2020 · Vol. 11, No. 8 · pp. 775-783

Keywords: FANCD2, ovarian carcinoma, subcellular localization

CrkL is required for donor T cell migration to GvHD target organs Research Paper

Nathan H. Roy, Mahinbanu Mammadli, Janis K. Burkhardt, Mobin Karimi

Published Feb 24, 2020 · Vol. 11, No. 17 · pp. 1505-1514

Keywords: graft-versus-host disease, CrkL, T cell, migration, inflammation

Mifamurtide and TAM-like macrophages: effect on proliferation, migration and differentiation of osteosarcoma cells Research Paper

Francesca Punzo, Giulia Bellini, Chiara Tortora, Daniela Di Pinto, Maura Argenziano, Elvira Pota, Alessandra Di Paola, Martina Di Martino, Francesca Rossi

Published Feb 18, 2020 · Vol. 11, No. 7 · pp. 687-698

Keywords: macrophage polarization, tumor micro-environment, osteosarcoma, Mifamurtide, MG63

Checkpoint blockade inhibitors enhances the effectiveness of a Listeria monocytogenes-based melanoma vaccine Research Paper

Ryan P. Gilley, Peter H. Dube

Published Feb 18, 2020 · Vol. 11, No. 7 · pp. 740-754

Keywords: cancer immunotherapy, cancer vaccination, checkpoint blockade, melanoma, listeria

Randomized, double-blind trial of F14512, a polyamine-vectorized anticancer drug, compared with etoposide phosphate, in dogs with naturally occurring lymphoma Research Paper

Pierre Boyé, Franck Floch, François Serres, Zacharie Segaoula, Juliette Hordeaux, Quentin Pascal, Virginie Coste, Sandy Courapied, Emmanuel Bouchaert, Agata Rybicka, Claire Mazuy, Laurent Marescaux, Kévyn Geeraert, Corinne Fournel-Fleury, Alain Duhamel, François Machuron, Pierre Ferré, Aurélie Pétain, Nicolas Guilbaud, Dominique Tierny, Bruno Gomes

Published Feb 18, 2020 · Vol. 11, No. 7 · pp. 671-686

Keywords: etoposide phosphate, F14512, non-Hodgkin lymphoma, pet dog model, P-glycoprotein

Identification of biomarkers of immune checkpoint blockade efficacy in recurrent or refractory solid tumor malignancies Research Paper

Richard K. Yang, Yun Qing, Fatima Zahra Jelloul, Mark J. Routbort, Peng Wang, Kenna Shaw, Jiexin Zhang, Jack Lee, L. Jeffrey Medeiros, Scott Kopetz, Michael T. Tetzlaff, Russell R. Broaddus

Published Feb 11, 2020 · Vol. 11, No. 6 · pp. 600-618

Keywords: biomarkers, immunotherapy, mutations, TMB, histology

In vitro studies on CNGRC-CPG2 fusion proteins for ligand-directed enzyme prodrug therapy for targeted cancer therapy Research Paper

Layla Al-mansoori, Sara S. Bashraheel, Alanod D. Al Qahtani, C. David O’Connor, Philip Elsinga, Sayed K. Goda

Published Feb 11, 2020 · Vol. 11, No. 6 · pp. 619-633

Keywords: targeted cancer therapy, carboxypeptidase G2, glucarpidase, ligand directed enzyme prodrug therapy, antibody directed enzyme prodrug therapy

Risk factors for breast cancer brain metastases: a systematic review Review

Lola Koniali, Andreas Hadjisavvas, Anastasia Constantinidou, Kyproula Christodoulou, Yiolanda Christou, Christiana Demetriou, Andreas S. Panayides, Constantinos Pitris, Constantinos S. Pattichis, Eleni Zamba-Papanicolaou, Kyriacos Kyriacou

Published Feb 11, 2020 · Vol. 11, No. 6 · pp. 650-669

Keywords: breast cancer, brain metastases, risk factors, biomarkers

Prognostic value of a three-scale grading system based on combining molecular imaging with ⁶⁸Ga-DOTATATE and ¹⁸F-FDG PET/CT in patients with metastatic gastroenteropancreatic neuroendocrine neoplasias Research Paper

Ioannis Karfis, Gwennaëlle Marin, Hugo Levillain, Stylianos Drisis, Raoul Muteganya, Gabriela Critchi, Loubna Taraji-Schiltz, Carlos Artigas Guix, Leila Shaza, Meriem Elbachiri, Laura Mans, Godelieve Machiels, Alain Hendlisz, Patrick Flamen

Published Feb 11, 2020 · Vol. 11, No. 6 · pp. 589-599

Keywords: gastroenteropancreatic neuroendocrine neoplasias, molecular imaging, prognostic biomarkers, ⁶⁸Ga-DOTATATE PET/CT, ¹⁸F-FDG PET/CT

Tumor secreted ANGPTL2 facilitates recruitment of neutrophils to the lung to promote lung pre-metastatic niche formation and targeting ANGPTL2 signaling affects metastatic disease Research Paper

Manish Charan, Piyush Dravid, Maren Cam, Bhuvana Setty, Ryan D. Roberts, Peter J. Houghton, Hakan Cam

Published Feb 4, 2020 · Vol. 11, No. 5 · pp. 510-522

Keywords: pre-metastatic niche formation, osteosarcoma, ANGPTL2, tumor microenvironment, neutrophils

Sphingomyelin phosphodiesterase 3 methylation and silencing in oral squamous cell carcinoma results in increased migration and invasion and altered stress response Research Paper

James Jabalee, Rebecca Towle, James Lawson, Christopher Dickman, Cathie Garnis

Published Feb 4, 2020 · Vol. 11, No. 5 · pp. 523-534

Keywords: oral squamous cell carcinoma, DNA methylation, SMPD3, erlotinib, cancer progression

Preclinical activity of sacituzumab govitecan (IMMU-132) in uterine and ovarian carcinosarcomas Research Paper

Salvatore Lopez, Emanuele Perrone, Stefania Bellone, Elena Bonazzoli, Burak Zeybek, Chanhee Han, Joan Tymon-Rosario, Gary Altwerger, Gulden Menderes, Anna Bianchi, Luca Zammataro, Aranzazu Manzano, Paola Manara, Elena Ratner, Dan-Arin Silasi, Gloria S. Huang, Masoud Azodi, Peter E. Schwartz, Francesco Raspagliesi, Roberto Angioli, Natalia Buza, Pei Hui, Heather M. Bond, Alessandro D. Santin

Published Feb 4, 2020 · Vol. 11, No. 5 · pp. 560-570

Keywords: sacituzumab govitecan, IMMU-132, uterine carcinosarcoma, trop-2

Identification of molecular targets for the targeted treatment of gastric cancer using dasatinib Research Paper

Raquel Carvalho Montenegro, Alison Howarth, Alessandro Ceroni, Vita Fedele, Batoul Farran, Felipe Pantoja Mesquita, Martin Frejno, Benedict-Tilman Berger, Stephanie Heinzlmeir, Heba Z. Sailem, Roberta Tesch, Daniel Ebner, Stefan Knapp, Rommel Burbano, Bernhard Kuster, Susanne Müller

Published Feb 4, 2020 · Vol. 11, No. 5 · pp. 535-549

Keywords: gastric cancer, dasatinib, biomarker, SRC-kinases, SIK2

Correction: MicroRNA-26b inhibits tumor metastasis by targeting the KPNA2/c-jun pathway in human gastric cancer Correction

Ming-Ming Tsai, Hsiang-Wei Huang, Chia-Siu Wang, Kam-Fai Lee, ChungYing Tsai, Pei-Hsuan Lu, Hsiang-Cheng Chi, Yang-Hsiang Lin, Liang-Mou Kuo, Kwang-Huei Lin

Published Jan 28, 2020

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The anti-tumor activity of pralatrexate (PDX) correlates with the expression of RFC and DHFR mRNA in preclinical models of multiple myeloma Research Paper

The anti-tumor activity of pralatrexate (PDX) correlates with the expression of RFC and DHFR mRNA in preclinical models of multiple myeloma Research Paper

The anti-tumor activity of pralatrexate (PDX) correlates with the expression of RFC and DHFR mRNA in preclinical models of multiple myeloma Research Paper

EB1-dependent long survival of glioblastoma-grafted mice with the oral tubulin-binder BAL101553 is associated with inhibition of tumor angiogenesis Research Paper

SLC25A32 sustains cancer cell proliferation by regulating flavin adenine nucleotide (FAD) metabolism Research Paper

Both BRCA1-wild type and -mutant triple-negative breast cancers show sensitivity to the NAE inhibitor MLN4924 which is enhanced upon MLN4924 and cisplatin combination treatment Research Paper

Subcellular localization of FANCD2 is associated with survival in ovarian carcinoma Research Paper

CrkL is required for donor T cell migration to GvHD target organs Research Paper

Mifamurtide and TAM-like macrophages: effect on proliferation, migration and differentiation of osteosarcoma cells Research Paper

Checkpoint blockade inhibitors enhances the effectiveness of a Listeria monocytogenes-based melanoma vaccine Research Paper

Randomized, double-blind trial of F14512, a polyamine-vectorized anticancer drug, compared with etoposide phosphate, in dogs with naturally occurring lymphoma Research Paper

Identification of biomarkers of immune checkpoint blockade efficacy in recurrent or refractory solid tumor malignancies Research Paper

In vitro studies on CNGRC-CPG2 fusion proteins for ligand-directed enzyme prodrug therapy for targeted cancer therapy Research Paper

Risk factors for breast cancer brain metastases: a systematic review Review

Prognostic value of a three-scale grading system based on combining molecular imaging with ⁶⁸Ga-DOTATATE and ¹⁸F-FDG PET/CT in patients with metastatic gastroenteropancreatic neuroendocrine neoplasias Research Paper

Tumor secreted ANGPTL2 facilitates recruitment of neutrophils to the lung to promote lung pre-metastatic niche formation and targeting ANGPTL2 signaling affects metastatic disease Research Paper

Sphingomyelin phosphodiesterase 3 methylation and silencing in oral squamous cell carcinoma results in increased migration and invasion and altered stress response Research Paper

Preclinical activity of sacituzumab govitecan (IMMU-132) in uterine and ovarian carcinosarcomas Research Paper

Identification of molecular targets for the targeted treatment of gastric cancer using dasatinib Research Paper

Correction: MicroRNA-26b inhibits tumor metastasis by targeting the KPNA2/c-jun pathway in human gastric cancer Correction

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

The anti-tumor activity of pralatrexate (PDX) correlates with the expression of RFC and DHFR mRNA in preclinical models of multiple myeloma Research Paper

The anti-tumor activity of pralatrexate (PDX) correlates with the expression of RFC and DHFR mRNA in preclinical models of multiple myeloma Research Paper

The anti-tumor activity of pralatrexate (PDX) correlates with the expression of RFC and DHFR mRNA in preclinical models of multiple myeloma Research Paper

EB1-dependent long survival of glioblastoma-grafted mice with the oral tubulin-binder BAL101553 is associated with inhibition of tumor angiogenesis Research Paper

SLC25A32 sustains cancer cell proliferation by regulating flavin adenine nucleotide (FAD) metabolism Research Paper

Both BRCA1-wild type and -mutant triple-negative breast cancers show sensitivity to the NAE inhibitor MLN4924 which is enhanced upon MLN4924 and cisplatin combination treatment Research Paper

Subcellular localization of FANCD2 is associated with survival in ovarian carcinoma Research Paper

CrkL is required for donor T cell migration to GvHD target organs Research Paper

Mifamurtide and TAM-like macrophages: effect on proliferation, migration and differentiation of osteosarcoma cells Research Paper

Checkpoint blockade inhibitors enhances the effectiveness of a Listeria monocytogenes-based melanoma vaccine Research Paper

Randomized, double-blind trial of F14512, a polyamine-vectorized anticancer drug, compared with etoposide phosphate, in dogs with naturally occurring lymphoma Research Paper

Identification of biomarkers of immune checkpoint blockade efficacy in recurrent or refractory solid tumor malignancies Research Paper

In vitro studies on CNGRC-CPG2 fusion proteins for ligand-directed enzyme prodrug therapy for targeted cancer therapy Research Paper

Risk factors for breast cancer brain metastases: a systematic review Review

Prognostic value of a three-scale grading system based on combining molecular imaging with 68Ga-DOTATATE and 18F-FDG PET/CT in patients with metastatic gastroenteropancreatic neuroendocrine neoplasias Research Paper

Tumor secreted ANGPTL2 facilitates recruitment of neutrophils to the lung to promote lung pre-metastatic niche formation and targeting ANGPTL2 signaling affects metastatic disease Research Paper

Sphingomyelin phosphodiesterase 3 methylation and silencing in oral squamous cell carcinoma results in increased migration and invasion and altered stress response Research Paper

Preclinical activity of sacituzumab govitecan (IMMU-132) in uterine and ovarian carcinosarcomas Research Paper

Identification of molecular targets for the targeted treatment of gastric cancer using dasatinib Research Paper

Correction: MicroRNA-26b inhibits tumor metastasis by targeting the KPNA2/c-jun pathway in human gastric cancer Correction

Prognostic value of a three-scale grading system based on combining molecular imaging with ⁶⁸Ga-DOTATATE and ¹⁸F-FDG PET/CT in patients with metastatic gastroenteropancreatic neuroendocrine neoplasias Research Paper