The Oncosearch | Oncotarget

STAT3 induces the expression of GLI1 in chronic lymphocytic leukemia cells Research Paper

Uri Rozovski, David M. Harris, Ping Li, Zhiming Liu, Preetesh Jain, Taghi Manshouri, Ivo Veletic, Alessandra Ferrajoli, Prithviraj Bose, Phillip Thompson, Nitin Jain, Srdan Verstovsek, William Wierda, Michael J. Keating, Zeev Estrov

Published Jan 30, 2021 · Vol. 12, No. 5 · pp. 401-411

Keywords: CLL, STAT3, GLI1, apoptosis, transcription

High mRNA expression of LY6 gene family is associated with overall survival outcome in pancreatic ductal adenocarcinoma Research Paper

Eric Russ, Krithika Bhuvaneshwar, Guisong Wang, Benjamin Jin, Michele M. Gage, Subha Madhavan, Yuriy Gusev, Geeta Upadhyay

Published Jan 26, 2021 · Vol. 12, No. 3 · pp. 145-159

Keywords: LY6 genes, pancreatic cancer, immune cells, survival outcome

Krüppel-like factor 4 promotes survival and expansion in acute myeloid leukemia cells Research Paper

Andrew Henry Lewis, Cory Seth Bridges, Viraaj Singh Punia, Abraham Fausto Jornada Cooper, Monica Puppi, H. Daniel Lacorazza

Published Jan 25, 2021 · Vol. 12, No. 4 · pp. 255-267

Keywords: acute myeloid leukemia, KLF4, cancer, gene editing, cell growth

Head to head evaluation of second generation ALK inhibitors brigatinib and alectinib as first-line treatment for ALK+ NSCLC using an in silico systems biology-based approach Research Paper

Enric Carcereny, Alonso Fernández-Nistal, Araceli López, Carmen Montoto, Andrea Naves, Cristina Segú-Vergés, Mireia Coma, Guillem Jorba, Baldomero Oliva, Jose Manuel Mas

Published Jan 22, 2021 · Vol. 12, No. 4 · pp. 316-332

Keywords: ALK inhibitor, brigatinib, alectinib, mathematical model, systems biology

Unravelling actionable biology using transcriptomic data to integrate mitotic index and Ki-67 in the management of lung neuroendocrine tumors Research Paper

Venkata S.K. Manem, Olga Sazonova, Andréanne Gagné, Michèle Orain, Babak Khoshkrood-Mansoori, Nathalie Gaudreault, Yohan Bossé, Philippe Joubert

Published Jan 22, 2021 · Vol. 12, No. 3 · pp. 209-220

Keywords: mitotic index, Ki-67, transcriptomics, lung neuroendocrine tumors, pathway analysis

A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells Research Paper

Yuyuan Dai, Hiroyuki Kyoyama, Yi-Lin Yang, Yucheng Wang, Shu Liu, Yinghao Wang, Jian-Hua Mao, Zhidong Xu, Kazutsugu Uematsu, David M. Jablons, Liang You

Published Jan 15, 2021 · Vol. 12, No. 3 · pp. 173-184

Keywords: Homeodomain Interacting Protein Kinase 2 (HIPK2), non-small cell lung cancer (NSCLC), yes-associated protein (YAP), HIPK2 isoform, 4,5,6,7-tetrabromo-2-(1H-imidazol-2-yl)isoindoline-1,3-dione (TBID)

Reversing oncogenic transformation with iron chelation Review

Gina Abdelaal, Stephany Veuger

Published Jan 2, 2021 · Vol. 12, No. 2 · pp. 106-124

Keywords: iron chelator, oncogenesis, selective cytotoxicity, hallmarks of cancer, NDRG1

The noradrenergic profile of plasma metanephrine in neuroblastoma patients is reproduced in xenograft mice models and arise from PNMT downregulation Research Paper

Karim Abid, Maja Beck Popovic, Katia Balmas Bourloud, Jacqueline Schoumans, Joana Grand-Guillaume, Eric Grouzmann, Annick Mühlethaler-Mottet

Published Dec 23, 2020 · Vol. 12, No. 1 · pp. 49-60

Keywords: neuroblastoma, metanephrine, patient-derived xenograft, mouse model, Phenylethanolamine N-Methyltransferase

Standardized diagnostic algorithm for spitzoid lesions aids clinical decision-making and management: a case series from a Swiss reference center Case Report

Marie-Luise Hilbers, Regula Brändli, Beda Mühleisen, Sandra N. Freiberger, Joanna Mangana, Reinhard Dummer

Published Dec 18, 2020 · Vol. 12, No. 2 · pp. 125-130

Keywords: spitzoid nevi, melanocytic lesion, dermatopathology, pediatric dermatology, diagnostic algorithm

Reduction of T-Box 15 gene expression in tumor tissue is a prognostic biomarker for patients with hepatocellular carcinoma Research Paper

Yuji Morine, Tohru Utsunomiya, Yu Saito, Shinichiro Yamada, Satoru Imura, Tetsuya Ikemoto, Akihiro Kitagawa, Yuta Kobayashi, Seiichiro Takao, Keisuke Kosai, Koshi Mimori, Yasuhito Tanaka, Mitsuo Shimada

Published Dec 16, 2020 · Vol. 11, No. 52 · pp. 4803-4812

Keywords: genome-wide analysis, methylation, tumor suppressor gene, prognostic biomarker, hepatocellular carcinoma

Terminally sialylated and fucosylated complex N-glycans are involved in the malignant behavior of high-grade glioma Research Paper

Hector A. Cuello, Gretel M. Ferreira, Cynthia A. Gulino, Alejandro Gomez Toledo, Valeria I. Segatori, Mariano R. Gabri

Published Dec 16, 2020 · Vol. 11, No. 52 · pp. 4822-4835

Keywords: glioma, glioblastoma, Lewis glycans, histone acetylation, N-glycans

Differential gene expression in cisplatin-resistant and -sensitive testicular germ cell tumor cell lines Research Paper

Jan Roška, Lenka Wachsmannová, Lenka Hurbanová, Zuzana Šestáková, Thomas Mueller, Dana Jurkovičová, Miroslav Chovanec

Published Dec 5, 2020 · Vol. 11, No. 51 · pp. 4735-4753

Keywords: gene expression array, cisplatin, testicular germ cell tumors, prognostic biomarkers, pluripotency factors

Novel 3-(3, 5-difluoro-4-hydroxyphenyl)-1-(naphthalen-2-yl) prop-2-en-1-one as a potent inhibitor of MAP-kinase in HeLa cell lines and anti-angiogenic activity is mediated by HIF-1α in EAC animal model Research Paper

Dileep Kumar M. Guruswamy, Kyathegowdana Doddi Srivinavasa Balaji, Kattepura Krishnappa Dharmappa, Shankar Jayarama

Published Nov 27, 2020 · Vol. 11, No. 50 · pp. 4661-4676

Keywords: novel chalcone, Bcl2, caspase 3, BAX, receptor tyrosine kinase inhibitor

Immune-stimulatory (TK/Flt3L) gene therapy opens the door to a promising new treatment strategy against brainstem gliomas Research Perspective

Syed M. Faisal, Flor M. Mendez, Fernando Nunez, Maria G. Castro, Pedro R. Lowenstein

Published Nov 27, 2020 · Vol. 11, No. 50 · pp. 4607-4612

Keywords: immunotherapy, gene therapy, thymidine kinase, Flt3L, DIPG

Identification of nuclear export signal in KLLN suggests potential role in proteasomal degradation in cancer cells Research Paper

Madhav Sankunny, Charis Eng

Published Nov 25, 2020 · Vol. 11, No. 50 · pp. 4625-4636

Keywords: KLLN, nuclear export, NES, proteasomal degradation

High-fat diet-fed ovariectomized mice are susceptible to accelerated subcutaneous tumor growth potentially through adipose tissue inflammation, local insulin-like growth factor release, and tumor associated macrophages Research Paper

Jackie Bader, Meredith Carson, Reilly Enos, Kandy Velazquez, Alexander Sougiannis, Udai Singh, William Becker, Mitzi Nagarkatti, Daping Fan, Angela Murphy

Published Nov 24, 2020 · Vol. 11, No. 49 · pp. 4554-4569

Keywords: colorectal cancer, obesity, metabolism, macrophage, inflammation

Chemotherapy sensitivity testing on ovarian cancer cells isolated from malignant ascites Research Paper

Judith E. den Ouden, Guido J.R. Zaman, Jelle Dylus, Antoon M. van Doornmalen, Winfried R. Mulder, Yvonne Grobben, Wilhelmina E. van Riel, Joanne A. de Hullu, Rogier C. Buijsman, Anne M. van Altena

Published Nov 20, 2020 · Vol. 11, No. 49 · pp. 4570-4581

Keywords: ovarian cancer, chemotherapy sensitivity, prediction, ascites, proliferation assays

Selective amplification of hypermethylated DNA from diverse tumor types via MSRE-PCR Research Paper

Karen B. Chapman, Brandon W. Higgs

Published Nov 18, 2020 · Vol. 11, No. 47 · pp. 4387-4400

Keywords: MSRE-PCR, cDMR, DNA methylation biomarkers, epigenetics, cancer

Cytogenetic and molecular landscape and its potential clinical significance in Hispanic CMML patients from Puerto Rico Research Paper

Zeju Jiang, Xinlai Sun, Zhao Wu, Albert Alhatem, Ruifang Zheng, Dongfang Liu, Yaqun Wang, Dibyendu Kumar, Changqing Xia, Bei You, He Wang, Chen Liu, Jie-Gen Jiang

Published Nov 17, 2020 · Vol. 11, No. 47 · pp. 4411-4420

Keywords: chronic myelomonocytic leukemia, Hispanic, cytogenetic abnormality, gene mutation

Predictors of immunotherapy benefit in Merkel cell carcinoma Research Paper

Alec J. Kacew, Harita Dharaneeswaran, Gabriel J. Starrett, Manisha Thakuria, Nicole R. LeBoeuf, Ann W. Silk, James A. DeCaprio, Glenn J. Hanna

Published Nov 17, 2020 · Vol. 11, No. 47 · pp. 4401-4410

Keywords: cancer, genomics, immunotherapy, Merkel cell carcinoma, precision medicine

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

STAT3 induces the expression of GLI1 in chronic lymphocytic leukemia cells Research Paper

High mRNA expression of LY6 gene family is associated with overall survival outcome in pancreatic ductal adenocarcinoma Research Paper

Krüppel-like factor 4 promotes survival and expansion in acute myeloid leukemia cells Research Paper

Head to head evaluation of second generation ALK inhibitors brigatinib and alectinib as first-line treatment for ALK+ NSCLC using an in silico systems biology-based approach Research Paper

Unravelling actionable biology using transcriptomic data to integrate mitotic index and Ki-67 in the management of lung neuroendocrine tumors Research Paper

A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells Research Paper

Reversing oncogenic transformation with iron chelation Review

The noradrenergic profile of plasma metanephrine in neuroblastoma patients is reproduced in xenograft mice models and arise from PNMT downregulation Research Paper

Standardized diagnostic algorithm for spitzoid lesions aids clinical decision-making and management: a case series from a Swiss reference center Case Report

Reduction of T-Box 15 gene expression in tumor tissue is a prognostic biomarker for patients with hepatocellular carcinoma Research Paper

Terminally sialylated and fucosylated complex N-glycans are involved in the malignant behavior of high-grade glioma Research Paper

Differential gene expression in cisplatin-resistant and -sensitive testicular germ cell tumor cell lines Research Paper

Novel 3-(3, 5-difluoro-4-hydroxyphenyl)-1-(naphthalen-2-yl) prop-2-en-1-one as a potent inhibitor of MAP-kinase in HeLa cell lines and anti-angiogenic activity is mediated by HIF-1α in EAC animal model Research Paper

Immune-stimulatory (TK/Flt3L) gene therapy opens the door to a promising new treatment strategy against brainstem gliomas Research Perspective

Identification of nuclear export signal in KLLN suggests potential role in proteasomal degradation in cancer cells Research Paper

High-fat diet-fed ovariectomized mice are susceptible to accelerated subcutaneous tumor growth potentially through adipose tissue inflammation, local insulin-like growth factor release, and tumor associated macrophages Research Paper

Chemotherapy sensitivity testing on ovarian cancer cells isolated from malignant ascites Research Paper

Selective amplification of hypermethylated DNA from diverse tumor types via MSRE-PCR Research Paper

Cytogenetic and molecular landscape and its potential clinical significance in Hispanic CMML patients from Puerto Rico Research Paper

Predictors of immunotherapy benefit in Merkel cell carcinoma Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

STAT3 induces the expression of GLI1 in chronic lymphocytic leukemia cells Research Paper

High mRNA expression of LY6 gene family is associated with overall survival outcome in pancreatic ductal adenocarcinoma Research Paper

Krüppel-like factor 4 promotes survival and expansion in acute myeloid leukemia cells Research Paper

Head to head evaluation of second generation ALK inhibitors brigatinib and alectinib as first-line treatment for ALK+ NSCLC using an in silico systems biology-based approach Research Paper

Unravelling actionable biology using transcriptomic data to integrate mitotic index and Ki-67 in the management of lung neuroendocrine tumors Research Paper

A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells Research Paper

Reversing oncogenic transformation with iron chelation Review

The noradrenergic profile of plasma metanephrine in neuroblastoma patients is reproduced in xenograft mice models and arise from PNMT downregulation Research Paper

Standardized diagnostic algorithm for spitzoid lesions aids clinical decision-making and management: a case series from a Swiss reference center Case Report

Reduction of T-Box 15 gene expression in tumor tissue is a prognostic biomarker for patients with hepatocellular carcinoma Research Paper

Terminally sialylated and fucosylated complex N-glycans are involved in the malignant behavior of high-grade glioma Research Paper

Differential gene expression in cisplatin-resistant and -sensitive testicular germ cell tumor cell lines Research Paper

Novel 3-(3, 5-difluoro-4-hydroxyphenyl)-1-(naphthalen-2-yl) prop-2-en-1-one as a potent inhibitor of MAP-kinase in HeLa cell lines and anti-angiogenic activity is mediated by HIF-1α in EAC animal model Research Paper

Immune-stimulatory (TK/Flt3L) gene therapy opens the door to a promising new treatment strategy against brainstem gliomas Research Perspective

Identification of nuclear export signal in KLLN suggests potential role in proteasomal degradation in cancer cells Research Paper

High-fat diet-fed ovariectomized mice are susceptible to accelerated subcutaneous tumor growth potentially through adipose tissue inflammation, local insulin-like growth factor release, and tumor associated macrophages Research Paper

Chemotherapy sensitivity testing on ovarian cancer cells isolated from malignant ascites Research Paper

Selective amplification of hypermethylated DNA from diverse tumor types via MSRE-PCR Research Paper

Cytogenetic and molecular landscape and its potential clinical significance in Hispanic CMML patients from Puerto Rico Research Paper

Predictors of immunotherapy benefit in Merkel cell carcinoma Research Paper