The Oncosearch | Oncotarget

Evidence for functional and regulatory cross-talk between Wnt/β-catenin signalling and Mre11–Rad50–Nbs1 complex in the repair of cisplatin-induced DNA cross-links Research Paper

Sanjeev Pasadi, Kalappa Muniyappa

Published Oct 7, 2020 · Vol. 11, No. 44 · pp. 4028-4044

Keywords: cancer, cisplatin resistance, cisplatin-induced DNA crosslinks, Wnt/β-catenin signalling, Mre11–Rad50–Nbs1 complex

Polymerized human hemoglobin increases the effectiveness of cisplatin-based chemotherapy in non-small cell lung cancer Research Paper

Alfredo Lucas, Donald A. Belcher, Carlos Munoz, Alexander T. Williams, Andre F. Palmer, Pedro Cabrales

Published Oct 7, 2020 · Vol. 11, No. 42 · pp. 3770-3781

Keywords: chemotherapy, cisplatin, polymerized hemoglobin, non-small cell lung cancer, hypoxia

Anti-tumor activities of the new oral pan-RAF inhibitor, TAK-580, used as monotherapy or in combination with novel agents in multiple myeloma Research Paper

Rikio Suzuki, Yuka Kitamura, Yoshihiko Nakamura, Hibiki Akashi, Yoshiaki Ogawa, Hiroshi Kawada, Kiyoshi Ando

Published Oct 7, 2020 · Vol. 11, No. 44 · pp. 3984-3997

Keywords: pan-RAF inhibitor, Bim, FOXO3a, bortezomib, lenalidomide

Significance of mesothelin expression in preoperative endoscopic biopsy specimens for colorectal cancer prognosis Research Paper

Takehiro Shiraishi, Eiji Shinto, Masato Yamadera, Ken Nagata, Hitoshi Tsuda, Satsuki Mochizuki, Yoshiki Kajiwara, Koichi Okamoto, Takahiro Einama, Yoji Kishi, Hideki Ueno

Published Oct 6, 2020 · Vol. 11, No. 43 · pp. 3807-3817

Keywords: colorectal cancer, mesothelin, endoscopic biopsy specimen, immunohistochemistry, Pathology

TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic Priority Research Paper

Marie D. Ralff, Aakash Jhaveri, Jocelyn E. Ray, Lanlan Zhou, Avital Lev, Kerry S. Campbell, David T. Dicker, Eric A. Ross, Wafik S. El-Deiry

Published Oct 6, 2020 · Vol. 11, No. 42 · pp. 3753-3769

Keywords: ONC201, TRAIL, breast cancer, death receptors, apoptosis

Targeting an engineered cytokine with interleukin-2 and interleukin-15 activity to the neovasculature of solid tumors Research Paper

Michael R. Mortensen, Jacqueline Mock, Marco Bertolini, Marco Stringhini, Marco Catalano, Dario Neri

Published Oct 6, 2020 · Vol. 11, No. 44 · pp. 3972-3983

Keywords: immunotherapy, immunocytokines, EDB of fibronectin, antibody-cytokine fusion proteins, engineered cytokine

Laser speckle flowgraphy in juxtapapillary retinal capillary hemangioblastoma: a case report on natural course and therapeutic effect Case Report

Mizuho Mitamura, Satoru Kase, Kiriko Hirooka, Susumu Ishida

Published Oct 6, 2020 · Vol. 11, No. 42 · pp. 3800-3804

Keywords: juxtapapillary retinal capillary hemangioblastoma, laser photocoagulation, laser speckle flowgraphy, fluorescein angiography, von Hippel-Lindau disease

A systematic review and meta-analysis of selected toxicity endpoints of alpelisib Review

Misty Shields, Qianxing Mo, Melissa Armitage, Susan C. Sharpe, Ricardo L.B. Costa

Published Oct 5, 2020 · Vol. 11, No. 42 · pp. 3793-3799

Keywords: alpelisib, adverse event, hyperglycemia, rash, diarrhea

Evaluations of CRC2631 toxicity, tumor colonization, and genetic stability in the TRAMP prostate cancer model Research Paper

Robert A. Kazmierczak, Bakul Dhagat-Mehta, Elke Gulden, Li Lee, Lixin Ma, Clintin P. Davis-Stober, Austen A. Barnett, Chiswili Yves Chabu

Published Oct 4, 2020 · Vol. 11, No. 44 · pp. 3943-3958

Keywords: salmonella, cancer targeting, prostate cancer, immunotherapy, TRAMP

What is the role of checkpoint inhibitors in neuroendocrine neoplasms? Editorial

Taymeyah Al-Toubah, Eleonora Pelle, Jonathan Strosberg

Published Oct 4, 2020 · Vol. 11, No. 42 · pp. 3751-3752

Keywords: neuroendocrine neoplasm, neuroendocrine tumor, neuroendocrine carcinoma, immunotherapy, PD-1 inhibitor

MEK is a promising target in the basal subtype of bladder cancer Research Paper

Nathan M. Merrill, Nathalie M. Vandecan, Kathleen C. Day, Phillip L. Palmbos, Mark L. Day, Aaron M. Udager, Sofia D. Merajver, Matthew B. Soellner

Published Oct 3, 2020 · Vol. 11, No. 44 · pp. 3921-3932

Keywords: bladder cancer, drug screen, 3D culture, basal bladder cancer, MEK inhibition

Predictive biomarkers for sacituzumab govitecan efficacy in Trop-2-expressing triple-negative breast cancer Research Paper

Thomas M. Cardillo, Diane L. Rossi, Maria B. Zalath, Donglin Liu, Roberto Arrojo, Robert M. Sharkey, Chien-Hsing Chang, David M. Goldenberg

Published Oct 1, 2020 · Vol. 11, No. 43 · pp. 3849-3862

Keywords: sacituzumab govitecan, Trop-2, biomarker, RAD51, triple-negative breast cancer

Correction: Changes in the cellular immune system and circulating inflammatory markers of stroke patients Correction

Chao Jiang, Weixia Kong, Yuejuan Wang, Wendy Ziai, Qingwu Yang, Fangfang Zuo, Fangfang Li, Yali Wang, Hongwei Xu, Qian Li, Jie Yang, Hong Lu, Jiewen Zhang, Jian Wang

Published Oct 1, 2020

Correction: Inhibition of fibroblast secreted QSOX1 perturbs extracellular matrix in the tumor microenvironment and decreases tumor growth and metastasis in murine cancer models Correction

Tal Feldman, Iris Grossman-Haham, Yoav Elkis, Patrick Vilela, Neta Moskovits, Iris Barshack, Tomer M. Salame, Deborah Fass, Tal Ilani

Published Oct 1, 2020 · Vol. 11, No. 40 · pp. 3687-3687

Combination of copanlisib with cetuximab improves tumor response in cetuximab-resistant patient-derived xenografts of head and neck cancer Research Paper

Konrad Klinghammer, Oliver Politz, Theresa Eder, Raik Otto, Jan-Dirk Raguse, Andreas Albers, Andreas Kaufmann, Ingeborg Tinhofer, Jens Hoffmann, Ulrich Keller, Ulrich Keilholz

Published Oct 1, 2020 · Vol. 11, No. 41 · pp. 3688-3697

Keywords: cetuximab, copanlisib, head and neck squamous cell carcinoma, HPV, patient-derived xenograft model

Identification of international metastatic renal cell carcinoma database consortium (IMDC) intermediate-risk subgroups in patients with metastatic clear-cell renal cell carcinoma Research Paper

Annalisa Guida, Gwénaël Le Teuff, Carolina Alves, Emeline Colomba, Vincenzo Di Nunno, Lisa Derosa, Ronan Flippot, Bernard Escudier, Laurence Albiges

Published Sep 24, 2020 · Vol. 11, No. 49 · pp. 4582-4592

Keywords: metastatic clear-cell renal cell carcinoma, IDMC, intermediate-risk, heterogeneous prognostic, platelets

Correction: Clinical significance and effect of AEG-1 on the proliferation, invasion, and migration of NSCLC: a study based on immunohistochemistry, TCGA, bioinformatics, in vitro and in vivo verification Correction

Yu Zhang, Zu-Yun Li, Xin-Xi Hou, Xiao Wang, Yi-Huan Luo, Yan-Ping Ying, Gang Chen

Published Sep 23, 2020

The pro-apoptotic actions of 2-methoxyestradiol against ovarian cancer involve catalytic activation of PKCδ signaling Research Paper

Purab Pal, Karen Hales, Dale Buchanan Hales

Published Sep 21, 2020 · Vol. 11, No. 40 · pp. 3646-3659

Keywords: 2-methoxyestradiol, ovarian cancer, protein kinase Cδ, p38 MAPK, apoptosis

Evaluation of cancer-derived myocardial impairments using a mouse model Research Paper

Yoshihiro Miyagawa, Shota Nukaga, Takuya Mori, Rina Fujiwara-Tani, Kiyomu Fujii, Shiori Mori, Kei Goto, Shingo Kishi, Takamitsu Sasaki, Chie Nakashima, Hitoshi Ohmori, Isao Kawahara, Yi Luo, Hiroki Kuniyasu

Published Sep 20, 2020 · Vol. 11, No. 41 · pp. 3712-3722

Keywords: cachexia, myocardium, atrophy, mitochondria, oxidative stress

Exploiting the metabolic dependencies of the broad amino acid transporter SLC6A14 Research Paper

Francesca R. Dejure, Joachim Butzer, Ralph K. Lindemann, Balca R. Mardin

Published Sep 18, 2020 · Vol. 11, No. 48 · pp. 4490-4503

Keywords: SLC6A14, metabolic stress, transcriptional regulation, methionine, AMPK

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Evidence for functional and regulatory cross-talk between Wnt/β-catenin signalling and Mre11–Rad50–Nbs1 complex in the repair of cisplatin-induced DNA cross-links Research Paper

Polymerized human hemoglobin increases the effectiveness of cisplatin-based chemotherapy in non-small cell lung cancer Research Paper

Anti-tumor activities of the new oral pan-RAF inhibitor, TAK-580, used as monotherapy or in combination with novel agents in multiple myeloma Research Paper

Significance of mesothelin expression in preoperative endoscopic biopsy specimens for colorectal cancer prognosis Research Paper

TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic Priority Research Paper

Targeting an engineered cytokine with interleukin-2 and interleukin-15 activity to the neovasculature of solid tumors Research Paper

Laser speckle flowgraphy in juxtapapillary retinal capillary hemangioblastoma: a case report on natural course and therapeutic effect Case Report

A systematic review and meta-analysis of selected toxicity endpoints of alpelisib Review

Evaluations of CRC2631 toxicity, tumor colonization, and genetic stability in the TRAMP prostate cancer model Research Paper

What is the role of checkpoint inhibitors in neuroendocrine neoplasms? Editorial

MEK is a promising target in the basal subtype of bladder cancer Research Paper

Predictive biomarkers for sacituzumab govitecan efficacy in Trop-2-expressing triple-negative breast cancer Research Paper

Correction: Changes in the cellular immune system and circulating inflammatory markers of stroke patients Correction

Correction: Inhibition of fibroblast secreted QSOX1 perturbs extracellular matrix in the tumor microenvironment and decreases tumor growth and metastasis in murine cancer models Correction

Combination of copanlisib with cetuximab improves tumor response in cetuximab-resistant patient-derived xenografts of head and neck cancer Research Paper

Identification of international metastatic renal cell carcinoma database consortium (IMDC) intermediate-risk subgroups in patients with metastatic clear-cell renal cell carcinoma Research Paper

Correction: Clinical significance and effect of AEG-1 on the proliferation, invasion, and migration of NSCLC: a study based on immunohistochemistry, TCGA, bioinformatics, in vitro and in vivo verification Correction

The pro-apoptotic actions of 2-methoxyestradiol against ovarian cancer involve catalytic activation of PKCδ signaling Research Paper

Evaluation of cancer-derived myocardial impairments using a mouse model Research Paper

Exploiting the metabolic dependencies of the broad amino acid transporter SLC6A14 Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Evidence for functional and regulatory cross-talk between Wnt/β-catenin signalling and Mre11–Rad50–Nbs1 complex in the repair of cisplatin-induced DNA cross-links Research Paper

Polymerized human hemoglobin increases the effectiveness of cisplatin-based chemotherapy in non-small cell lung cancer Research Paper

Anti-tumor activities of the new oral pan-RAF inhibitor, TAK-580, used as monotherapy or in combination with novel agents in multiple myeloma Research Paper

Significance of mesothelin expression in preoperative endoscopic biopsy specimens for colorectal cancer prognosis Research Paper

TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic Priority Research Paper

Targeting an engineered cytokine with interleukin-2 and interleukin-15 activity to the neovasculature of solid tumors Research Paper

Laser speckle flowgraphy in juxtapapillary retinal capillary hemangioblastoma: a case report on natural course and therapeutic effect Case Report

A systematic review and meta-analysis of selected toxicity endpoints of alpelisib Review

Evaluations of CRC2631 toxicity, tumor colonization, and genetic stability in the TRAMP prostate cancer model Research Paper

What is the role of checkpoint inhibitors in neuroendocrine neoplasms? Editorial

MEK is a promising target in the basal subtype of bladder cancer Research Paper

Predictive biomarkers for sacituzumab govitecan efficacy in Trop-2-expressing triple-negative breast cancer Research Paper

Correction: Changes in the cellular immune system and circulating inflammatory markers of stroke patients Correction

Correction: Inhibition of fibroblast secreted QSOX1 perturbs extracellular matrix in the tumor microenvironment and decreases tumor growth and metastasis in murine cancer models Correction

Combination of copanlisib with cetuximab improves tumor response in cetuximab-resistant patient-derived xenografts of head and neck cancer Research Paper

Identification of international metastatic renal cell carcinoma database consortium (IMDC) intermediate-risk subgroups in patients with metastatic clear-cell renal cell carcinoma Research Paper

Correction: Clinical significance and effect of AEG-1 on the proliferation, invasion, and migration of NSCLC: a study based on immunohistochemistry, TCGA, bioinformatics, in vitro and in vivo verification Correction

The pro-apoptotic actions of 2-methoxyestradiol against ovarian cancer involve catalytic activation of PKCδ signaling Research Paper

Evaluation of cancer-derived myocardial impairments using a mouse model Research Paper

Exploiting the metabolic dependencies of the broad amino acid transporter SLC6A14 Research Paper