The Oncosearch | Oncotarget

Evidence for functional and regulatory cross-talk between Wnt/β-catenin signalling and Mre11–Rad50–Nbs1 complex in the repair of cisplatin-induced DNA cross-links Research Paper

Sanjeev Pasadi, Kalappa Muniyappa

Published Oct 7, 2020 · Vol. 11, No. 44 · pp. 4028-4044

Keywords: cancer, cisplatin resistance, cisplatin-induced DNA crosslinks, Wnt/β-catenin signalling, Mre11–Rad50–Nbs1 complex

Polymerized human hemoglobin increases the effectiveness of cisplatin-based chemotherapy in non-small cell lung cancer Research Paper

Alfredo Lucas, Donald A. Belcher, Carlos Munoz, Alexander T. Williams, Andre F. Palmer, Pedro Cabrales

Published Oct 7, 2020 · Vol. 11, No. 42 · pp. 3770-3781

Keywords: chemotherapy, cisplatin, polymerized hemoglobin, non-small cell lung cancer, hypoxia

Significance of mesothelin expression in preoperative endoscopic biopsy specimens for colorectal cancer prognosis Research Paper

Takehiro Shiraishi, Eiji Shinto, Masato Yamadera, Ken Nagata, Hitoshi Tsuda, Satsuki Mochizuki, Yoshiki Kajiwara, Koichi Okamoto, Takahiro Einama, Yoji Kishi, Hideki Ueno

Published Oct 6, 2020 · Vol. 11, No. 43 · pp. 3807-3817

Keywords: colorectal cancer, mesothelin, endoscopic biopsy specimen, immunohistochemistry, Pathology

Quantitative ultrasound radiomics using texture derivatives in prediction of treatment response to neo-adjuvant chemotherapy for locally advanced breast cancer Research Paper

Archya Dasgupta, Stephen Brade, Lakshmanan Sannachi, Karina Quiaoit, Kashuf Fatima, Daniel DiCenzo, Laurentius O. Osapoetra, Murtuza Saifuddin, Maureen Trudeau, Sonal Gandhi, Andrea Eisen, Frances Wright, Nicole Look-Hong, Ali Sadeghi-Naini, William T. Tran, Belinda Curpen, Gregory J. Czarnota

Published Sep 2, 2020 · Vol. 11, No. 42 · pp. 3782-3792

Keywords: radiomics, breast cancer, texture derivatives, quantitative ultrasound, neoadjuvant chemotherapy

Targeted lymphodepletion with a CD45-directed antibody radioconjugate as a novel conditioning regimen prior to adoptive cell therapy Research Paper

Wojciech Dawicki, Kevin J.H. Allen, Ravendra Garg, Eileen M. Geoghegan, Mark S. Berger, Dale L. Ludwig, Ekaterina Dadachova

Published Aug 26, 2020 · Vol. 11, No. 39 · pp. 3571-3581

Keywords: anti-CD45 targeted lymphodepletion, radioimmunotherapy, adoptive cell therapy, 131Iodine, 177Lutetium

A comprehensive analysis of clinical trials in pancreatic cancer: what is coming down the pike? Research Paper

Erryk S. Katayama, Jonathan J. Hue, David L. Bajor, Lee M. Ocuin, John B. Ammori, Jeffrey M. Hardacre, Jordan M. Winter

Published Aug 24, 2020 · Vol. 11, No. 38 · pp. 3489-3501

Keywords: pancreatic cancer, pancreatic ductal adenocarcinoma, clinical trial, novel treatment, drug development

Diversifying the platinum-based chemotherapy toolkit for immunogenic cancer cell death Editorial

Abhishek D. Garg, Patrizia Agostinis

Published Aug 13, 2020 · Vol. 11, No. 36 · pp. 3352-3353

Keywords: PT-112, immunogenic cell death (ICD), immune-checkpoint blockers (ICBs), tumour microenvironment, apoptosis

The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling Research Paper

Annamil Alvarez-Trotta, Zhiqiang Wang, Elena Shersher, Bin Li, Jun Long, Ines Lohse, Claes Wahlestedt, Wael El-Rifai, David J. Robbins, Anthony J. Capobianco

Published Jul 28, 2020 · Vol. 11, No. 33 · pp. 3174-3187

Keywords: IBET-151, esophageal adenocarcinoma, GDC-0449 resistance, patient-derived xenografts, Hedgehog/GLI signaling pathway

Preclinical evaluation of the anti-tumor activity of pralatrexate in high-risk neuroblastoma cells Research Paper

Rachael A. Clark, Sora Lee, Jingbo Qiao, Dai H. Chung

Published Jul 23, 2020 · Vol. 11, No. 32 · pp. 3069-3077

Keywords: neuroblastoma, pralatrexate, N-myc, folate metabolism

Losartan improves the therapeutic effect of metronomic cyclophosphamide in triple negative mammary cancer models Research Paper

Leandro E. Mainetti, María José Rico, Cintia Daniela Kaufman, Monica Carolina Grillo, Julian Guercetti, María Virginia Baglioni, Antonela Del Giúdice, Maria Celeste Capitani, Matias Fusini, Viviana Rosa Rozados, O. Graciela Scharovsky

Published Jul 22, 2020 · Vol. 11, No. 32 · pp. 3048-3060

Keywords: mammary cancer, metronomic chemotherapy, drug repurposing, cyclophosphamide, losartan

Obinutuzumab (GA101) vs. rituximab significantly enhances cell death, antibody-dependent cytotoxicity and improves overall survival against CD20+ primary mediastinal B-cell lymphoma (PMBL) in a xenograft NOD-scid IL2Rgnull (NSG) mouse model: a potential targeted agent in the treatment of PMBL Research Paper

Yaya Chu, Aradhana Awasthi, Sanghoon Lee, Dina Edani, Changhong Yin, Jessica Hochberg, Tishi Shah, Tae-Hoon Chung, Janet Ayello, Carmella van de Ven, Christian Klein, Dean Lee, Mitchell S. Cairo

Published Jul 21, 2020 · Vol. 11, No. 32 · pp. 3035-3047

Keywords: Obinutuzumab, rituximab, survival, primary mediastinal large B-cell lymphoma, antibody-dependent cellular cytotoxicity

A multicenter, single-arm, basket design, phase II study of NC-6004 plus gemcitabine in patients with advanced unresectable lung, biliary tract, or bladder cancer Research Paper

Simona Ruxandra Volovat, Tudor-Eliade Ciuleanu, Piotr Koralewski, Juneko E. Grilley Olson, Adina Croitoru, Krassimir Koynov, Stefano Stabile, Giulio Cerea, Atsushi Osada, Iulian Bobe, Constantin Volovat

Published Jul 15, 2020 · Vol. 11, No. 33 · pp. 3105-3117

Keywords: cisplatin, NC-6004, non-small cell lung cancer, biliary tract cancer, bladder cancer

Detection of circulating tumor DNA in patients of operative colorectal and gastric cancers Research Paper

Takeyuki Suzuki, Tetsutaro Suzuki, Yukino Yoshimura, Mitsunori Yahata, Poh Yin Yew, Tetsuya Nakamura, Yusuke Nakamura, Jae-Hyun Park, Ryota Matsuo

Published Jul 15, 2020 · Vol. 11, No. 34 · pp. 3198-3207

Keywords: ctDNA, early detection, liquid biopsy, mutation, recurrence

Paradox breaker BRAF inhibitors have comparable potency and MAPK pathway reactivation to encorafenib in BRAF mutant colorectal cancer Research Paper

Oliver J. Pickles, Aneta Drozd, Louise Tee, Andrew D. Beggs, Gary W. Middleton

Published Jul 13, 2020 · Vol. 11, No. 34 · pp. 3188-3197

Keywords: colorectal cancer, BRAF, paradox breaker, encorafenib, PLX8394

Can Denosumab be used in combination with Doxorubicin in Osteosarcoma? Research Paper

Francesca Punzo, Chiara Tortora, Maura Argenziano, Daniela Di Pinto, Elvira Pota, Martina Di Martino, Alessandra Di Paola, Francesca Rossi

Published Jun 27, 2020 · Vol. 11, No. 28 · pp. 2763-2773

Keywords: osteosarcoma, Denosumab, Doxorubicin, RANK-L, bone mass loss

Biomarker analysis to predict the pathological response to neoadjuvant chemotherapy in locally advanced gastric cancer: An exploratory biomarker study of COMPASS, a randomized phase II trial Research Paper

Takashi Oshima, Takaki Yoshikawa, Yohei Miyagi, Satoshi Morita, Michio Yamamoto, Kazuaki Tanabe, Kazuhiro Nishikawa, Yuichi Ito, Takanori Matsui, Yutaka Kimura, Tomoyuki Yokose, Yukihiko Hiroshima, Toru Aoyama, Tsutomu Hayashi, Takashi Ogata, Haruhiko Cho, Yasushi Rino, Munetaka Masuda, Akira Tsuburaya, Junichi Sakamoto

Published Jun 19, 2020 · Vol. 11, No. 30 · pp. 2906-2918

Keywords: gastric cancer, neoadjuvant chemotherapy, pathological response, predictive biomarkers, personalized therapy

Genomic markers of midostaurin drug sensitivity in FLT3 mutated and FLT3 wild-type acute myeloid leukemia patients Research Paper

Mara W. Rosenberg, Kevin Watanabe-Smith, Jeffrey W. Tyner, Cristina E. Tognon, Brian J. Druker, Uma Borate

Published Jun 17, 2020 · Vol. 11, No. 29 · pp. 2807-2818

Keywords: acute myeloid leukemia, drug sensitivity, midostaurin, drug resistance, FLT3

Preoperative geriatric nutritional risk index is a useful prognostic indicator in elderly patients with gastric cancer Research Paper

Noriyuki Hirahara, Takeshi Matsubara, Yusuke Fujii, Shunsuke Kaji, Ryoji Hyakudomi, Tetsu Yamamoto, Yuki Uchida, Yoshiko Miyazaki, Kazunari Ishitobi, Yasunari Kawabata, Yoshitsugu Tajima

Published May 30, 2020 · Vol. 11, No. 24 · pp. 2345-2356

Keywords: geriatric nutritional risk index, overall survival, cancer-specific survival, gastric cancer, elderly patients

Neuroendocrine carcinoma of uterine cervix findings shown by MRI for staging and survival analysis – Japan multicenter study Research Paper

Kazuhiro Kitajima, Takako Kihara, Yusuke Kawanaka, Aki Kido, Kotaro Yoshida, Yasunari Mizumoto, Akiko Tomiyama, Shigeo Okuda, Masahiro Jinzaki, Fumi Kato, Junko Takahama, Akiko Takahata, Yoshihiko Fukukura, Atsushi Nakamoto, Tetsuya Tsujikawa, Jiro Munechika, Yoshimitstu Ohgiya, Nobuyuki Kawai, Satoshi Goshima, Ayumi Ohya, Yasunari Fujinaga, Takeru Fukunaga, Shinya Fujii, Masahiro Tanabe, Katsuyoshi Ito, Takahiro Tsuboyama, Yuichiro Kanie, Shigeaki Umeoka, Shintaro Ichikawa, Utaroh Motosugi, Sayaka Daido, Ayumu Kido, Tsutomu Tamada, Mitsuru Matsuki, Tsuneo Yamashiro, Koichiro Yamakado

Published May 21, 2020 · Vol. 11, No. 40 · pp. 3675-3686

Keywords: cervical cancer, neuroendocrine carcinoma, small cell carcinoma, large cell carcinoma, MRI

Development and characterization of the novel human osteosarcoma cell line COS-33 with sustained activation of the mTOR pathway Research Paper

Ashley VanCleave, Mykayla Palmer, Fang Fang, Haydee Torres, Tania Rodezno, Qilin Li, Kirby Fuglsby, Claire Evans, Yohannes Afeworki, Alan Ross, Pulivarthi Rao, Patricia Leiferman, Siyuan Zheng, Peter Houghton, Jianning Tao

Published May 18, 2020 · Vol. 11, No. 27 · pp. 2597-2610

Keywords: osteosarcoma, COS-33, mTOR, osteogenic differentiation, TP53

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Evidence for functional and regulatory cross-talk between Wnt/β-catenin signalling and Mre11–Rad50–Nbs1 complex in the repair of cisplatin-induced DNA cross-links Research Paper

Polymerized human hemoglobin increases the effectiveness of cisplatin-based chemotherapy in non-small cell lung cancer Research Paper

Significance of mesothelin expression in preoperative endoscopic biopsy specimens for colorectal cancer prognosis Research Paper

Quantitative ultrasound radiomics using texture derivatives in prediction of treatment response to neo-adjuvant chemotherapy for locally advanced breast cancer Research Paper

Targeted lymphodepletion with a CD45-directed antibody radioconjugate as a novel conditioning regimen prior to adoptive cell therapy Research Paper

A comprehensive analysis of clinical trials in pancreatic cancer: what is coming down the pike? Research Paper

Diversifying the platinum-based chemotherapy toolkit for immunogenic cancer cell death Editorial

The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling Research Paper

Preclinical evaluation of the anti-tumor activity of pralatrexate in high-risk neuroblastoma cells Research Paper

Losartan improves the therapeutic effect of metronomic cyclophosphamide in triple negative mammary cancer models Research Paper

A multicenter, single-arm, basket design, phase II study of NC-6004 plus gemcitabine in patients with advanced unresectable lung, biliary tract, or bladder cancer Research Paper

Detection of circulating tumor DNA in patients of operative colorectal and gastric cancers Research Paper

Paradox breaker BRAF inhibitors have comparable potency and MAPK pathway reactivation to encorafenib in BRAF mutant colorectal cancer Research Paper

Can Denosumab be used in combination with Doxorubicin in Osteosarcoma? Research Paper

Biomarker analysis to predict the pathological response to neoadjuvant chemotherapy in locally advanced gastric cancer: An exploratory biomarker study of COMPASS, a randomized phase II trial Research Paper

Genomic markers of midostaurin drug sensitivity in FLT3 mutated and FLT3 wild-type acute myeloid leukemia patients Research Paper

Preoperative geriatric nutritional risk index is a useful prognostic indicator in elderly patients with gastric cancer Research Paper

Neuroendocrine carcinoma of uterine cervix findings shown by MRI for staging and survival analysis – Japan multicenter study Research Paper

Development and characterization of the novel human osteosarcoma cell line COS-33 with sustained activation of the mTOR pathway Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Evidence for functional and regulatory cross-talk between Wnt/β-catenin signalling and Mre11–Rad50–Nbs1 complex in the repair of cisplatin-induced DNA cross-links Research Paper

Polymerized human hemoglobin increases the effectiveness of cisplatin-based chemotherapy in non-small cell lung cancer Research Paper

Significance of mesothelin expression in preoperative endoscopic biopsy specimens for colorectal cancer prognosis Research Paper

Quantitative ultrasound radiomics using texture derivatives in prediction of treatment response to neo-adjuvant chemotherapy for locally advanced breast cancer Research Paper

Targeted lymphodepletion with a CD45-directed antibody radioconjugate as a novel conditioning regimen prior to adoptive cell therapy Research Paper

A comprehensive analysis of clinical trials in pancreatic cancer: what is coming down the pike? Research Paper

Diversifying the platinum-based chemotherapy toolkit for immunogenic cancer cell death Editorial

The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling Research Paper

Preclinical evaluation of the anti-tumor activity of pralatrexate in high-risk neuroblastoma cells Research Paper

Losartan improves the therapeutic effect of metronomic cyclophosphamide in triple negative mammary cancer models Research Paper

A multicenter, single-arm, basket design, phase II study of NC-6004 plus gemcitabine in patients with advanced unresectable lung, biliary tract, or bladder cancer Research Paper

Detection of circulating tumor DNA in patients of operative colorectal and gastric cancers Research Paper

Paradox breaker BRAF inhibitors have comparable potency and MAPK pathway reactivation to encorafenib in BRAF mutant colorectal cancer Research Paper

Can Denosumab be used in combination with Doxorubicin in Osteosarcoma? Research Paper

Biomarker analysis to predict the pathological response to neoadjuvant chemotherapy in locally advanced gastric cancer: An exploratory biomarker study of COMPASS, a randomized phase II trial Research Paper

Genomic markers of midostaurin drug sensitivity in FLT3 mutated and FLT3 wild-type acute myeloid leukemia patients Research Paper

Preoperative geriatric nutritional risk index is a useful prognostic indicator in elderly patients with gastric cancer Research Paper

Neuroendocrine carcinoma of uterine cervix findings shown by MRI for staging and survival analysis – Japan multicenter study Research Paper

Development and characterization of the novel human osteosarcoma cell line COS-33 with sustained activation of the mTOR pathway Research Paper