The Oncosearch | Oncotarget

Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers Research Paper

Ai-Sheng Ho, Chien-Hsin Chen, Chun-Chia Cheng, Chia-Chi Wang, Hua-Ching Lin, Tsai-Yueh Luo, Gi-Shih Lien, Jungshan Chang

Published Jan 14, 2014 · Vol. 5, No. 2 · pp. 473-480

Keywords: biomarker, colorectal cancer, neutrophil elastase

WNT-pathway components as predictive markers useful for diagnosis, prevention and therapy in inflammatory bowel disease and sporadic colorectal cancer Research Paper

Annalucia Serafino, Noemi Moroni, Manuela Zonfrillo, Federica Andreola, Luana Mercuri, Giuseppe Nicotera, Joseph Nunziata, Riccardo Ricci, Armando Antinori, Guido Rasi, Pasquale Pierimarchi

Published Jan 11, 2014 · Vol. 5, No. 4 · pp. 978-992

Keywords: Wnt/Î²-catenin pathway, Colorectal carcinogenesis, Inflammatory Bowel Disease, Diagnostic/therapeutic biomarkers, Multiparametric analysis

Minor grove binding ligands disrupt PARP-1 activation pathways Research Paper

Kirill Kirsanov, Elena Kotova, Petr Makhov, Konstantin Golovine, Ekaterina A. Lesovaya, Vladimir M. Kolenko, Marianna G. Yakubovskaya, Alexei V. Tulin

Published Jan 3, 2014 · Vol. 5, No. 2 · pp. 428-437

Keywords: PARP-1, PARP-1 inhibitors, DNA-binding small molecules, poly(ADP-ribose)

CITED1 confers stemness to Wilms tumor and enhances tumorigenic responses when enriched in the nucleus Research Paper

Andrew J. Murphy, Janene Pierce, Christian de Caestecker, Gregory D. Ayers, Alex Zhao, Jonathan R. Krebs, Vincente Kenyi Saito-Diaz, Ethan Lee, Alan O. Perantoni, Mark P. de Caestecker, Harold N. Lovvorn, III

Published Dec 28, 2013 · Vol. 5, No. 2 · pp. 386-402

Keywords: CITED1, Wilms tumor, WNT, WiT49, cancer stem cell

A TRAF2 binding independent region of TNFR2 is responsible for TRAF2 depletion and enhancement of cytotoxicity driven by TNFR1 Research Paper

LucÃa Cabal-Hierro, Noelia Artime, JuliÃ¡n Iglesias, Miguel A. Prado, Lorea Ugarte-Gil, Pedro Casado, BelÃ©n FernÃ¡ndez-GarcÃa, Bryant G. Darnay, Pedro S. Lazo

Published Nov 29, 2013 · Vol. 5, No. 1 · pp. 224-236

Keywords: TNF receptors, Death Receptors, TRAF2, Apoptosis, NF-kappaB

Targeting nucleocytoplasmic transport in cancer therapy Review

Richard Hill, Bastien Cautain, Nuria de Pedro, Wolfgang Link

Published Nov 24, 2013 · Vol. 5, No. 1 · pp. 11-28

Keywords: Tumor suppressors, Cancer, Anti-cancer therapy, Nuclear export, nuclear import

Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-ÐºB target genes in human breast cancer Research Paper

Alba Dalmases, Irene Gonzalez-Navarrete, Silvia Menendez, Oriol ArpÃ, Josep Maria Coromines, Sonia Servitja, Ignasi Tusquets, Cristina Chamizo, RaÃºl RincÃ³n, LluÃs Espinosa, Anna Bigas, Pilar Eroles, Jessica Furriol, Anna Lluch, Ana Rovira, Joan Albanell, Federico Rojo

Published Nov 23, 2013 · Vol. 5, No. 1 · pp. 196-210

Keywords: breast cancer, chemoresistance, NF-ÐºB, p53, prognosis

NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals Research Paper

Sabine Becker-Weimann, Gaofeng Xiong, Saori Furuta, Ju Han, Irene Kuhn, Uri-David Akavia, Dana Pe'er, Mina J. Bissell, Ren Xu

Published Oct 14, 2013 · Vol. 4, No. 11 · pp. 2010-2020

Keywords: disorganization gene signature, p65, RelB, three-dimensional tissue structure, tissue polarity

Induction of apoptosis by directing oncogenic Bcr-Abl into the nucleus Research Paper

Zheng-Lan Huang, Miao Gao, Qian-Yin Li, Kun Tao, Qing Xiao, Wei-Xi Cao, Wen-Li Feng

Published Oct 9, 2013 · Vol. 4, No. 12 · pp. 2249-2260

Keywords: chronic myeloid leukemia, Bcr-Abl, nuclear localization, rapalog, apoptosis

Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation Research Paper

Jing Liu, Aimin Xu, Karen Siu-Ling Lam, Nai-Sum Wong, Jie Chen, Peter R R Shepherd, Yu Wang

Published Oct 1, 2013 · Vol. 4, No. 10 · pp. 1804-1818

Keywords: Adiponectin, breast cancer, autophagy, cholesterol, LDLR

CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia Research Paper

Andrey Astori, Hanne Kristin Fredly, Thomas Aquinas Aloysius, Lars Bullinger, VÃ©ronique Mansat-De Mas, Pierre de la Grange, Francois Delhommeau, Karen Marie Hagen, Christian RÃ©cher, Isabelle Dusanter-Fourt, Stian Knappskog, Johan Richard Lillehaug, Frederic Pendino, Ã˜ystein Bruserud

Published Aug 15, 2013 · Vol. 4, No. 9 · pp. 1438-1448

Keywords: CXXC5, mRNA, acute myeloid leukemia, chemotherapy, apoptosis

The combination of HDAC and aminopeptidase inhibitors is highly synergistic in myeloma and leads to disruption of the NFÎºB signalling pathway Research Paper

Emma M. Smith, Lei Zhang, Brian A. Walker, Emma L. Davenport, Lauren I. Aronson, David Krige, Leon Hooftman, Alan H. Drummond, Gareth J. Morgan, Faith E. Davies

Published Aug 12, 2013 · Vol. 6, No. 19 · pp. 17314-17327

Keywords: Myeloma, HDAC inhibitor, aminopeptidase inhibitor, NFÎºB

Increased expression and copy number amplification of LINE-1 and SINE B1 retrotransposable elements in murine mammary carcinoma progression Research Paper

Alberto Gualtieri, Federica Andreola, Ilaria Sciamanna, Paola Sinibaldi Vallebona, Annalucia Serafino, Corrado Spadafora

Published Aug 9, 2013 · Vol. 4, No. 11 · pp. 1882-1893

Keywords: LINE-1 retrotransposons, SINE retrotransposons, reverse transcriptase, copy number amplification, breast cancer progression

Understanding the role of NRF2-regulated miRNAs in human malignancies Review

Niraj M Shah, Stuart A Rushworth, Megan Y Murray, Kristian M Bowles, David J MacEwan

Published Aug 8, 2013 · Vol. 4, No. 8 · pp. 1130-1142

Keywords: NRF2, miRNA, transcription factor, oncogenesis, drug resistance

The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes. Research Paper

William J. Fredericks, Jorge Sepulveda, Priti Lal, John E. Tomaszewski, Ming-Fong Lin, Terry McGarvey, Frank J. Rauscher III, S. Bruce Malkowicz

Published Jul 7, 2013 · Vol. 4, No. 7 · pp. 1075-1092

Keywords: TERE1, UBIAD1, prostate cancer, castrate resistant prostate cancer, CRPC, LnCaP, cholesterol, SXR, androgen catabolism, Vitamin K-2

Gli1 Transcriptional Activity is Negatively Regulated by AKT2 in Neuroblastoma Research Paper

Pritha Paul, Natasha S. Volny, Sora Lee, Jingbo Qiao, Dai H. Chung

Published Jun 29, 2013 · Vol. 4, No. 8 · pp. 1149-1157

Keywords: Gli1, AKT2, Neuroblastoma, SUFU

Acetylation of the Cell-Fate Factor Dachshund Determines p53 Binding and Signaling Modules in Breast Cancer Research Paper

Ke Chen, Kongming Wu, Michael Gormley, Adam Ertel, Wei Zhang, Jie Zhou, Gabriele DiSante, Zhiping Li, Hallgeir Rui, Andrew A. Quong, Steven B. McMahon, Haiteng Deng, Michael P. Lisanti, Chenguang Wang, Richard G. Pestell

Published Jun 21, 2013 · Vol. 4, No. 6 · pp. 923-935

Keywords: p53, breast cancer, cell fate, stem cells, dach

Myeloablative Anti-CD20 Radioimmunotherapy +/- High-Dose Chemotherapy Followed by Autologous Stem Cell Support for Relapsed/Refractory B-Cell Lymphoma Results in Excellent Long-Term Survival Research Paper

Julia Y. Wagner, Kathleen Schwarz, Susanne Schreiber, Burkhard Schmidt, Hans-JÃ¼rgen Wester, Markus Schwaiger, Christian Peschel, Christoph von Schilling, Klemens Scheidhauer, Ulrich Keller

Published Jun 12, 2013 · Vol. 4, No. 6 · pp. 899-910

Keywords: Non-Hodgkin lymphoma, CD20, Radioimmunotherapy, High-dose chemotherapy, Autologous stem cell transplantation

Antiestrogen-binding site ligands induce autophagy in myeloma cells that proceeds through alteration of cholesterol metabolism Research Paper

Brigitte Sola, Marc Poirot, Philippe de Medina, Sophie Bustany, VÃ©ronique Marsaud, Sandrine Sivente-Poirot, Jack-Michel Renoir

Published Jun 11, 2013 · Vol. 4, No. 6 · pp. 911-922

Keywords: multiple myeloma, tamoxifen, autophagy, apoptosis, cholesterol metabolism

Musashi1 as a potential therapeutic target and diagnostic marker for lung cancer Research Paper

Xiao-Yang Wang, Huina Yu, R. Ilona Linnpoila, Laodong Li, Dangyu Li, Biwen Bo, Hideyuki Okano, Luis O.F. Penalva, Robert I Glazer

Published May 21, 2013 · Vol. 4, No. 5 · pp. 739-750

Keywords: Musashi1, lung cancer, shRNA, beta-catenin, notch, numb

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Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers Research Paper

WNT-pathway components as predictive markers useful for diagnosis, prevention and therapy in inflammatory bowel disease and sporadic colorectal cancer Research Paper

Minor grove binding ligands disrupt PARP-1 activation pathways Research Paper

CITED1 confers stemness to Wilms tumor and enhances tumorigenic responses when enriched in the nucleus Research Paper

A TRAF2 binding independent region of TNFR2 is responsible for TRAF2 depletion and enhancement of cytotoxicity driven by TNFR1 Research Paper

Targeting nucleocytoplasmic transport in cancer therapy Review

Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-ÐºB target genes in human breast cancer Research Paper

NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals Research Paper

Induction of apoptosis by directing oncogenic Bcr-Abl into the nucleus Research Paper

Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation Research Paper

CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia Research Paper

The combination of HDAC and aminopeptidase inhibitors is highly synergistic in myeloma and leads to disruption of the NFÎºB signalling pathway Research Paper

Increased expression and copy number amplification of LINE-1 and SINE B1 retrotransposable elements in murine mammary carcinoma progression Research Paper

Understanding the role of NRF2-regulated miRNAs in human malignancies Review

The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes. Research Paper

Gli1 Transcriptional Activity is Negatively Regulated by AKT2 in Neuroblastoma Research Paper

Acetylation of the Cell-Fate Factor Dachshund Determines p53 Binding and Signaling Modules in Breast Cancer Research Paper

Myeloablative Anti-CD20 Radioimmunotherapy +/- High-Dose Chemotherapy Followed by Autologous Stem Cell Support for Relapsed/Refractory B-Cell Lymphoma Results in Excellent Long-Term Survival Research Paper

Antiestrogen-binding site ligands induce autophagy in myeloma cells that proceeds through alteration of cholesterol metabolism Research Paper

Musashi1 as a potential therapeutic target and diagnostic marker for lung cancer Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers Research Paper

WNT-pathway components as predictive markers useful for diagnosis, prevention and therapy in inflammatory bowel disease and sporadic colorectal cancer Research Paper

Minor grove binding ligands disrupt PARP-1 activation pathways Research Paper

CITED1 confers stemness to Wilms tumor and enhances tumorigenic responses when enriched in the nucleus Research Paper

A TRAF2 binding independent region of TNFR2 is responsible for TRAF2 depletion and enhancement of cytotoxicity driven by TNFR1 Research Paper

Targeting nucleocytoplasmic transport in cancer therapy Review

Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-ÐºB target genes in human breast cancer Research Paper

NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals Research Paper

Induction of apoptosis by directing oncogenic Bcr-Abl into the nucleus Research Paper

Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation Research Paper

CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia Research Paper

The combination of HDAC and aminopeptidase inhibitors is highly synergistic in myeloma and leads to disruption of the NFÎºB signalling pathway Research Paper

Increased expression and copy number amplification of LINE-1 and SINE B1 retrotransposable elements in murine mammary carcinoma progression Research Paper

Understanding the role of NRF2-regulated miRNAs in human malignancies Review

The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes. Research Paper

Gli1 Transcriptional Activity is Negatively Regulated by AKT2 in Neuroblastoma Research Paper

Acetylation of the Cell-Fate Factor Dachshund Determines p53 Binding and Signaling Modules in Breast Cancer Research Paper

Myeloablative Anti-CD20 Radioimmunotherapy +/- High-Dose Chemotherapy Followed by Autologous Stem Cell Support for Relapsed/Refractory B-Cell Lymphoma Results in Excellent Long-Term Survival Research Paper

Antiestrogen-binding site ligands induce autophagy in myeloma cells that proceeds through alteration of cholesterol metabolism Research Paper

Musashi1 as a potential therapeutic target and diagnostic marker for lung cancer Research Paper