The Oncosearch | Oncotarget

Pharmacologic targeting of the PI3K/mTOR pathway controls release of angioregulators from primary human acute myeloid leukemia cells and their neighboring stromal cells Research Paper

HÃ¥kon Reikvam, Ina Nepstad, Ã˜ystein Bruserud, Kimberley Joanne Hatfield

Published May 11, 2013 · Vol. 4, No. 6 · pp. 830-843

Keywords: mTOR â€“ PI3K â€“ Angiogenesis â€“ Bone marrow microenvironment â€“ Pharmacological intervention

Expression of Cancer/Testis Antigens is Correlated with Improved Survival in Glioblastoma Research Paper

Marcelo R.P. Freitas, Suzana M.F. Malheiros, JoÃ£o N. StÃ¡vale, ThaÃs P. Biassi, Fernando T. ZamunÃ©r, Maria D.F.S. Begnami, Fernado A. Soares, AndrÃ© L. Vettore

Published Apr 15, 2013 · Vol. 4, No. 4 · pp. 636-646

Keywords: Glioblastoma, Cancer/Testis antigens

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene Research Paper

Arnaldur Hall, Kathrine Damm Meyle, Marina Krarup Lange, Martin Klima, May Sanderhoff, Christina Dahl, Cecilie Abildgaard, Katrine Thorup, Seyed Moein Moghimi, Per Bo Jensen, Jiri Bartek, Per Guldberg, Claus Christensen

Published Apr 8, 2013 · Vol. 4, No. 4 · pp. 584-599

Keywords: Oncogene addiction, melanoma, V600EBRAF, the Warburg effect, glycolysis, oxidative phosphorylation

Efemp1 and p27Kip1 modulate responsiveness of pancreatic cancer cells towards a dual PI3K/mTOR inhibitor in preclinical models Research Paper

Diersch Sandra, Patrick Wenzel, Melanie Szameitat, Philipp Eser, Mariel C Paul, Barbara Seidler, Stefan Eser, Marlena Messer, Maximilian Reichert, Philipp Pagel, Irene Esposito, Roland M Schmid, Dieter Saur, GÃ¼nter Schneider

Published Feb 26, 2013 · Vol. 4, No. 2 · pp. 277-288

Keywords: pancreatic cancer, PI3K, Efemp1, p27, Bez235

Ras inhibition enhances autophagy, which partially protects cells from death Research Paper

Eran Schmukler, Efrat Grinboim, Sari Schokoroy, Adva Amir, Eya Wolfson, Yoel Kloog, Ronit Pinkas-Kramarski

Published Jan 19, 2013 · Vol. 4, No. 1 · pp. 142-152

Keywords: autophagy, Ras, transformation, signal transduction

Gene expression-based risk score in diffuse large B-cell lymphoma Research Paper

Caroline Bret, Bernard Klein, JÃ©rÃ´me Moreaux

Published Dec 31, 2012 · Vol. 3, No. 12 · pp. 1700-1710

Keywords: DLBCL, gene expression profile, risk score, prognosis

SOCS1 Mutation Subtypes Predict Divergent Outcomes in Diffuse Large B-Cell Lymphoma (DLBCL) Patients Research Paper

Birgit Schif, Jochen K Lennerz, Christian W Kohler, Markus Kreuz, Stefan Bentink, Ingo Melzner, Olga Ritz, Lorenz TrÃ¼mper, Markus LÃ¶ffler, Rainer Spang, Peter MÃ¶ller

Published Dec 9, 2012 · Vol. 4, No. 1 · pp. 35-47

Keywords: biomarker, SOCS, JAK/STAT, GCB

Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine Research Paper

Kyung H Yi, Jossette Axtmayer, John P Gustin, Anandita Rajpurohit, Josh Lauring

Published Nov 29, 2012 · Vol. 4, No. 1 · pp. 29-34

Keywords: AKT1, mutation, personalized, cancer, therapy

Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors. Research Paper

Robert Callahan, Uma Mudunuri, Sharon Bargo, Ahmed Raafat, David McCurdy, Corinne Boulanger, William Lowther, Robert Stephens, Brian T. Luke, Claudia Stewart, Xiaolin Wu, David Munroe, Gilbert H. Smith

Published Oct 17, 2012 · Vol. 3, No. 11 · pp. 1320-1334

Keywords: mouse mammary tumor virus, premalignant lesions, mammary tumors, genes, human breast carcinomas, metastases

Recurrent targets of aberrant somatic hypermutation in lymphoma Research Paper

Alireza Hadj Khodabakhshi, Ryan D Morin, Anthony P Fejes, Andrew J Mungall, Karen L Mungall, Madison Bolger-Munro, Nathalie A Johnson, Joseph M Connors, Randy D Gascoyne, Marco A Marra, Inanc Birol, Steven JM Jones

Published Oct 12, 2012 · Vol. 3, No. 11 · pp. 1308-1319

Keywords: Aberrant somatic hypermutation, Genome wide study, Diffuse large B-cell lymphoma, Genomic rearrangements.

Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma Research Paper

Kasthuri Kannan, Akiko Inagaki, Joachim Silber, Daniel Gorovets, Jianan Zhang, Edward R. Kastenhuber, Adriana Heguy, John H. Petrini, Timothy A. Chan, Jason T. Huse

Published Oct 11, 2012 · Vol. 3, No. 10 · pp. 1194-1203

Keywords: glioma, astrocytoma, IDH, ATRX, whole-exome sequencing

Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity Review

Gerald J Prud'homme, Yelena Glinka

Published Sep 3, 2012 · Vol. 3, No. 9 · pp. 921-939

Keywords: angiogenesis, cancer stem cell, growth factor, neuropilin, semaphorin, TGF-beta, VEGF

Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma Research Paper

Valentina Bevelacqua, Ylenia Bevelacqua, Saverio Candido, Evangelica Skarmoutsou, Alfredo Amoroso, Claudio Guarneri, Angela Strazzanti, Pietro Gangemi, Maria Clorinda Mazzarino, Fabio D'Amico, James A McCubrey, Massimo Libra, Grazia Malaponte

Published Aug 26, 2012 · Vol. 3, No. 8 · pp. 882-892

Keywords: NECL-5, melanoma, nevus, skin

Meta-analysis of clinical data using human meiotic genes identifies a novel cohort of highly restricted cancer-specific marker genes. Research Paper

Julia Feichtinger, Ibrahim Aldeailej, Rebecca Anderson, Mikhlid Almatrafi, Naif Alsiwiehri, keith Griffiths, Nicholas Stuart, Jane A Wakeman, Lee Larcombe, Ramsay James McFarlane

Published Aug 13, 2012 · Vol. 3, No. 8 · pp. 843-853

Keywords: cancer biomarkers, cancer testes antigens, oncogenes, meiosis, PRDM9, cohesins drug targets

The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes Research Paper

Ruchi Singhal, Eugene S. Kandel

Published Jul 31, 2012 · Vol. 3, No. 7 · pp. 700-708

Keywords: IPA3, PAK1, BRAF, NRAS, KRAS, melanoma, colon cancer, GDC-0879, AZD6244

Targeted therapy for hepatocellular carcinoma: novel agents on the horizon Review

Melchiorre Cervello, James A McCubrey, Antonella Cusimano, Nadia Lampiasi, Antonina Azzolina, Giuseppe Montalto

Published Mar 31, 2012 · Vol. 3, No. 3 · pp. 236-260

Keywords: HCC, signaling pathways, EGF/EGFR, Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR, Wnt/Î²-catenin

Over-expression of Thioredoxin-1 mediates growth, survival, and chemoresistance and is a druggable target in diffuse large B-cell lymphoma Research Paper

Changping Li, Michael A. Thompson, Archito T. Tamayo, Zhuang Zuo, John Lee, Francisco Vega, Richard J. Ford, Lan V. Pham

Published Mar 23, 2012 · Vol. 3, No. 3 · pp. 314-326

Keywords: Trx-1, chemoresistance, DLBCL, cellular redox

Proteomic Signatures of the Desmoplastic Invasion Front Reveal Collagen Type XII as a Marker of Myofibroblastic Differentiation During Colorectal Cancer Metastasis Research Paper

George S. Karagiannis, Constantina Petraki, Ioannis Prassas, Punit Saraon, Natasha Musrap, Apostolos Dimitromanolakis, Eleftherios P. Diamandis

Published Mar 8, 2012 · Vol. 3, No. 3 · pp. 267-285

Keywords: Colorectal cancer, Cancer-associated fibroblasts, Desmoplasia, Proteomics, Secretome, Collagen type XII

Engineering the First Chimeric Antibody in Targeting Intracellular PRL-3 Oncoprotein for Cancer Therapy in Mice Research Paper

Ke Guo, Jing Ping Tang, Jie Li, Cheng Peow Tan, Abdul Qader O. Al-Aidaroos, Cheng William Hong, Leyon Varghese, Zhi Wei Feng, Jung Eun Park, Jian Biao Zhou, Wee Joo Chng, Qi Zeng

Published Feb 27, 2012 · Vol. 3, No. 2 · pp. 158-171

Keywords: cancer therapy with chimeric antibody, animal model, intracellular oncotarget, PRL-3 phosphatase

Tumor suppressive microRNA-1285 regulates novel molecular targets: Aberrant expression and functional significance in renal cell carcinoma Research Paper

Hideo Hidaka, Naohiko Seki, Hirofumi Yoshino, Takeshi Yamasaki, Yasutoshi Yamada, Nijiro Nohata, Miki Fuse, Masayuki Nakagawa, Hideki Enokida

Published Jan 30, 2012 · Vol. 3, No. 1 · pp. 44-57

Keywords: microRNA, expression signature, miR-1285, tumor suppressor, renal cell carcinoma, transglutaminase 2

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Pharmacologic targeting of the PI3K/mTOR pathway controls release of angioregulators from primary human acute myeloid leukemia cells and their neighboring stromal cells Research Paper

Expression of Cancer/Testis Antigens is Correlated with Improved Survival in Glioblastoma Research Paper

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene Research Paper

Efemp1 and p27Kip1 modulate responsiveness of pancreatic cancer cells towards a dual PI3K/mTOR inhibitor in preclinical models Research Paper

Ras inhibition enhances autophagy, which partially protects cells from death Research Paper

Gene expression-based risk score in diffuse large B-cell lymphoma Research Paper

SOCS1 Mutation Subtypes Predict Divergent Outcomes in Diffuse Large B-Cell Lymphoma (DLBCL) Patients Research Paper

Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine Research Paper

Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors. Research Paper

Recurrent targets of aberrant somatic hypermutation in lymphoma Research Paper

Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma Research Paper

Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity Review

Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma Research Paper

Meta-analysis of clinical data using human meiotic genes identifies a novel cohort of highly restricted cancer-specific marker genes. Research Paper

The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes Research Paper

Targeted therapy for hepatocellular carcinoma: novel agents on the horizon Review

Over-expression of Thioredoxin-1 mediates growth, survival, and chemoresistance and is a druggable target in diffuse large B-cell lymphoma Research Paper

Proteomic Signatures of the Desmoplastic Invasion Front Reveal Collagen Type XII as a Marker of Myofibroblastic Differentiation During Colorectal Cancer Metastasis Research Paper

Engineering the First Chimeric Antibody in Targeting Intracellular PRL-3 Oncoprotein for Cancer Therapy in Mice Research Paper

Tumor suppressive microRNA-1285 regulates novel molecular targets: Aberrant expression and functional significance in renal cell carcinoma Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Pharmacologic targeting of the PI3K/mTOR pathway controls release of angioregulators from primary human acute myeloid leukemia cells and their neighboring stromal cells Research Paper

Expression of Cancer/Testis Antigens is Correlated with Improved Survival in Glioblastoma Research Paper

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene Research Paper

Efemp1 and p27Kip1 modulate responsiveness of pancreatic cancer cells towards a dual PI3K/mTOR inhibitor in preclinical models Research Paper

Ras inhibition enhances autophagy, which partially protects cells from death Research Paper

Gene expression-based risk score in diffuse large B-cell lymphoma Research Paper

SOCS1 Mutation Subtypes Predict Divergent Outcomes in Diffuse Large B-Cell Lymphoma (DLBCL) Patients Research Paper

Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine Research Paper

Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors. Research Paper

Recurrent targets of aberrant somatic hypermutation in lymphoma Research Paper

Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma Research Paper

Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity Review

Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma Research Paper

Meta-analysis of clinical data using human meiotic genes identifies a novel cohort of highly restricted cancer-specific marker genes. Research Paper

The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes Research Paper

Targeted therapy for hepatocellular carcinoma: novel agents on the horizon Review

Over-expression of Thioredoxin-1 mediates growth, survival, and chemoresistance and is a druggable target in diffuse large B-cell lymphoma Research Paper

Proteomic Signatures of the Desmoplastic Invasion Front Reveal Collagen Type XII as a Marker of Myofibroblastic Differentiation During Colorectal Cancer Metastasis Research Paper

Engineering the First Chimeric Antibody in Targeting Intracellular PRL-3 Oncoprotein for Cancer Therapy in Mice Research Paper

Tumor suppressive microRNA-1285 regulates novel molecular targets: Aberrant expression and functional significance in renal cell carcinoma Research Paper