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Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer Research Paper

Judith E. Unterlass, Arnaud BaslÃ©, Timothy J. Blackburn, Julie Tucker, CÃ©line Cano, Martin E.M. Noble, Nicola J. Curtin

Published Aug 22, 2016 · Vol. 9, No. 17 · pp. 13139-13153

Interleukin-6 expression contributes to lapatinib resistance through maintenance of stemness property in HER2-positive breast cancer cells Research Paper

Wei-Chien Huang, Chao-Ming Hung, Ching-Ting Wei, Tsung-Ming Chen, Pei-Hsuan Chien, Hsiao-Lin Pan, Yueh-Ming Lin, Yun-Ju Chen

Published Aug 22, 2016 · Vol. 7, No. 38 · pp. 62352-62363

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct Research Paper

Cory A. Ocasio, Mohan B. Rajasekaran, Sarah Walker, Darren Le Grand, John Spencer, Frances M.G. Pearl, Simon E. Ward, Velibor Savic, Laurence H. Pearl, Helfrid Hochegger, Antony W. Oliver

Published Aug 22, 2016 · Vol. 7, No. 44 · pp. 71182-71197

Developing an anticancer copper(II) pro-drug based on the nature of cancer cell and human serum albumin carrier IIA subdomain: mouse model of breast cancer Research Paper

Yi Gou, Yao Zhang, Jinxu Qi, Shifang Chen, Zuping Zhou, Xiaoyang Wu, Hong Liang, Feng Yang

Published Aug 22, 2016 · Vol. 7, No. 41 · pp. 67004-67019

Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance Research Paper

Sofia Avnet, Silvia Lemma, Margherita Cortini, Paola Pellegrini, Francesca Perut, Nicoletta Zini, Katsuyuki Kusuzaki, Tokuhiro Chano, Giulia Grisendi, Massimo Dominici, Angelo De Milito, Nicola Baldini

Published Aug 22, 2016 · Vol. 7, No. 39 · pp. 63408-63423

Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer Research Paper

Jianchang Qian, Yaqing Chen, Tao Meng, Lanping Ma, Lanfang Meng, Xin Wang, Ting Yu, Arie Zask, Jingkang Shen, Ker Yu

Published Aug 22, 2016 · Vol. 7, No. 41 · pp. 67071-67086

Bazedoxifene enhances the anti-tumor effects of cisplatin and radiation treatment by blocking IL-6 signaling in head and neck cancer Research Paper

Arti Yadav, Bhavna Kumar, Theodoros N. Teknos, Pawan Kumar

Published Aug 22, 2016 · Vol. 8, No. 40 · pp. 66912-66924

MicroRNA-34a regulates doxorubicin-induced cardiotoxicity in rat Research Paper

Elena Piegari, Rosa Russo, Donato Cappetta, Grazia Esposito, Konrad Urbanek, Carmela Dellâ€™Aversana, Lucia Altucci, Liberato Berrino, Francesco Rossi, Antonella De Angelis

Published Aug 22, 2016 · Vol. 7, No. 38 · pp. 62312-62326

Tetraspanin CD81 is an adverse prognostic marker in acute myeloid leukemia Research Paper

Thomas Boyer, Soizic Guihard, Christophe Roumier, Pauline Peyrouze, Fanny Gonzales, CÃ©line Berthon, Bruno Quesnel, Claude Preudhomme, HÃ©lÃ¨ne Behal, Alain Duhamel, Catherine Roche-Lestienne, Meyling Cheok

Published Aug 22, 2016 · Vol. 7, No. 38 · pp. 62377-62385

Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways Research Paper

Pamela Ovadje, Saleem Ammar, Jose-Antonio Guerrero, John Thor Arnason, Siyaram Pandey

Published Aug 22, 2016 · Vol. 7, No. 45 · pp. 73080-73100

Candidate germline polymorphisms of genes belonging to the pathways of four drugs used in osteosarcoma standard chemotherapy associated with risk, survival and toxicity in non-metastatic high-grade osteosarcoma Research Paper

Claudia M. Hattinger, Paola Biason, Erika Iacoboni, Sara Gagno, MarilÃ¹ Fanelli, Elisa Tavanti, Serena Vella, Stefano Ferrari, Andrea Roli, Rossana Roncato, Luciana Giodini, Katia Scotlandi, Piero Picci, Giuseppe Toffoli, Massimo Serra

Published Aug 22, 2016 · Vol. 7, No. 38 · pp. 61970-61987

Pediatric Hodgkin lymphomaâ€“ biomarkers, drugs, and clinical trials for translational science and medicine Review

Poonam Nagpal, Mohamed R. Akl, Nehad M. Ayoub, Tatsunari Tomiyama, Tasheka Cousins, Betty Tai, Nicole Carroll, Themba Nyrenda, Pritish Bhattacharyya, Michael B. Harris, Andre Goy, Andrew Pecora, K. Stephen Suh

Published Aug 22, 2016 · Vol. 7, No. 41 · pp. 67551-67573

Synergistic effect of reduced polypeptide micelle for co-delivery of doxorubicin and TRAIL against drug-resistance in breast cancer Research Paper

Chuling Hu, Fenfen Gu, Zongguang Tai, Chong Yao, Chunai Gong, Qingming Xia, Yuan Gao, Shen Gao

Published Aug 20, 2016 · Vol. 7, No. 38 · pp. 61832-61844

Dual targeting of HER3 and MEK may overcome HER3-dependent drug-resistance of colon cancers Research Paper

Giulia Bon, Rossella Loria, Carla Azzurra Amoreo, Alessandra Verdina, Isabella Sperduti, Arianna Mastrofrancesco, Silvia Soddu, Maria Grazia Diodoro, Marcella Mottolese, Matilde Todaro, Giorgio Stassi, Michele Milella, Ruggero De Maria, Rita Falcioni

Published Aug 19, 2016 · Vol. 8, No. 65 · pp. 108463-108479

SH003 suppresses breast cancer growth by accumulating p62 in autolysosomes Research Paper

Youn Kyung Choi, Sung-Gook Cho, Yu-Jeong Choi, Yee Jin Yun, Kang Min Lee, Kangwook Lee, Hye-Hyun Yoo, Yong Cheol Shin, Seong-Gyu Ko

Published Aug 19, 2016 · Vol. 8, No. 51 · pp. 88386-88400

The requirement of SEPT2 and SEPT7 for migration and invasion in human breast cancer via MEK/ERK activation Research Paper

Nianzhu Zhang, Lu Liu, Ning Fan, Qian Zhang, Weijie Wang, Mingnan Zheng, Lingfei Ma, Yan Li, Lei Shi

Published Aug 19, 2016 · Vol. 7, No. 38 · pp. 61587-61600

Gemcitabine enhances cell invasion via activating HAb18G/CD147-EGFR-pSTAT3 signaling Research Paper

Bao-Qing Xu, Zhi-Guang Fu, Yao Meng, Xiao-Qing Wu, Bo Wu, Liang Xu, Jian-Li Jiang, Ling Li, Zhi-Nan Chen

Published Aug 19, 2016 · Vol. 7, No. 38 · pp. 62177-62193

Identification of breast cancer cell subtypes sensitive to ATG4B inhibition Research Paper

Svetlana Bortnik, Courtney Choutka, Hugo M. Horlings, Samuel Leung, Jennifer H.E. Baker, Chandra Lebovitz, Wieslawa H. Dragowska, Nancy E. Go, Marcel B. Bally, Andrew I. Minchinton, Karen A. Gelmon, Sharon M. Gorski

Published Aug 19, 2016 · Vol. 7, No. 41 · pp. 66970-66988

CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia Research Paper

Borja Guerra, Patricia MartÃn-RodrÃguez, Juan Carlos DÃaz-Chico, Grant McNaughton-Smith, Sandra JimÃ©nez-Alonso, Idaira Hueso-FalcÃ³n, Juan Carlos Montero, Rosa Blanco, Javier LeÃ³n, GermÃ¡n RodrÃguez-GonzÃ¡lez, Ana EstÃ©vez-Braun, Atanasio Pandiella, Bonifacio NicolÃ¡s DÃaz-Chico, Leandro FernÃ¡ndez-PÃ©rez

Published Aug 19, 2016 · Vol. 8, No. 18 · pp. 29679-29698

The cytokine-cosmc signaling axis upregulates the tumor-associated carbohydrate antigen Tn Research Paper

Chia-Wen Ho, Chi-Yu Lin, Yi-Wei Liaw, Hsiao-Ling Chiang, Yu-Tang Chin, Rui-Lan Huang, Hung-Cheng Lai, Yaw-Wen Hsu, Po-Jan Kuo, Chiao-En Chen, Hung-Yun Lin, Jacqueline Whang-Peng, Shin Nieh, Earl Fu, Leroy F. Liu, Jaulang Hwang

Published Aug 17, 2016 · Vol. 7, No. 38 · pp. 61930-61944

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Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer Research Paper

Interleukin-6 expression contributes to lapatinib resistance through maintenance of stemness property in HER2-positive breast cancer cells Research Paper

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct Research Paper

Developing an anticancer copper(II) pro-drug based on the nature of cancer cell and human serum albumin carrier IIA subdomain: mouse model of breast cancer Research Paper

Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance Research Paper

Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer Research Paper

Bazedoxifene enhances the anti-tumor effects of cisplatin and radiation treatment by blocking IL-6 signaling in head and neck cancer Research Paper

MicroRNA-34a regulates doxorubicin-induced cardiotoxicity in rat Research Paper

Tetraspanin CD81 is an adverse prognostic marker in acute myeloid leukemia Research Paper

Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways Research Paper

Candidate germline polymorphisms of genes belonging to the pathways of four drugs used in osteosarcoma standard chemotherapy associated with risk, survival and toxicity in non-metastatic high-grade osteosarcoma Research Paper

Pediatric Hodgkin lymphomaâ€“ biomarkers, drugs, and clinical trials for translational science and medicine Review

Synergistic effect of reduced polypeptide micelle for co-delivery of doxorubicin and TRAIL against drug-resistance in breast cancer Research Paper

Dual targeting of HER3 and MEK may overcome HER3-dependent drug-resistance of colon cancers Research Paper

SH003 suppresses breast cancer growth by accumulating p62 in autolysosomes Research Paper

The requirement of SEPT2 and SEPT7 for migration and invasion in human breast cancer via MEK/ERK activation Research Paper

Gemcitabine enhances cell invasion via activating HAb18G/CD147-EGFR-pSTAT3 signaling Research Paper

Identification of breast cancer cell subtypes sensitive to ATG4B inhibition Research Paper

CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia Research Paper

The cytokine-cosmc signaling axis upregulates the tumor-associated carbohydrate antigen Tn Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer Research Paper

Interleukin-6 expression contributes to lapatinib resistance through maintenance of stemness property in HER2-positive breast cancer cells Research Paper

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct Research Paper

Developing an anticancer copper(II) pro-drug based on the nature of cancer cell and human serum albumin carrier IIA subdomain: mouse model of breast cancer Research Paper

Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance Research Paper

Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer Research Paper

Bazedoxifene enhances the anti-tumor effects of cisplatin and radiation treatment by blocking IL-6 signaling in head and neck cancer Research Paper

MicroRNA-34a regulates doxorubicin-induced cardiotoxicity in rat Research Paper

Tetraspanin CD81 is an adverse prognostic marker in acute myeloid leukemia Research Paper

Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways Research Paper

Candidate germline polymorphisms of genes belonging to the pathways of four drugs used in osteosarcoma standard chemotherapy associated with risk, survival and toxicity in non-metastatic high-grade osteosarcoma Research Paper

Pediatric Hodgkin lymphomaâ€“ biomarkers, drugs, and clinical trials for translational science and medicine Review

Synergistic effect of reduced polypeptide micelle for co-delivery of doxorubicin and TRAIL against drug-resistance in breast cancer Research Paper

Dual targeting of HER3 and MEK may overcome HER3-dependent drug-resistance of colon cancers Research Paper

SH003 suppresses breast cancer growth by accumulating p62 in autolysosomes Research Paper

The requirement of SEPT2 and SEPT7 for migration and invasion in human breast cancer via MEK/ERK activation Research Paper

Gemcitabine enhances cell invasion via activating HAb18G/CD147-EGFR-pSTAT3 signaling Research Paper

Identification of breast cancer cell subtypes sensitive to ATG4B inhibition Research Paper

CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia Research Paper

The cytokine-cosmc signaling axis upregulates the tumor-associated carbohydrate antigen Tn Research Paper