The Oncosearch | Oncotarget

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Hengyu Lu, Chen Liu, Hung Huynh, Thi Bich Uyen Le, Matthew LaMarche, Morvarid Mohseni, Jeffrey A. Engelman, Peter S. Hammerman, Giordano Caponigro, Huai-Xiang Hao

Published Jan 6, 2020

Keywords: SHP2, FGFR, resistance, feedback activation

Baseline neutrophil-to-lymphocyte ratio and c-reactive protein predict efficacy of treatment with bevacizumab plus paclitaxel for locally advanced or metastatic breast cancer Research Paper

Yoshimasa Miyagawa, Ayako Yanai, Takehiro Yanagawa, Junichi Inatome, Chiyomi Egawa, Arisa Nishimukai, Kaori Takamoto, Takashi Morimoto, Yuichiro Kikawa, Hirofumi Suwa, Tomoe Taji, Ai Yamaguchi, Yuki Okada, Atsushi Sata, Reiko Fukui, Ayako Bun, Hiromi Ozawa, Tomoko Higuchi, Yukie Fujimoto, Michiko Imamura, Yasuo Miyoshi

Published Dec 31, 2019

Keywords: Breast cancer, bevacizumab, neutrophil-to-lymphocyte ratio, c-reactive protein, predictive marker

Baseline neutrophil-to-lymphocyte ratio and c-reactive protein predict efficacy of treatment with bevacizumab plus paclitaxel for locally advanced or metastatic breast cancer Research Paper

Yoshimasa Miyagawa, Ayako Yanai, Takehiro Yanagawa, Junichi Inatome, Chiyomi Egawa, Arisa Nishimukai, Kaori Takamoto, Takashi Morimoto, Yuichiro Kikawa, Hirofumi Suwa, Tomoe Taji, Ai Yamaguchi, Yuki Okada, Atsushi Sata, Reiko Fukui, Ayako Bun, Hiromi Ozawa, Tomoko Higuchi, Yukie Fujimoto, Michiko Imamura, Yasuo Miyoshi

Published Dec 31, 2019

Keywords: Breast cancer, bevacizumab, neutrophil-to-lymphocyte ratio, c-reactive protein, predictive marker

Baseline neutrophil-to-lymphocyte ratio and c-reactive protein predict efficacy of treatment with bevacizumab plus paclitaxel for locally advanced or metastatic breast cancer Research Paper

Yoshimasa Miyagawa, Ayako Yanai, Takehiro Yanagawa, Junichi Inatome, Chiyomi Egawa, Arisa Nishimukai, Kaori Takamoto, Takashi Morimoto, Yuichiro Kikawa, Hirofumi Suwa, Tomoe Taji, Ai Yamaguchi, Yuki Okada, Atsushi Sata, Reiko Fukui, Ayako Bun, Hiromi Ozawa, Tomoko Higuchi, Yukie Fujimoto, Michiko Imamura, Yasuo Miyoshi

Published Dec 31, 2019

Keywords: Breast cancer, bevacizumab, neutrophil-to-lymphocyte ratio, c-reactive protein, predictive marker

Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy Research Paper

Caroline K. Søgaard, Anala Nepal, Voin Petrovic, Animesh Sharma, Nina-Beate Liabakk, Tonje S. Steigedal, Marit Otterlei

Published Dec 31, 2019 · Vol. 10, No. 68 · pp. 7185-7197

Keywords: APIM, multi-targeting therapy, signaling pathways, autophagy, cancer

Schwann cell reprogramming and lung cancer progression: a meta-analysis of transcriptome data Meta-Analysis

Victor Menezes Silva, Jessica Alves Gomes, Liliane Patrícia Gonçalves Tenório, Genilda Castro de Omena Neta, Karen da Costa Paixão, Ana Kelly Fernandes Duarte, Gabriel Cerqueira Braz da Silva, Ricardo Jansen Santos Ferreira, Bruna Del Vechio Koike, Carolinne de Sales Marques, Rafael Danyllo da Silva Miguel, Aline Cavalcanti de Queiroz, Luciana Xavier Pereira, Carlos Alberto de Carvalho Fraga

Published Dec 31, 2019 · Vol. 10, No. 68 · pp. 7288-7307

Keywords: bioinformatic, lung squamous cell carcinoma, lung adenocarcinoma, neuroactive ligand-receptor interaction

Low-dose metronomic cyclophosphamide complements the actions of an intratumoral C-class CpG TLR9 agonist to potentiate innate immunity and drive potent T cell-mediated anti-tumor responses Research Paper

Weng In Leong, Rachel Y. Ames, Jessica M. Haverkamp, Laura Torres, Janine Kline, Ashil Bans, Lauren Rocha, Marilena Gallotta, Cristiana Guiducci, Robert L. Coffman, Mary J. Janatpour

Published Dec 31, 2019 · Vol. 10, No. 68 · pp. 7220-7237

Keywords: TLR9, SD-101, cyclophosphamide, immune therapy, innate immunity

HSP90 overexpression potentiates the B-cell receptor and fibroblast growth factor receptor survival signals in chronic lymphocytic leukemia cells Research Paper

Hasan Mahmud, Mariana Mendez, Bedabrata Mukhopadhyay, Jennifer Holter-Chakrabarty, Asish K. Ghosh

Published Dec 23, 2019 · Vol. 11, No. 22 · pp. 2037-2046

Keywords: CLL, HSP90, BCR, CD79a, PTPN22

EGFR806-CAR T cells selectively target a tumor-restricted EGFR epitope in glioblastoma Research Paper

Ali C. Ravanpay, Juliane Gust, Adam J. Johnson, Lisa S. Rolczynski, Michelle Cecchini, Cindy A. Chang, Virginia J. Hoglund, Rithun Mukherjee, Nicholas A. Vitanza, Rimas J. Orentas, Michael C. Jensen

Published Dec 17, 2019 · Vol. 10, No. 66 · pp. 7080-7095

Keywords: glioblastoma, CAR T cell, EGFR, immunotherapy, mAb806

An innovative diagnostic strategy for the detection of rare molecular targets to select cancer patients for tumor-agnostic treatments Research Paper

Antonio Marchetti, Alessia Di Lorito, Lara Felicioni, Fiamma Buttitta

Published Dec 10, 2019 · Vol. 10, No. 65 · pp. 6957-6968

Keywords: tumor-agnostic treatments, microsatellite instability (MSI), neurotrophic receptor tyrosine kinase (NRTK), tissue microarrays (TMAs), tissue slice arrays (TSAs)

A mouse model of prostate cancer bone metastasis in a syngeneic immunocompetent host Research Paper

Brian W. Simons, Vishal Kothari, Benjamin Benzon, Kamyar Ghabili, Robert Hughes, Jelani C. Zarif, Ashley E. Ross, Paula J. Hurley, Edward M. Schaeffer

Published Dec 3, 2019 · Vol. 10, No. 64 · pp. 6845-6854

Keywords: prostate cancer, bone metastasis, murine model

PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC Priority Research Paper

Thomas B. Davis, Mingli Yang, Heiman Wang, Changgong Lee, Timothy J. Yeatman, W. Jack Pledger

Published Nov 26, 2019 · Vol. 10, No. 63 · pp. 6768-6780

Keywords: colorectal cancer, PTPRS, ERK, SRC, adaptive resistance

A squalamine derivative, NV669, as a novel PTP1B inhibitor: in vitro and in vivo effects on pancreatic and hepatic tumor growth Research Paper

Sylvie Carmona, Jean-Michel Brunel, Rénaté Bonier, Véronique Sbarra, Stéphane Robert, Patrick Borentain, Dominique Lombardo, Eric Mas, René Gerolami

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6651-6667

Keywords: aminosterol, pancreas, liver, PTP1B, cancer

Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2^S310F mutated extramammary Paget’s disease Research Paper

Thierry M. Nordmann, Olivia Messerli-Odermatt, Larissa Meier, Sara Micaletto, Thomas Coppetti, Mirjam Nägeli, Jivko Kamarachev, Ken Kudura, Sandra N. Freiberger, Tamara Rordorf, Joanna Mangana, Ralph Braun, Reinhard Dummer

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6647-6650

Keywords: ERBB2 protein, Paget disease, extramammary, trastuzumab, lapatinib

Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade Research Paper

Sheila Dakhel, Tiziano Ongaro, Baptiste Gouyou, Mattia Matasci, Alessandra Villa, Dario Neri, Samuele Cazzamalli

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6678-6690

Keywords: tumor targeting, antibody-cytokine fusions, targeted-tumor necrosis factor, EDB-fibronectin, intracellular RIPK1-inhibitors

The impact of systemic precision medicine and immunotherapy treatments on brain metastases Review

Rowland H. Han, Gavin P. Dunn, Milan G. Chheda, Albert H. Kim

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6739-6753

Keywords: brain metastases, targeted therapy, precision medicine, immunotherapy, systemic therapy

The long non-coding RNA PCA3: an update of its functions and clinical applications as a biomarker in prostate cancer Review

Ana Emília Goulart Lemos, Aline da Rocha Matos, Luciana Bueno Ferreira, Etel Rodrigues Pereira Gimba

Published Nov 12, 2019 · Vol. 10, No. 61 · pp. 6589-6603

Keywords: PCA3, prostate cancer, biomarker, long non-coding RNA (lncRNA), clinical applications

The multifaceted anti-cancer effects of BRAF-inhibitors Review

Laura Croce, Francesca Coperchini, Flavia Magri, Luca Chiovato, Mario Rotondi

Published Nov 12, 2019 · Vol. 10, No. 61 · pp. 6623-6640

Keywords: BRAF, BRAF-inhibitors, tumor microenvironment, chemokines, CXCL8

The growth of a xenograft breast cancer tumor model with engineered hyaluronan-accumulating stroma is dependent on hyaluronan and independent of CD44 Research Paper

Chunmei Zhao, Benjamin J. Thompson, Kelly Chen, Feng Gao, Barbara Blouw, Mathieu Marella, Susan Zimmerman, Trevor Kimbler, Sheryl Garrovillo, Jesse Bahn, Lei Huang, Zhongdong Huang, H. Michael Shepard, Sanna Rosengren, Christopher D. Thanos, Daniel C. Maneval

Published Nov 12, 2019 · Vol. 10, No. 61 · pp. 6561-6576

Keywords: hyaluronan, breast cancer, xenograft, tumor microenvironment, CD44

Secretome of pleural effusions associated with non-small cell lung cancer (NSCLC) and malignant mesothelioma: therapeutic implications Research Paper

Albert D. Donnenberg, James D. Luketich, Vera S. Donnenberg

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6456-6465

Keywords: pleural effusion, non-small cell lung cancer, malignant mesothelioma, cytokines, IL-6

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Baseline neutrophil-to-lymphocyte ratio and c-reactive protein predict efficacy of treatment with bevacizumab plus paclitaxel for locally advanced or metastatic breast cancer Research Paper

Baseline neutrophil-to-lymphocyte ratio and c-reactive protein predict efficacy of treatment with bevacizumab plus paclitaxel for locally advanced or metastatic breast cancer Research Paper

Baseline neutrophil-to-lymphocyte ratio and c-reactive protein predict efficacy of treatment with bevacizumab plus paclitaxel for locally advanced or metastatic breast cancer Research Paper

Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy Research Paper

Schwann cell reprogramming and lung cancer progression: a meta-analysis of transcriptome data Meta-Analysis

Low-dose metronomic cyclophosphamide complements the actions of an intratumoral C-class CpG TLR9 agonist to potentiate innate immunity and drive potent T cell-mediated anti-tumor responses Research Paper

HSP90 overexpression potentiates the B-cell receptor and fibroblast growth factor receptor survival signals in chronic lymphocytic leukemia cells Research Paper

EGFR806-CAR T cells selectively target a tumor-restricted EGFR epitope in glioblastoma Research Paper

An innovative diagnostic strategy for the detection of rare molecular targets to select cancer patients for tumor-agnostic treatments Research Paper

A mouse model of prostate cancer bone metastasis in a syngeneic immunocompetent host Research Paper

PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC Priority Research Paper

A squalamine derivative, NV669, as a novel PTP1B inhibitor: in vitro and in vivo effects on pancreatic and hepatic tumor growth Research Paper

Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2^S310F mutated extramammary Paget’s disease Research Paper

Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade Research Paper

The impact of systemic precision medicine and immunotherapy treatments on brain metastases Review

The long non-coding RNA PCA3: an update of its functions and clinical applications as a biomarker in prostate cancer Review

The multifaceted anti-cancer effects of BRAF-inhibitors Review

The growth of a xenograft breast cancer tumor model with engineered hyaluronan-accumulating stroma is dependent on hyaluronan and independent of CD44 Research Paper

Secretome of pleural effusions associated with non-small cell lung cancer (NSCLC) and malignant mesothelioma: therapeutic implications Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Baseline neutrophil-to-lymphocyte ratio and c-reactive protein predict efficacy of treatment with bevacizumab plus paclitaxel for locally advanced or metastatic breast cancer Research Paper

Baseline neutrophil-to-lymphocyte ratio and c-reactive protein predict efficacy of treatment with bevacizumab plus paclitaxel for locally advanced or metastatic breast cancer Research Paper

Baseline neutrophil-to-lymphocyte ratio and c-reactive protein predict efficacy of treatment with bevacizumab plus paclitaxel for locally advanced or metastatic breast cancer Research Paper

Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy Research Paper

Schwann cell reprogramming and lung cancer progression: a meta-analysis of transcriptome data Meta-Analysis

Low-dose metronomic cyclophosphamide complements the actions of an intratumoral C-class CpG TLR9 agonist to potentiate innate immunity and drive potent T cell-mediated anti-tumor responses Research Paper

HSP90 overexpression potentiates the B-cell receptor and fibroblast growth factor receptor survival signals in chronic lymphocytic leukemia cells Research Paper

EGFR806-CAR T cells selectively target a tumor-restricted EGFR epitope in glioblastoma Research Paper

An innovative diagnostic strategy for the detection of rare molecular targets to select cancer patients for tumor-agnostic treatments Research Paper

A mouse model of prostate cancer bone metastasis in a syngeneic immunocompetent host Research Paper

PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC Priority Research Paper

A squalamine derivative, NV669, as a novel PTP1B inhibitor: in vitro and in vivo effects on pancreatic and hepatic tumor growth Research Paper

Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2S310F mutated extramammary Paget’s disease Research Paper

Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade Research Paper

The impact of systemic precision medicine and immunotherapy treatments on brain metastases Review

The long non-coding RNA PCA3: an update of its functions and clinical applications as a biomarker in prostate cancer Review

The multifaceted anti-cancer effects of BRAF-inhibitors Review

The growth of a xenograft breast cancer tumor model with engineered hyaluronan-accumulating stroma is dependent on hyaluronan and independent of CD44 Research Paper

Secretome of pleural effusions associated with non-small cell lung cancer (NSCLC) and malignant mesothelioma: therapeutic implications Research Paper

Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2^S310F mutated extramammary Paget’s disease Research Paper