The Oncosearch | Oncotarget

Arsenic-induced sub-lethal stress reprograms human bronchial epithelial cells to CD61Â¯ cancer stem cells Research Paper

Qingshan Chang, Bailing Chen, Chitra Thakur, Yongju Lu, Fei Chen

Published Feb 19, 2014 · Vol. 5, No. 5 · pp. 1290-1303

Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer Research Paper

Shigeru Kawabata, Chun-Te Chiang, Junji Tsurutani, Hideaki Shiga, Matthew L. Arwood, Takefumi Komiya, Joell J. Gills, Regan M. Memmott, Phillip A. Dennis

Published Feb 16, 2014 · Vol. 5, No. 4 · pp. 1062-1070

Keywords: Rapamycin, Pemetrexed, Drug synergy, mTOR, Thymidylate Synthase, Lung Cancer

Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo Research Paper

Anna Goc, Belal Al-Husein Al-Husein, Katerina Katsanevas, Alison Steinbach, Uvette Lou, Harika Sabbineni, David L. DeRemer, Payaningal R. Somanath

Published Feb 15, 2014 · Vol. 5, No. 3 · pp. 775-787

PHLPP2 suppresses the NF-ÎºB pathway by inactivating IKKÎ² kinase Research Paper

Nitin Kumar Agarwal, Xiaoping Zhu, Mihai Gagea, Charles L. White, Gilbert Cote, Maria-Magdalena Georgescu

Published Feb 13, 2014 · Vol. 5, No. 3 · pp. 815-823

TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities Research Paper

Zenobia C. D'Costa, Catherine A. Higgins, Chee Wee Ong, Gareth Irwin, David Boyle, Darragh G. McArt, Karen McCloskey, Niamh E. Buckley, Nyree T. Crawford, Lalitha Thiagarajan, James T. Murray, Richard D. Kennedy, Karl A. Mulligan, Denis P. Harkin, David J.J. Waugh, Chris J. Scott, Manuel Salto-Tellez, Richard Williams, Paul B. Mullan

Published Feb 8, 2014 · Vol. 5, No. 6 · pp. 1609-1620

Keywords: TBX2, CST6, LGMN, breast cancer

Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer Research Paper

Francesco Crea, Akira Watahiki, Luca Quagliata, Hui Xue, Larissa Pikor, Abhijit Parolia, Yuwei Wang, Dong Lin, Wan L. Lam, William L. Farrar, Takao Isogai, Rudolf Morant, Serenella Castori-Eppenberger, Kim N. Chi, Yuzhuo Wang, Cheryl D. Helgason

Published Feb 6, 2014 · Vol. 5, No. 3 · pp. 764-774

Enrichment of circulating melanoma cells (CMCs) using negative selection from patients with metastatic melanoma. Research Paper

Powrnima Joshi, Barbara Jacobs, Adeeb Derakhshan, Lee R. Moore, Paul Elson, Pierre L. Triozzi, Ernest Borden, Maciej Zborowski

Published Feb 3, 2014 · Vol. 5, No. 9 · pp. 2450-2461

Keywords: circulating melanoma cells, CTC, Melan-A, S100B, magnetic separation, negative selection

Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene Research Paper

Erling A. Hoivik, Kanthida Kusonmano, Mari K. Halle, Anna Berg, Elisabeth Wik, Henrica M. J. Werner, Kjell Petersen, Anne M. Oyan, Karl-Henning Kalland, Camilla Krakstad, Jone Trovik, Martin Widschwendter, Helga B. Salvesen

Published Jan 28, 2014 · Vol. 5, No. 4 · pp. 1052-1061

Keywords: CTCFL/BORIS, endometrial cancer, Epi-driver gene, recurrence, metastasis

SCF^Î²-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway Research Paper

Jia Liu, Lixin Wan, Pengda Liu, Hiroyuki Inuzuka, Jiankang Liu, Zhiwei Wang, Wenyi Wei

Published Jan 20, 2014 · Vol. 5, No. 4 · pp. 1026-1037

Keywords: Î²-TRCP, NEDD4, degradation, PTEN, Akt, cancer, phosphorylation, ubiquitination, therapy

Immunogenicity of targeted lentivectors Research Paper

Cleo Goyvaerts, De Groeve Kurt, Sandra Van Lint, Carlo Heirman, Jo A. Van Ginderachter, Patrick De Baetselier, Geert Raes, Kris Thielemans, Karine Breckpot

Published Jan 19, 2014 · Vol. 5, No. 3 · pp. 704-715

Keywords: antitumor immunotherapy, lentiviral vectors, targeting, antigen-presenting cells

Quantitative proteomic analysis reveals potential diagnostic markers and pathways involved in pathogenesis of renal cell carcinoma Research Paper

Nicole M.A. White, Olena Masui, Leroi V. DeSouza, Olga Krakovska, Shereen Metias, Alexander D. Romaschin, R.John Honey, Robert Stewart, Kenneth Pace, Jason Lee, Michael AS. Jewett, Georg A. Bjarnason, K.W.Michael Siu, George M. Yousef

Published Jan 18, 2014 · Vol. 5, No. 2 · pp. 506-518

Keywords: kidney cancer, renal cell, carcinoma, iTRAQ, proteomics, Hsp27, urine markers

Antitumor activity of the c-Myc inhibitor KSI-3716 in gemcitabine-resistant bladder cancer Research Paper

Ho Kyung Seo, Kyung-Ohk Ahn, Nae-Rae Jung, Ji-Sun Shin, Weon Seo Park, Kang-Hyun Lee, Sang-Jin Lee, Kyung-Chae Jeong

Published Jan 16, 2014 · Vol. 5, No. 2 · pp. 326-337

Keywords: Bladder cancer, c-Myc, inhibitor, gemcitabine, gemcitabine resistance

GATA2 as a potential metastasis-driving gene in prostate cancer Research Paper

Yan Ting Chiang, Kendric Wang, Ladan Fazli, Robert Z. Qi, Martin E. Gleave, Colin C. Collins, Peter W. Gout, Yuzhuo Wang

Published Jan 12, 2014 · Vol. 5, No. 2 · pp. 451-461

Keywords: GATA2 gene, prostate cancer, metastasis, focal adhesion, master regulatory gene

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo Research Paper

John T. Heap, Jan Theys, Muhammad Ehsaan, Aleksandra M Kubiak, Ludwig Dubois, Kim Paesmans, Lieve Van Mellaert, Richard Knox, Sarah A. Kuehne, Phillipe Lambin, Nigel P. Minton

Published Jan 12, 2014 · Vol. 5, No. 7 · pp. 1761-1769

Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN Research Paper

Tian-Huei Chu, Hoi-Hung Chan, Hsiao-Mei Kuo, Li-Fen Liu, Tsung-Hui Hu, Cheuk-Kwan Sun, Mei-Lang Kung, Shih-Wei Lin, E-Ming Wang, Yi-Ling Ma, Kwan-Hung Cheng, Kwok-Hung Lai, Zhi-Hong Wen, Ping-I Hsu, Ming-Hong Tai

Published Dec 28, 2013 · Vol. 5, No. 6 · pp. 1475-1490

Keywords: hepatocellular carcinoma, hepatic cancer stem cells, celecoxib, prostaglandin E2, phosphatase and tensin homolog

Rac1b negatively regulates TGF-Î²1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling Research Paper

Hendrik Ungefroren, Susanne Sebens, Klaudia Giehl, Ole Helm, Stephanie Groth, Fred Faendrich, Christoph Roecken, Bence Sipos, Hendrik Lehnert, Frank Gieseler

Published Dec 23, 2013 · Vol. 5, No. 1 · pp. 277-290

Keywords: Rac1b, Rac1, Smad, TGF-beta1, pancreatic ductal adenocarcinoma, cell migration

Perspectives of TGF-Î² inhibition in pancreatic and hepatocellular carcinomas Review

Cindy Neuzillet, Armand de Gramont, AnnemilaÃ¯ Tijeras-Raballand, Louis de Mestier, JÃ©rÃ´me Cros, Sandrine Faivre, Eric Raymond

Published Dec 18, 2013 · Vol. 5, No. 1 · pp. 78-94

Keywords: SMAD, stellate cells, extracellular matrix, EMT, TGF-Î² inhibitors

Capturing the biological impact of CDKN2A and MC1R genes as an early predisposing event in melanoma and non melanoma skin cancer. Research Paper

MarÃa JosÃ© Escamez, Francisco Garcia-Garcia, Gemma Tell-Marti, Angels Fabra, LucÃa MartÃnez-SantamarÃa, Celia Badenas, Paula Aguilera, Marta Pevida, JoaquÃn Dopazo, Marcela del RÃo, Susana Puig

Published Dec 16, 2013 · Vol. 5, No. 6 · pp. 1439-1451

Keywords: Familial Melanoma, CDKN2A, MC1R, gene expression, p16, mutations

Loss of E-cadherin activates EGFR-MEK/ERK signaling, which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer Research Paper

Gab-Yong Bae, So-Jung Choi, Ji-Seon Lee, Jisuk Jo, Jinseon Lee, Jhingook Kim, Hyuk-Jin Cha

Published Nov 29, 2013 · Vol. 4, No. 12 · pp. 2512-2522

Keywords: E-Cadherin, EGFR-MEK/ERK signaling, ZEB1, MMP2, Invasion

The proto-oncogene KRAS is targeted by miR-200c Research Paper

Florian Kopp, Ernst Wagner, Andreas Roidl

Published Nov 24, 2013 · Vol. 5, No. 1 · pp. 185-195

Keywords: breast cancer, lung cancer, miRNA, K-ras, cell cycle, proliferation

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

Arsenic-induced sub-lethal stress reprograms human bronchial epithelial cells to CD61Â¯ cancer stem cells Research Paper

Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer Research Paper

Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo Research Paper

PHLPP2 suppresses the NF-ÎºB pathway by inactivating IKKÎ² kinase Research Paper

TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities Research Paper

Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer Research Paper

Enrichment of circulating melanoma cells (CMCs) using negative selection from patients with metastatic melanoma. Research Paper

Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene Research Paper

SCF^Î²-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway Research Paper

Immunogenicity of targeted lentivectors Research Paper

Quantitative proteomic analysis reveals potential diagnostic markers and pathways involved in pathogenesis of renal cell carcinoma Research Paper

Antitumor activity of the c-Myc inhibitor KSI-3716 in gemcitabine-resistant bladder cancer Research Paper

GATA2 as a potential metastasis-driving gene in prostate cancer Research Paper

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo Research Paper

Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN Research Paper

Rac1b negatively regulates TGF-Î²1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling Research Paper

Perspectives of TGF-Î² inhibition in pancreatic and hepatocellular carcinomas Review

Capturing the biological impact of CDKN2A and MC1R genes as an early predisposing event in melanoma and non melanoma skin cancer. Research Paper

Loss of E-cadherin activates EGFR-MEK/ERK signaling, which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer Research Paper

The proto-oncogene KRAS is targeted by miR-200c Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Arsenic-induced sub-lethal stress reprograms human bronchial epithelial cells to CD61Â¯ cancer stem cells Research Paper

Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer Research Paper

Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo Research Paper

PHLPP2 suppresses the NF-ÎºB pathway by inactivating IKKÎ² kinase Research Paper

TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities Research Paper

Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer Research Paper

Enrichment of circulating melanoma cells (CMCs) using negative selection from patients with metastatic melanoma. Research Paper

Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene Research Paper

SCFÎ²-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway Research Paper

Immunogenicity of targeted lentivectors Research Paper

Quantitative proteomic analysis reveals potential diagnostic markers and pathways involved in pathogenesis of renal cell carcinoma Research Paper

Antitumor activity of the c-Myc inhibitor KSI-3716 in gemcitabine-resistant bladder cancer Research Paper

GATA2 as a potential metastasis-driving gene in prostate cancer Research Paper

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo Research Paper

Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN Research Paper

Rac1b negatively regulates TGF-Î²1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling Research Paper

Perspectives of TGF-Î² inhibition in pancreatic and hepatocellular carcinomas Review

Capturing the biological impact of CDKN2A and MC1R genes as an early predisposing event in melanoma and non melanoma skin cancer. Research Paper

Loss of E-cadherin activates EGFR-MEK/ERK signaling, which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer Research Paper

The proto-oncogene KRAS is targeted by miR-200c Research Paper

SCF^Î²-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway Research Paper