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A novel, dual pan-PIM/FLT3 inhibitor SEL24 exhibits broad therapeutic potential in acute myeloid leukemia Research Paper

Wojciech Czardybon, Renata Windak, Aniela GoÅ‚as, MichaÅ‚ GaÅ‚Ä™zowski, Aleksandra Sabiniarz, Izabela Dolata, Magdalena SalwiÅ„ska, PaweÅ‚ Guzik, Magdalena Zawadzka, Ewelina Gabor-Worwa, BoÅ¼ena Winnik, MaÅ‚gorzata Å»urawska, Ewa KolasiÅ„ska, Ewelina Wincza, Marta Bugaj, Monika Danielewicz, Eliza Majewska, Milena Mazan, Grzegorz Dubin, Monika Noyszewska-Kania, Ewa JabÅ‚oÅ„ska, Maciej SzydÅ‚owski, Tomasz Sewastianik, Bartosz PuÅ‚a, Anna Szumera-CieÄ‡kiewicz, Monika Prochorec-Sobieszek, ElÅ¼bieta MÄ…dro, Ewa Lech-MaraÅ„da, Krzysztof Warzocha, Jerome Tamburini, PrzemysÅ‚aw JuszczyÅ„ski, Krzysztof BrzÃ³zka

Published Mar 30, 2018 · Vol. 9, No. 24 · pp. 16917-16931

Improved therapy for medulloblastoma: targeting hedgehog and PI3K-mTOR signaling pathways in combination with chemotherapy Research Paper

Nagendra K. Chaturvedi, Matthew J. Kling, Don W. Coulter, Timothy R. McGuire, Sutapa Ray, Varun Kesherwani, Shantaram S. Joshi, J. Graham Sharp

Published Mar 30, 2018 · Vol. 9, No. 24 · pp. 16619-16633

The JmjN domain as a dimerization interface and a targeted inhibitor of KDM4 demethylase activity Research Paper

May Levin, Michal Stark, Yehuda G. Assaraf

Published Mar 30, 2018 · Vol. 9, No. 24 · pp. 16861-16882

Application of a double-colour upconversion nanofluorescent probe for targeted imaging of mantle cell lymphoma Research Paper

Guang Yang, Yong Cao, Bin Yan, Qiang Lv, Jianbo Yu, Fusheng Zhao, Zhihong Chen, Heran Yang, Mengxi Chen, Zaishun Jin

Published Mar 30, 2018 · Vol. 9, No. 24 · pp. 16758-16774

Small molecule CXCR4 antagonists block the HIV-1 Nef/CXCR4 axis and selectively initiate the apoptotic program in breast cancer cells Research Paper

Ming-Bo Huang, Kyle E. Giesler, Brooke M. Katzman, Anthony R. Prosser, Valarie Truax, Dennis C. Liotta, Lawrence J. Wilson, Vincent C. Bond

Published Mar 30, 2018 · Vol. 9, No. 24 · pp. 16996-17013

Potential therapeutic targets of TP53 gene in the context of its classically canonical functions and its latest non-canonical functions in human cancer Review

Toshimichi Tanaka, Masahiko Watanabe, Keishi Yamashita

Published Mar 23, 2018 · Vol. 9, No. 22 · pp. 16234-16247

Store operated calcium entry is altered by the inhibition of receptors tyrosine kinase Research Paper

NoÃ©mie Emeriau, Marie de Clippele, Philippe Gailly, Nicolas Tajeddine

Published Mar 23, 2018 · Vol. 9, No. 22 · pp. 16059-16073

Relationship between the agonist activity of synthetic ligands of TRAIL-R2 and their cell surface binding modes Research Paper

Neila Chekkat, Caterina M. Lombardo, Cendrine Seguin, Marie-Charlotte Lechner, Florent Dufour, Yves NominÃ©, Marcella De Giorgi, Benoit Frisch, Olivier Micheau, Gilles Guichard, DaniÃ¨le Altschuh, Sylvie Fournel

Published Mar 20, 2018 · Vol. 9, No. 21 · pp. 15566-15578

CDK4/6 inhibition as maintenance and combination therapy for high grade serous ovarian cancer Research Paper

Mangala Iyengar, Patrick Oâ€™Hayer, Alex Cole, Tara Sebastian, Kun Yang, Lan Coffman, Ronald J. Buckanovich

Published Mar 20, 2018 · Vol. 9, No. 21 · pp. 15658-15672

Proteomic analysis defines kinase taxonomies specific for subtypes of breast cancer Research Paper

Kyla A.L. Collins, Timothy J. Stuhlmiller, Jon S. Zawistowski, Michael P. East, Trang T. Pham, Claire R. Hall, Daniel R. Goulet, Samantha M. Bevill, Steven P. Angus, Sara H. Velarde, Noah Sciaky, Tudor I. Oprea, Lee M. Graves, Gary L. Johnson, Shawn M. Gomez

Published Mar 20, 2018 · Vol. 9, No. 21 · pp. 15480-15497

Value-based genomics Review

Jun Gong, Kathy Pan, Marwan Fakih, Sumanta Pal, Ravi Salgia

Published Mar 20, 2018 · Vol. 9, No. 21 · pp. 15792-15815

Selective lysis of breast carcinomas by simultaneous stimulation of sodium channels and blockade of sodium pumps Research Paper

Harry J. Gould III, Jack Norleans, T. David Ward, Chasiti Reid, Dennis Paul

Published Mar 20, 2018 · Vol. 9, No. 21 · pp. 15606-15615

Novel approaches against epidermal growth factor receptor tyrosine kinase inhibitor resistance Review

Carina Heydt, Sebastian Michels, Kenneth S. Thress, Sven Bergner, JÃ¼rgen Wolf, Reinhard Buettner

Published Mar 16, 2018 · Vol. 9, No. 20 · pp. 15418-15434

Targeting multidrug-resistant ovarian cancer through estrogen receptor Î± dependent ATP depletion caused by hyperactivation of the unfolded protein response Priority Research Paper

Xiaobin Zheng, Neal Andruska, Michael J. Lambrecht, Sisi He, Amadeo Parissenti, Paul J. Hergenrother, Erik R. Nelson, David J. Shapiro

Published Mar 13, 2018 · Vol. 9, No. 19 · pp. 14741-14753

Dynamic changes during the treatment of pancreatic cancer Research Paper

Robert A. Wolff, Andrea Wang-Gillam, Hector Alvarez, HervÃ© Tiriac, Dannielle Engle, Shurong Hou, Abigail F. Groff, Anthony San Lucas, Vincent Bernard, Kelvin Allenson, Jonathan Castillo, Dong Kim, Feven Mulu, Jonathan Huang, Bret Stephens, Ignacio I. Wistuba, Matthew Katz, Gauri Varadhachary, YoungKyu Park, James Hicks, Arul Chinnaiyan, Louis Scampavia, Timothy Spicer, Chiara Gerhardinger, Anirban Maitra, David Tuveson, John Rinn, Gregory Lizee, Cassian Yee, Arnold J. Levine

Published Mar 13, 2018 · Vol. 9, No. 19 · pp. 14764-14790

FC-99 ameliorates sepsis-induced liver dysfunction by modulating monocyte/macrophage differentiation via Let-7a related monocytes apoptosis Research Paper

Yarong Zhao, Haiyan Zhu, Haining Wang, Liang Ding, Lizhi Xu, Dai Chen, Sunan Shen, Yayi Hou, Huan Dou

Published Mar 13, 2018 · Vol. 9, No. 19 · pp. 14959-14976

Molecular dissection of engraftment in a xenograft model of myelodysplastic syndromes Research Paper

Mathieu Meunier, Charles Dussiau, Natacha Mauz, Anne Sophie Alary, Christine Lefebvre, Gautier Szymanski, MylÃ¨ne Pezet, FranÃ§oise Blanquet, Olivier Kosmider, Sophie Park

Published Mar 13, 2018 · Vol. 9, No. 19 · pp. 14993-15000

Preclinical characterization of therapeutic antibodies targeted at the carboxy-terminus of Sonic hedgehog Research Paper

Bhairavi Tolani, Ngoc T. Hoang, Luis A. Acevedo, Etienne Giroux Leprieur, Hui Li, Biao He, David M. Jablons

Published Mar 6, 2018 · Vol. 9, No. 18 · pp. 14311-14323

Novel natural withanolides induce apoptosis and inhibit migration of neuroblastoma cells through down regulation of N-myc and suppression of Akt/mTOR/NF-ÎºB activation Research Paper

Chitra Subramanian, Patrick T. Grogan, Valerie P. Opipari, Barbara N. Timmermann, Mark S. Cohen

Published Mar 6, 2018 · Vol. 9, No. 18 · pp. 14509-14523

Mandatory role of HMGA1 in human airway epithelial normal differentiation and post-injury regeneration Research Paper

Haijun Zhang, Jing Yang, Matthew S. Walters, Michelle R. Staudt, Yael Strulovici-Barel, Jacqueline Salit, Jason G. Mezey, Philip L. Leopold, Ronald G. Crystal

Published Mar 6, 2018 · Vol. 9, No. 18 · pp. 14324-14337

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A novel, dual pan-PIM/FLT3 inhibitor SEL24 exhibits broad therapeutic potential in acute myeloid leukemia Research Paper

Improved therapy for medulloblastoma: targeting hedgehog and PI3K-mTOR signaling pathways in combination with chemotherapy Research Paper

The JmjN domain as a dimerization interface and a targeted inhibitor of KDM4 demethylase activity Research Paper

Application of a double-colour upconversion nanofluorescent probe for targeted imaging of mantle cell lymphoma Research Paper

Small molecule CXCR4 antagonists block the HIV-1 Nef/CXCR4 axis and selectively initiate the apoptotic program in breast cancer cells Research Paper

Potential therapeutic targets of TP53 gene in the context of its classically canonical functions and its latest non-canonical functions in human cancer Review

Store operated calcium entry is altered by the inhibition of receptors tyrosine kinase Research Paper

Relationship between the agonist activity of synthetic ligands of TRAIL-R2 and their cell surface binding modes Research Paper

CDK4/6 inhibition as maintenance and combination therapy for high grade serous ovarian cancer Research Paper

Proteomic analysis defines kinase taxonomies specific for subtypes of breast cancer Research Paper

Value-based genomics Review

Selective lysis of breast carcinomas by simultaneous stimulation of sodium channels and blockade of sodium pumps Research Paper

Novel approaches against epidermal growth factor receptor tyrosine kinase inhibitor resistance Review

Targeting multidrug-resistant ovarian cancer through estrogen receptor Î± dependent ATP depletion caused by hyperactivation of the unfolded protein response Priority Research Paper

Dynamic changes during the treatment of pancreatic cancer Research Paper

FC-99 ameliorates sepsis-induced liver dysfunction by modulating monocyte/macrophage differentiation via Let-7a related monocytes apoptosis Research Paper

Molecular dissection of engraftment in a xenograft model of myelodysplastic syndromes Research Paper

Preclinical characterization of therapeutic antibodies targeted at the carboxy-terminus of Sonic hedgehog Research Paper

Novel natural withanolides induce apoptosis and inhibit migration of neuroblastoma cells through down regulation of N-myc and suppression of Akt/mTOR/NF-ÎºB activation Research Paper

Mandatory role of HMGA1 in human airway epithelial normal differentiation and post-injury regeneration Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

A novel, dual pan-PIM/FLT3 inhibitor SEL24 exhibits broad therapeutic potential in acute myeloid leukemia Research Paper

Improved therapy for medulloblastoma: targeting hedgehog and PI3K-mTOR signaling pathways in combination with chemotherapy Research Paper

The JmjN domain as a dimerization interface and a targeted inhibitor of KDM4 demethylase activity Research Paper

Application of a double-colour upconversion nanofluorescent probe for targeted imaging of mantle cell lymphoma Research Paper

Small molecule CXCR4 antagonists block the HIV-1 Nef/CXCR4 axis and selectively initiate the apoptotic program in breast cancer cells Research Paper

Potential therapeutic targets of TP53 gene in the context of its classically canonical functions and its latest non-canonical functions in human cancer Review

Store operated calcium entry is altered by the inhibition of receptors tyrosine kinase Research Paper

Relationship between the agonist activity of synthetic ligands of TRAIL-R2 and their cell surface binding modes Research Paper

CDK4/6 inhibition as maintenance and combination therapy for high grade serous ovarian cancer Research Paper

Proteomic analysis defines kinase taxonomies specific for subtypes of breast cancer Research Paper

Value-based genomics Review

Selective lysis of breast carcinomas by simultaneous stimulation of sodium channels and blockade of sodium pumps Research Paper

Novel approaches against epidermal growth factor receptor tyrosine kinase inhibitor resistance Review

Targeting multidrug-resistant ovarian cancer through estrogen receptor Î± dependent ATP depletion caused by hyperactivation of the unfolded protein response Priority Research Paper

Dynamic changes during the treatment of pancreatic cancer Research Paper

FC-99 ameliorates sepsis-induced liver dysfunction by modulating monocyte/macrophage differentiation via Let-7a related monocytes apoptosis Research Paper

Molecular dissection of engraftment in a xenograft model of myelodysplastic syndromes Research Paper

Preclinical characterization of therapeutic antibodies targeted at the carboxy-terminus of Sonic hedgehog Research Paper

Novel natural withanolides induce apoptosis and inhibit migration of neuroblastoma cells through down regulation of N-myc and suppression of Akt/mTOR/NF-ÎºB activation Research Paper

Mandatory role of HMGA1 in human airway epithelial normal differentiation and post-injury regeneration Research Paper