The Oncosearch | Oncotarget

High in vitro and in vivo synergistic activity between mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC Research Paper

Elodie Montaudon, Rania El Botty, Sophie Vacher, Olivier Déas, Adnan Naguez, Sophie Chateau-Joubert, Damien Treguer, Ludmilla de Plater, Leïla Zemoura, Fariba Némati, André Nicolas, Alain Chapelier, Alain Livartowski, Stefano Cairo, Catherine Daniel, Marie Brevet, Elisabetta Marangoni, Didier Meseure, Sergio Roman-Roman, Ivan Bieche, Nicolas Girard, Didier Decaudin

Published Mar 26, 2021 · Vol. 12, No. 8 · pp. 859-872

Keywords: NSCLC, Pi3K signalling pathway, mTORC1, RAD001 (everolimus), PLK1

Caloric restriction creates a metabolic pattern of chronological aging delay that in budding yeast differs from the metabolic design established by two other geroprotectors Research Paper

Karamat Mohammad, Vladimir I. Titorenko

Published Mar 19, 2021 · Vol. 12, No. 7 · pp. 608-625

Keywords: cellular aging, geroprotectors, caloric restriction, metabolism, methionine

[¹⁸F]FDG and [¹⁸F]FES positron emission tomography for disease monitoring and assessment of anti-hormonal treatment eligibility in granulosa cell tumors of the ovary Research Paper

Joline F. Roze, Hannah S. van Meurs, Glen R. Monroe, Wouter B. Veldhuis, Luc R.C.W. van Lonkhuijzen, Roel J. Bennink, Jolijn W. Groeneweg, Petronella O. Witteveen, Geertruida N. Jonges, Ronald P. Zweemer, Arthur J.A.T. Braat

Published Mar 19, 2021 · Vol. 12, No. 7 · pp. 665-673

Keywords: positron emission tomography (PET), 18F-fluoroestradiol (¹⁸F-FES), 18F-fluoro-deoxyglucose (¹⁸F-FDG), granulosa cell tumors (GCTs), hormone receptors

Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1 Research Paper

Christelle Morris, Sébastien Durand, Pierre Jalinot

Published Mar 13, 2021 · Vol. 12, No. 7 · pp. 649-664

Keywords: breast cancer, senescence-associated secretory phenotype, eIF3, PARP1, mTORC1

Inhibition of resistant triple-negative breast cancer cells with low-dose 6-mercaptopurine and 5-azacitidine Research Paper

Balraj Singh, Vanessa N. Sarli, Anthony Lucci

Published Mar 12, 2021 · Vol. 12, No. 7 · pp. 626-637

Keywords: resistant TNBC, minimal residual disease, intratumor heterogeneity, breast cancer relapse, metastasis prevention

Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma Research Paper

Charles R. Schutt, Hua Sun, Jaya Sarin Pradhan, Yvonne Saenger, Jessica Ley, Douglas Adkins, Matthew Ingham, Li Ding, Brian A. Van Tine

Published Feb 21, 2021 · Vol. 12, No. 6 · pp. 534-548

Keywords: head and neck squamous cell carcinoma, neoantigens, mutational evolution, tumor relapse, immune cell infiltration

Characterization of the inflammatory microenvironment and hepatic macrophage subsets in experimental hepatocellular carcinoma models Research Paper

Helena Degroote, Sander Lefere, Astrid Vandierendonck, Bart Vanderborght, Tim Meese, Filip Van Nieuwerburgh, Xavier Verhelst, Anja Geerts, Hans Van Vlierberghe, Lindsey Devisscher

Published Feb 20, 2021 · Vol. 12, No. 6 · pp. 562-577

Keywords: hepatocellular carcinoma, macrophage subsets, tumor microenvironment, tumor associated macrophages, inflammation

Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations Research Paper

Asim Joshi, Rohit Mishra, Sanket Desai, Pratik Chandrani, Hitesh Kore, Roma Sunder, Supriya Hait, Prajish Iyer, Vaishakhi Trivedi, Anuradha Choughule, Vanita Noronha, Amit Joshi, Vijay Patil, Nandini Menon, Rajiv Kumar, Kumar Prabhash, Amit Dutt

Published Feb 19, 2021 · Vol. 12, No. 6 · pp. 578-588

Keywords: lung squamous carcinoma, genetic alterations, druggable mutations, whole exome sequencing, mass spectrometry

Pancreatic cancer driver mutations are targetable through distant alternative RNA splicing dependencies Research Perspective

Ryan R. Kawalerski, Steven D. Leach, Luisa F. Escobar-Hoyos

Published Feb 12, 2021 · Vol. 12, No. 6 · pp. 525-533

Keywords: pancreatic cancer, RNA splicing, targeted therapy, KRAS, TP53

Reg4 and its downstream transcriptional activator CD44ICD in stage II and III colorectal cancer Research Paper

Jared A. Sninsky, Kumar S. Bishnupuri, Iván González, Nikolaos A. Trikalinos, Ling Chen, Brian K. Dieckgraefe

Published Feb 8, 2021 · Vol. 12, No. 4 · pp. 278-291

Keywords: Reg4, CD44, CD44ICD, colorectal cancer

Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology Research Paper

Bryony J. Telford, Sanaz Yahyanejad, Thijs de Gunst, Harm C. den Boer, Rogier M. Vos, Marieke Stegink, Marion T.J. van den Bosch, Mir Farshid Alemdehy, Laurens A.H. van Pinxteren, Roel Q.J. Schaapveld, Michel Janicot

Published Feb 7, 2021 · Vol. 12, No. 5 · pp. 422-439

Keywords: miR-193a-3p, microRNA mimic, microRNA delivery in vivo, pleiotropic mechanism of microRNA,

Low concentrations of vorinostat decrease EB1 expression in GBM cells and affect microtubule dynamics, cell survival and migration Research Paper

Thomas Perez, Raphaël Bergès, Hélène Maccario, Sarah Oddoux, Stéphane Honoré

Published Feb 5, 2021 · Vol. 12, No. 4 · pp. 304-315

Keywords: vorinostat, glioblastoma, EB1, microtubule, tubulin

Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry Research Paper

Juan Pablo Cerapio, Agnès Marchio, Luis Cano, Ignacio López, Jean-Jacques Fournié, Béatrice Régnault, Sandro Casavilca-Zambrano, Eloy Ruiz, Anne Dejean, Stéphane Bertani, Pascal Pineau

Published Feb 3, 2021 · Vol. 12, No. 5 · pp. 475-492

Keywords: hepatitis B virus, indigenous people, integrative genomics, liver cancer

Quercetin shortened survival of radio-resistant B-1 cells in vitro and in vivo by restoring miR15a/16 expression Research Paper

Yasmim Alefe Leuzzi Ramos, Olivia Fonseca Souza, Marilia Campos Tavares Novo, Caroline Ferreira Cunha Guimarães, Ana Flavia Popi

Published Jan 29, 2021 · Vol. 12, No. 4 · pp. 355-365

Keywords: B-1 cells, chronic lymphocytic leukemia, quercetin, Wnt, miRNA

MicroRNA-214 enriched exosomes from human cerebral endothelial cells (hCEC) sensitize hepatocellular carcinoma to anti-cancer drugs Research Paper

Louie Semaan, Qingning Zeng, Yong Lu, Yi Zhang, Mehdi Mohamad Zreik, Mohamad Baqer Chamseddine, Michael Chopp, Zheng Gang Zhang, Dilip Moonka

Published Jan 25, 2021 · Vol. 12, No. 3 · pp. 185-198

Keywords: hepatocellular carcinoma (HCC), human cerebral endothelial cells-derived exosomes, microRNA-214, therapeutic efficacy, anti-cancer drug

Krüppel-like factor 4 promotes survival and expansion in acute myeloid leukemia cells Research Paper

Andrew Henry Lewis, Cory Seth Bridges, Viraaj Singh Punia, Abraham Fausto Jornada Cooper, Monica Puppi, H. Daniel Lacorazza

Published Jan 25, 2021 · Vol. 12, No. 4 · pp. 255-267

Keywords: acute myeloid leukemia, KLF4, cancer, gene editing, cell growth

Head to head evaluation of second generation ALK inhibitors brigatinib and alectinib as first-line treatment for ALK+ NSCLC using an in silico systems biology-based approach Research Paper

Enric Carcereny, Alonso Fernández-Nistal, Araceli López, Carmen Montoto, Andrea Naves, Cristina Segú-Vergés, Mireia Coma, Guillem Jorba, Baldomero Oliva, Jose Manuel Mas

Published Jan 22, 2021 · Vol. 12, No. 4 · pp. 316-332

Keywords: ALK inhibitor, brigatinib, alectinib, mathematical model, systems biology

Oncolytic virotherapy with SOCS3 enhances viral replicative potency and oncolysis for gastric cancer Research Paper

Shuichi Matsumura, Mikihito Nakamori, Toshiaki Tsuji, Tomoya Kato, Masaki Nakamura, Toshiyasu Ojima, Hiroshi Fukuhara, Yasushi Ino, Tomoki Todo, Hiroki Yamaue

Published Jan 22, 2021 · Vol. 12, No. 4 · pp. 344-354

Keywords: oncolytic virus, herpes simplex virus, gastric cancer

Folinic acid in colorectal cancer: esquire or fellow knight? Real-world results from a mono institutional, retrospective study Research Paper

Francesco Jacopo Romano, Carmela Barbato, Maria Biglietto, Vincenzo Di Lauro, Dario Arundine, Roberto Fiorentino, Francesca Ambrosio, Maresa Cammarota, Bruno Chiurazzi, Livio Puglia, Sarah Scagliarini, Raffaella Ruocco, Carmen Mocerino, Ivana Cerillo, Maria Fiorella Brangi, Ferdinando Riccardi

Published Jan 19, 2021 · Vol. 12, No. 3 · pp. 221-229

Keywords: colorectal cancer, folinic acid, sodium levofolinate, thymidylate synthase, non oncogene addiction

A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells Research Paper

Yuyuan Dai, Hiroyuki Kyoyama, Yi-Lin Yang, Yucheng Wang, Shu Liu, Yinghao Wang, Jian-Hua Mao, Zhidong Xu, Kazutsugu Uematsu, David M. Jablons, Liang You

Published Jan 15, 2021 · Vol. 12, No. 3 · pp. 173-184

Keywords: Homeodomain Interacting Protein Kinase 2 (HIPK2), non-small cell lung cancer (NSCLC), yes-associated protein (YAP), HIPK2 isoform, 4,5,6,7-tetrabromo-2-(1H-imidazol-2-yl)isoindoline-1,3-dione (TBID)

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High in vitro and in vivo synergistic activity between mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC Research Paper

Caloric restriction creates a metabolic pattern of chronological aging delay that in budding yeast differs from the metabolic design established by two other geroprotectors Research Paper

[¹⁸F]FDG and [¹⁸F]FES positron emission tomography for disease monitoring and assessment of anti-hormonal treatment eligibility in granulosa cell tumors of the ovary Research Paper

Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1 Research Paper

Inhibition of resistant triple-negative breast cancer cells with low-dose 6-mercaptopurine and 5-azacitidine Research Paper

Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma Research Paper

Characterization of the inflammatory microenvironment and hepatic macrophage subsets in experimental hepatocellular carcinoma models Research Paper

Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations Research Paper

Pancreatic cancer driver mutations are targetable through distant alternative RNA splicing dependencies Research Perspective

Reg4 and its downstream transcriptional activator CD44ICD in stage II and III colorectal cancer Research Paper

Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology Research Paper

Low concentrations of vorinostat decrease EB1 expression in GBM cells and affect microtubule dynamics, cell survival and migration Research Paper

Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry Research Paper

Quercetin shortened survival of radio-resistant B-1 cells in vitro and in vivo by restoring miR15a/16 expression Research Paper

MicroRNA-214 enriched exosomes from human cerebral endothelial cells (hCEC) sensitize hepatocellular carcinoma to anti-cancer drugs Research Paper

Krüppel-like factor 4 promotes survival and expansion in acute myeloid leukemia cells Research Paper

Head to head evaluation of second generation ALK inhibitors brigatinib and alectinib as first-line treatment for ALK+ NSCLC using an in silico systems biology-based approach Research Paper

Oncolytic virotherapy with SOCS3 enhances viral replicative potency and oncolysis for gastric cancer Research Paper

Folinic acid in colorectal cancer: esquire or fellow knight? Real-world results from a mono institutional, retrospective study Research Paper

A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

High in vitro and in vivo synergistic activity between mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC Research Paper

Caloric restriction creates a metabolic pattern of chronological aging delay that in budding yeast differs from the metabolic design established by two other geroprotectors Research Paper

[18F]FDG and [18F]FES positron emission tomography for disease monitoring and assessment of anti-hormonal treatment eligibility in granulosa cell tumors of the ovary Research Paper

Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1 Research Paper

Inhibition of resistant triple-negative breast cancer cells with low-dose 6-mercaptopurine and 5-azacitidine Research Paper

Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma Research Paper

Characterization of the inflammatory microenvironment and hepatic macrophage subsets in experimental hepatocellular carcinoma models Research Paper

Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations Research Paper

Pancreatic cancer driver mutations are targetable through distant alternative RNA splicing dependencies Research Perspective

Reg4 and its downstream transcriptional activator CD44ICD in stage II and III colorectal cancer Research Paper

Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology Research Paper

Low concentrations of vorinostat decrease EB1 expression in GBM cells and affect microtubule dynamics, cell survival and migration Research Paper

Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry Research Paper

Quercetin shortened survival of radio-resistant B-1 cells in vitro and in vivo by restoring miR15a/16 expression Research Paper

MicroRNA-214 enriched exosomes from human cerebral endothelial cells (hCEC) sensitize hepatocellular carcinoma to anti-cancer drugs Research Paper

Krüppel-like factor 4 promotes survival and expansion in acute myeloid leukemia cells Research Paper

Head to head evaluation of second generation ALK inhibitors brigatinib and alectinib as first-line treatment for ALK+ NSCLC using an in silico systems biology-based approach Research Paper

Oncolytic virotherapy with SOCS3 enhances viral replicative potency and oncolysis for gastric cancer Research Paper

Folinic acid in colorectal cancer: esquire or fellow knight? Real-world results from a mono institutional, retrospective study Research Paper

A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells Research Paper

[¹⁸F]FDG and [¹⁸F]FES positron emission tomography for disease monitoring and assessment of anti-hormonal treatment eligibility in granulosa cell tumors of the ovary Research Paper