The Oncosearch | Oncotarget

Detection of BRAF splicing variants in plasma-derived cell-free nucleic acids and extracellular vesicles of melanoma patients failing targeted therapy therapies Research Paper

Michael E. Clark, Helen Rizos, Michelle R. Pereira, Ashleigh C. McEvoy, Gabriela Marsavela, Leslie Calapre, Katie Meehan, Olivia Ruhen, Muhammad A. Khattak, Tarek M. Meniawy, Georgina V. Long, Matteo S. Carlino, Alexander M. Menzies, Michael Millward, Melanie Ziman, Elin S. Gray

Published Oct 22, 2020 · Vol. 11, No. 44 · pp. 4016-4027

Keywords: melanoma, targeted therapy, drug resistance, BRAF splicing, extracellular vesicles

MEK inhibitors in non-V600 BRAF mutations and fusions Research Perspective

Douglas B. Johnson, Caroline A. Nebhan, Marcus S. Noel

Published Oct 22, 2020 · Vol. 11, No. 44 · pp. 3900-3903

Keywords: trametinib, MEK, BRAF, atypical, fusion

HIC1 (Hypermethylated in Cancer 1) modulates the contractile activity of prostate stromal fibroblasts and directly regulates CXCL12 expression Research Paper

Marion Dubuissez, Sonia Paget, Souhila Abdelfettah, Nathalie Spruyt, Vanessa Dehennaut, Gaylor Boulay, Ingrid Loison, Clementine de Schutter, Brian R. Rood, Martine Duterque-Coquillaud, Xavier Leroy, Dominique Leprince

Published Oct 21, 2020 · Vol. 11, No. 45 · pp. 4138-4154

Keywords: HIC1, CXCL12, SDF1, α-SMA, Acta2

Biomarkers and novel therapeutic approaches for diffuse large B-cell lymphoma in the era of precision medicine Review

Niraj Lodhi, Moe Tun, Poonam Nagpal, Arati A. Inamdar, Nehad M. Ayoub, Noor Siyam, Lucia Oton-Gonzalez, Angela Gerona, Dainelle Morris, Rana Sandhu, Kwangsun Stephen Suh

Published Oct 20, 2020 · Vol. 11, No. 44 · pp. 4045-4073

Keywords: DLBCL, diagnosis, R-CHOP, precision medicine, prognosis

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

Geraldine O'Sullivan Coyne, Shivaani Kummar, Robert S. Meehan, Khanh Do, Jerry M. Collins, Larry Anderson, Kazusa Ishii, Naoko Takebe, Jennifer Zlott, Lamin Juwara, Richard Piekarz, Howard Streicher, Elad Sharon, Larry Rubinstein, Andrea Regier Voth, Jay Lozier, Angie B. Dull, Deborah Wilsker, Toshinori Hinoue, Peter W. Laird, Katherine V. Ferry-Galow, Robert J. Kinders, Ralph E. Parchment, James H. Doroshow, Alice P. Chen

Published Oct 12, 2020 · Vol. 11, No. 44 · pp. 3959-3971

Keywords: DNA damage repair, base excision repair, MGMT, rational combination therapy, molecular pharmacodynamics

Regulation of breast cancer oncogenesis by the cell of origin’s differentiation state Research Paper

Sarah C. Petrova, Ihsaan Ahmad, Christine Nguyen, Stuart D. Ferrell Jr, Sabrina R. Wilhelm, Yin Ye, Sanford H. Barsky

Published Oct 10, 2020 · Vol. 11, No. 43 · pp. 3832-3848

Keywords: transgenic mice, induced pluripotent stem cells (iPSCs), breast oncogenesis, differentiation

Effect of eflornithine on mutation frequency in temozolomide-treated U87MG cells Research Paper

Noymi Yam, Jason Levin, Zhengzheng Bao, Wubin Qian, Victor A. Levin

Published Oct 9, 2020 · Vol. 11, No. 44 · pp. 3933-3942

Keywords: glioma, eflornithine, temozolomide, chemotherapy, secondary mutations

Polymerized human hemoglobin increases the effectiveness of cisplatin-based chemotherapy in non-small cell lung cancer Research Paper

Alfredo Lucas, Donald A. Belcher, Carlos Munoz, Alexander T. Williams, Andre F. Palmer, Pedro Cabrales

Published Oct 7, 2020 · Vol. 11, No. 42 · pp. 3770-3781

Keywords: chemotherapy, cisplatin, polymerized hemoglobin, non-small cell lung cancer, hypoxia

TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic Priority Research Paper

Marie D. Ralff, Aakash Jhaveri, Jocelyn E. Ray, Lanlan Zhou, Avital Lev, Kerry S. Campbell, David T. Dicker, Eric A. Ross, Wafik S. El-Deiry

Published Oct 6, 2020 · Vol. 11, No. 42 · pp. 3753-3769

Keywords: ONC201, TRAIL, breast cancer, death receptors, apoptosis

Targeting an engineered cytokine with interleukin-2 and interleukin-15 activity to the neovasculature of solid tumors Research Paper

Michael R. Mortensen, Jacqueline Mock, Marco Bertolini, Marco Stringhini, Marco Catalano, Dario Neri

Published Oct 6, 2020 · Vol. 11, No. 44 · pp. 3972-3983

Keywords: immunotherapy, immunocytokines, EDB of fibronectin, antibody-cytokine fusion proteins, engineered cytokine

Laser speckle flowgraphy in juxtapapillary retinal capillary hemangioblastoma: a case report on natural course and therapeutic effect Case Report

Mizuho Mitamura, Satoru Kase, Kiriko Hirooka, Susumu Ishida

Published Oct 6, 2020 · Vol. 11, No. 42 · pp. 3800-3804

Keywords: juxtapapillary retinal capillary hemangioblastoma, laser photocoagulation, laser speckle flowgraphy, fluorescein angiography, von Hippel-Lindau disease

Evaluations of CRC2631 toxicity, tumor colonization, and genetic stability in the TRAMP prostate cancer model Research Paper

Robert A. Kazmierczak, Bakul Dhagat-Mehta, Elke Gulden, Li Lee, Lixin Ma, Clintin P. Davis-Stober, Austen A. Barnett, Chiswili Yves Chabu

Published Oct 4, 2020 · Vol. 11, No. 44 · pp. 3943-3958

Keywords: salmonella, cancer targeting, prostate cancer, immunotherapy, TRAMP

Exploiting the metabolic dependencies of the broad amino acid transporter SLC6A14 Research Paper

Francesca R. Dejure, Joachim Butzer, Ralph K. Lindemann, Balca R. Mardin

Published Sep 18, 2020 · Vol. 11, No. 48 · pp. 4490-4503

Keywords: SLC6A14, metabolic stress, transcriptional regulation, methionine, AMPK

Targeting breast cancer metabolism with a novel inhibitor of mitochondrial ATP synthesis Research Paper

Myoung Sook Kim, Ramkishore Gernapudi, Yessenia Cedeño Cedeño, Brian M. Polster, Ramon Martinez, Paul Shapiro, Santosh Kesari, Elmar Nurmemmedov, Antonino Passaniti

Published Sep 3, 2020 · Vol. 11, No. 43 · pp. 3863-3885

Keywords: mitochondrial ATP synthase, oxygen consumption rate, ATP synthesis, reactive oxygen species,

Quantitative ultrasound radiomics using texture derivatives in prediction of treatment response to neo-adjuvant chemotherapy for locally advanced breast cancer Research Paper

Archya Dasgupta, Stephen Brade, Lakshmanan Sannachi, Karina Quiaoit, Kashuf Fatima, Daniel DiCenzo, Laurentius O. Osapoetra, Murtuza Saifuddin, Maureen Trudeau, Sonal Gandhi, Andrea Eisen, Frances Wright, Nicole Look-Hong, Ali Sadeghi-Naini, William T. Tran, Belinda Curpen, Gregory J. Czarnota

Published Sep 2, 2020 · Vol. 11, No. 42 · pp. 3782-3792

Keywords: radiomics, breast cancer, texture derivatives, quantitative ultrasound, neoadjuvant chemotherapy

Correction: Tumor-associated macrophages promote tumor metastasis via the TGF-β/SOX9 axis in non-small cell lung cancer Correction

Shuai Zhang, Dehai Che, Fang Yang, Chunling Chi, Hongxue Meng, Jing Shen, Li Qi, Fang Liu, Liyan Lv, Yue Li, Qingwei Meng, Junning Liu, Lihua Shang, Yan Yu

Published Sep 1, 2020 · Vol. 11, No. 52 · pp. 4845-4846

KDM5A and PHF2 positively control expression of pro-metastatic genes repressed by EWS/Fli1, and promote growth and metastatic properties in Ewing sarcoma Research Paper

Tyler S. McCann, Janet K. Parrish, Joseph Hsieh, Marybeth Sechler, Lays M. Sobral, Chelsea Self, Kenneth L. Jones, Andrew Goodspeed, James C. Costello, Paul Jedlicka

Published Aug 29, 2020 · Vol. 11, No. 43 · pp. 3818-3831

Keywords: Ewing sarcoma, metastasis, epigenetics, Jumonji-domain histone demethylase

Deconstructing tumor heterogeneity: the stromal perspective Meeting Report

Renee E. Vickman, Douglas V. Faget, Philip Beachy, David Beebe, Neil A. Bhowmick, Edna Cukierman, Wu-Min Deng, James G. Granneman, Jeffrey Hildesheim, Raghu Kalluri, Ken S. Lau, Ernst Lengyel, Joakim Lundeberg, Jorge Moscat, Peter S. Nelson, Kristian Pietras, Katerina Politi, Ellen Puré, Ruth Scherz-Shouval, Mara H. Sherman, David Tuveson, Ashani T. Weeraratna, Richard M. White, Melissa H. Wong, Elisa C. Woodhouse, Ying Zheng, Simon W. Hayward, Sheila A. Stewart

Published Aug 29, 2020 · Vol. 11, No. 40 · pp. 3621-3632

Keywords: tumor microenvironment, stromal heterogeneity, extracellular matrix, cellular plasticity, therapy resistance

Meta-analysis of gene expression profiling reveals novel basal gene signatures in MCF-10A cells transformed with cadmium Meta-Analysis

Katrina Blommel, Carley S. Knudsen, Kyle Wegner, Swojani Shrestha, Sandeep K. Singhal, Aaron A. Mehus, Scott H. Garrett, Sonalika Singhal, Xudong Zhou, Brent Voels, Donald A. Sens, Seema Somji

Published Aug 27, 2020 · Vol. 11, No. 39 · pp. 3601-3617

Keywords: breast cancer, meta-analysis, cadmium, MCF-10A, basal subtype

Novel combination therapy for melanoma induces apoptosis via a gap junction positive feedback mechanism Research Paper

Archis Bagati, Timothy C. Hutcherson, Zethan Koch, Joseph Pechette, Hossein Dianat, Cory Higley, Lisa Chiu, Yesul Song, Jay Shah, Elana Chazen, Andrew Nicolais, Peter Casey, Kyle Thompson, Kevin Burke, Mikhail A. Nikiforov, Jennifer Zirnheld, Shoshanna N. Zucker

Published Aug 27, 2020 · Vol. 11, No. 37 · pp. 3443-3458

Keywords: non-thermal plasma, gap junction, tirapazamine, melanoma, intercellular communication

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Detection of BRAF splicing variants in plasma-derived cell-free nucleic acids and extracellular vesicles of melanoma patients failing targeted therapy therapies Research Paper

MEK inhibitors in non-V600 BRAF mutations and fusions Research Perspective

HIC1 (Hypermethylated in Cancer 1) modulates the contractile activity of prostate stromal fibroblasts and directly regulates CXCL12 expression Research Paper

Biomarkers and novel therapeutic approaches for diffuse large B-cell lymphoma in the era of precision medicine Review

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

Regulation of breast cancer oncogenesis by the cell of origin’s differentiation state Research Paper

Effect of eflornithine on mutation frequency in temozolomide-treated U87MG cells Research Paper

Polymerized human hemoglobin increases the effectiveness of cisplatin-based chemotherapy in non-small cell lung cancer Research Paper

TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic Priority Research Paper

Targeting an engineered cytokine with interleukin-2 and interleukin-15 activity to the neovasculature of solid tumors Research Paper

Laser speckle flowgraphy in juxtapapillary retinal capillary hemangioblastoma: a case report on natural course and therapeutic effect Case Report

Evaluations of CRC2631 toxicity, tumor colonization, and genetic stability in the TRAMP prostate cancer model Research Paper

Exploiting the metabolic dependencies of the broad amino acid transporter SLC6A14 Research Paper

Targeting breast cancer metabolism with a novel inhibitor of mitochondrial ATP synthesis Research Paper

Quantitative ultrasound radiomics using texture derivatives in prediction of treatment response to neo-adjuvant chemotherapy for locally advanced breast cancer Research Paper

Correction: Tumor-associated macrophages promote tumor metastasis via the TGF-β/SOX9 axis in non-small cell lung cancer Correction

KDM5A and PHF2 positively control expression of pro-metastatic genes repressed by EWS/Fli1, and promote growth and metastatic properties in Ewing sarcoma Research Paper

Deconstructing tumor heterogeneity: the stromal perspective Meeting Report

Meta-analysis of gene expression profiling reveals novel basal gene signatures in MCF-10A cells transformed with cadmium Meta-Analysis

Novel combination therapy for melanoma induces apoptosis via a gap junction positive feedback mechanism Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Detection of BRAF splicing variants in plasma-derived cell-free nucleic acids and extracellular vesicles of melanoma patients failing targeted therapy therapies Research Paper

MEK inhibitors in non-V600 BRAF mutations and fusions Research Perspective

HIC1 (Hypermethylated in Cancer 1) modulates the contractile activity of prostate stromal fibroblasts and directly regulates CXCL12 expression Research Paper

Biomarkers and novel therapeutic approaches for diffuse large B-cell lymphoma in the era of precision medicine Review

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

Regulation of breast cancer oncogenesis by the cell of origin’s differentiation state Research Paper

Effect of eflornithine on mutation frequency in temozolomide-treated U87MG cells Research Paper

Polymerized human hemoglobin increases the effectiveness of cisplatin-based chemotherapy in non-small cell lung cancer Research Paper

TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic Priority Research Paper

Targeting an engineered cytokine with interleukin-2 and interleukin-15 activity to the neovasculature of solid tumors Research Paper

Laser speckle flowgraphy in juxtapapillary retinal capillary hemangioblastoma: a case report on natural course and therapeutic effect Case Report

Evaluations of CRC2631 toxicity, tumor colonization, and genetic stability in the TRAMP prostate cancer model Research Paper

Exploiting the metabolic dependencies of the broad amino acid transporter SLC6A14 Research Paper

Targeting breast cancer metabolism with a novel inhibitor of mitochondrial ATP synthesis Research Paper

Quantitative ultrasound radiomics using texture derivatives in prediction of treatment response to neo-adjuvant chemotherapy for locally advanced breast cancer Research Paper

Correction: Tumor-associated macrophages promote tumor metastasis via the TGF-β/SOX9 axis in non-small cell lung cancer Correction

KDM5A and PHF2 positively control expression of pro-metastatic genes repressed by EWS/Fli1, and promote growth and metastatic properties in Ewing sarcoma Research Paper

Deconstructing tumor heterogeneity: the stromal perspective Meeting Report

Meta-analysis of gene expression profiling reveals novel basal gene signatures in MCF-10A cells transformed with cadmium Meta-Analysis

Novel combination therapy for melanoma induces apoptosis via a gap junction positive feedback mechanism Research Paper