The Oncosearch | Oncotarget

Broad-spectrum anti-tumor and anti-metastatic DNA vaccine based on p62-encoding vector Research Paper

Franco Venanzi, Victor Shifrin, Michael Y. Sherman, Vladimir Gabai, Oleg Kisilev, Andrey Komissarov, Mikhail Grudinin, Maria Shartakova, Ekaterina Romanovskaya-Romanko, Yuri Kudryavets, Natalya Bezdenezhnykh, Oleksandra Lykhova, Nadiia Semesyuk, Antonio Concetti, Anatoly Tsyb, Marina Filimonova, Victoria Makarchuk, Raisa Yakubovsky, Andrey Chursov, Vita Shcherbinina, Alexander Shneider

Published Oct 2, 2013 · Vol. 4, No. 10 · pp. 1829-1835

Keywords: cancer immunotherapy, DNA vaccine, autophagy, metastases

The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth Research Paper

Elena Kurenova, Jianqun Liao, Di-Hua He, Darrell Hunt, Michael Yemma, Wiam Bshara, Mukund Seshadri, William G Cance

Published Sep 30, 2013 · Vol. 4, No. 10 · pp. 1632-1646

Keywords: FAK Scaffold Inhibitor, pancreatic cancer, FAK-VEGFR-3 interaction, protein-protein interaction

Immunological targeting of tumor cells undergoing an epithelial-mesenchymal transition via a recombinant brachyury-yeast vaccine Research Paper

Duane H. Hamilton, Mary T. Litzinger, Alessandra Jales, Bruce Huang, Romaine I. Fernando, James W. Hodge, Andressa Ardiani, David Apelian, Jeffrey Schlom, Claudia Palena

Published Sep 26, 2013 · Vol. 4, No. 10 · pp. 1777-1790

Keywords: epithelial-mesenchymal transition, brachyury, T-box transcription factor, cancer vaccine, T-cell immunotherapy

CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations Research Paper

Roxana S Redis, Anieta M Siewerts, Maxime P Look, Oana Tudoran, Cristina Ivan, Riccardo Spizzo, Xinna Zhang, Vanja de Weerd, Masayoshi Shimizu, Hui Ling, Rares Buiga, Victor Pop, Alexandru Irimie, Riccardo Fodde, Isabella Bedrosian, John WM Martens, John A Foekens, Ioana Berindan-Neagoe, George A Calin

Published Sep 18, 2013 · Vol. 4, No. 10 · pp. 1748-1762

Keywords: non coding RNA, CCAT2, breast cancer, prognosis, real-time PCR

Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival Research Paper

Aurelie Poli, Jian Wang, Olivia Domingues, JesÃºs PlanagumÃ, Tao Yan, Kai Ove Skaftnesmo, Cecilie Brekke Rygh, Frits Thorsen, Emmet McCormack, FranÃ§ois Hentges, Paal Henning Pedersen, Jacques Zimmer, Per Ã˜yvind Enger, Martha Chekenya

Published Sep 9, 2013 · Vol. 4, No. 9 · pp. 1527-1546

Keywords: Microglia, NK cells, glioblastoma, immunotherapy, NG2/CSPG4

Lung cancer tumorigenicity and drug resistance are maintained through ALDH^hi CD44^hi tumor initiating cells Research Paper

Jing Liu, Zhijie Xiao, Sunny Kit-Man Wong, Vicky Pui-Chi Tin, Ka-Yan Ho, Junwen Wang, Mai-Har Sham, Maria Pik Wong

Published Aug 30, 2013 · Vol. 4, No. 10 · pp. 1698-1711

Keywords: lung cancer, tumor initiating cell, aldehyde dehydrogenase, CD44, drug resistance

The AKT Inhibitor MK-2206 is Cytotoxic in Hepatocarcinoma Cells Displaying Hyperphosphorylated AKT-1 and Synergizes with Conventional Chemotherapy Research Paper

Carolina Simioni, Alberto M. Martelli, Alice Cani, Rengul Cetin-Atalay, James A. McCubrey, Silvano Capitani, Luca M. Neri

Published Aug 24, 2013 · Vol. 4, No. 9 · pp. 1496-1506

Keywords: Hepatocellular carcinoma, MK-2206, Akt-1, targeted therapy, apoptosis, autophagy

Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype. Research Paper

MickaÃ«l Ohanna, Yann Cheli, Caroline Bonet, Vanessa F Bonazzi, Marylin Allegra, Sandy Giuliano, Karine Bille, Philippe Bahadoran, Damien Giacchero, Jean Philippe Lacour, Glen M Boyle, Nicholas F Hayward, Corine Bertolotto, Robert Ballotti

Published Aug 19, 2013 · Vol. 4, No. 12 · pp. 2212-2224

Keywords: melanoma, senescence, secretome, STAT3

CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia Research Paper

Andrey Astori, Hanne Kristin Fredly, Thomas Aquinas Aloysius, Lars Bullinger, VÃ©ronique Mansat-De Mas, Pierre de la Grange, Francois Delhommeau, Karen Marie Hagen, Christian RÃ©cher, Isabelle Dusanter-Fourt, Stian Knappskog, Johan Richard Lillehaug, Frederic Pendino, Ã˜ystein Bruserud

Published Aug 15, 2013 · Vol. 4, No. 9 · pp. 1438-1448

Keywords: CXXC5, mRNA, acute myeloid leukemia, chemotherapy, apoptosis

Understanding the role of NRF2-regulated miRNAs in human malignancies Review

Niraj M Shah, Stuart A Rushworth, Megan Y Murray, Kristian M Bowles, David J MacEwan

Published Aug 8, 2013 · Vol. 4, No. 8 · pp. 1130-1142

Keywords: NRF2, miRNA, transcription factor, oncogenesis, drug resistance

The predictive value of 53BP1 and BRCA1 mRNA expression in advanced non-small-cell lung cancer patients treated with first-line platinum-based chemotherapy Research Paper

Laura Bonanno, Carlota Costa, Margarita Majem, Jose Javier Sanchez, Ana Gimenez-Capitan, Ignacio Rodriguez, Alain Vergenegre, Bartomeu Massuti, Adolfo Favaretto, Massimo Rugge, Cinta Pallares, Miquel Taron, Rafael Rosell

Published Jul 31, 2013 · Vol. 4, No. 10 · pp. 1572-1581

Keywords: BRCA1, 53BP1, DNA repair, predictive modeling, platinum

PTEN loss represses glioblastoma tumor initiating cell differentiation via inactivation of Lgl1 Research Paper

Alexander Gont, Jennifer E. L. Hanson, Sylvie J. Lavictoire, Doris A. E. Parolin, Manijeh Daneshmand, Ian J. restall, Mathieu Soucie, Garth Nicholas, John Woulfe, Amin Kassam, Vasco F. Da Silva, Ian A. J. Lorimer

Published Jul 21, 2013 · Vol. 4, No. 8 · pp. 1266-1279

Keywords: glioblastoma, glioma, PTEN, atypical PKC, Lgl, tumor initiating cell

A novel Mcl1 variant inhibits apoptosis via increased Bim sequestration Research Paper

Judith Hagenbuchner, Ursula Kiechl-Kohlendorfer, Petra Obexer, Michael J. Ausserlechner

Published Jul 15, 2013 · Vol. 4, No. 8 · pp. 1241-1252

Keywords: BCL2 proteins, TRAIL, Fas-induced apoptosis, Noxa

Myeloablative Anti-CD20 Radioimmunotherapy +/- High-Dose Chemotherapy Followed by Autologous Stem Cell Support for Relapsed/Refractory B-Cell Lymphoma Results in Excellent Long-Term Survival Research Paper

Julia Y. Wagner, Kathleen Schwarz, Susanne Schreiber, Burkhard Schmidt, Hans-JÃ¼rgen Wester, Markus Schwaiger, Christian Peschel, Christoph von Schilling, Klemens Scheidhauer, Ulrich Keller

Published Jun 12, 2013 · Vol. 4, No. 6 · pp. 899-910

Keywords: Non-Hodgkin lymphoma, CD20, Radioimmunotherapy, High-dose chemotherapy, Autologous stem cell transplantation

Potent antitumor activity of oncolytic adenovirus expressing Beclin-1 via induction of autophagic cell death in leukemia Research Paper

Yin Tong, Liangshun You, Hui Liu, Lu Li, Haitao Meng, Qijun Qian, Wenbin Qian

Published Jun 3, 2013 · Vol. 4, No. 6 · pp. 860-874

Keywords: leukemia, oncolytic adenovirus, autophagy, Beclin-1, autophagic cell death, UVRAG

Expression of Cancer/Testis Antigens is Correlated with Improved Survival in Glioblastoma Research Paper

Marcelo R.P. Freitas, Suzana M.F. Malheiros, JoÃ£o N. StÃ¡vale, ThaÃs P. Biassi, Fernando T. ZamunÃ©r, Maria D.F.S. Begnami, Fernado A. Soares, AndrÃ© L. Vettore

Published Apr 15, 2013 · Vol. 4, No. 4 · pp. 636-646

Keywords: Glioblastoma, Cancer/Testis antigens

A conceptually new treatment approach for relapsed glioblastoma: Coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care. Review

Richard E. Kast, John A. Boockvar, Ansgar BrÃ¼ning, Francesco Cappello, Wen-Wei Chang, Boris Cvek, Q Ping Dou, Alfonso Duenas-Gonzalez, Thomas Efferth, Daniele Focosi, Seyed H. Ghaffari, Georg Karpel-Massler, Kirsi Ketola, Alireza Khoshnevisan, Daniel Keizman, Nicolas MagnÃ©, Christine Marosi, Kerrie McDonald, Miguel MuÃ±oz, Nathan David Sassoon, Mohammad H. Pourgholami, Iacopo Sardi, Avishay Sella, Kalkunte S. Srivenugopal, Marco Tuccori, Weiguang Wang, Christian R. Wirtz, Marc-Eric Halatsch

Published Apr 13, 2013 · Vol. 4, No. 4 · pp. 502-530

Keywords: angiotensin, aprepitant, artesunate, auranofin, captopril, cytokines, disulfiram, glioblastoma, ketoconazole, nelfinavir, neurokinin, sertraline, temozolomide

Signaling networks, network pathology and computational chemotherapy Editorial

Kwang-Hyun Cho

Published Feb 27, 2013 · Vol. 4, No. 2 · pp. 178-179

Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1) Research Paper

Kristen M. Reipas, Jennifer H. Law, Nicole Couto, Sumaiya Islam, Yvonne Li, Huifang Li, Artem Cherkasov, Karen Jung, Amarpal S. Cheema, Steven J.M. Jones, John A. Hassell, Sandra E. Dunn

Published Feb 27, 2013 · Vol. 4, No. 2 · pp. 329-345

Keywords: Triple-negative breast cancer, p90 ribosomal S6 kinase, Y-box binding protein-1, tumor-initiating cells, drug repositioning

Preclinical analyses of intravesical chemotherapy for prevention of bladder cancer progression Research Paper

Joan C Delto, Takashi Kobayashi, Mitchell C Benson, James McKiernan, Cory Abate-Shen

Published Feb 25, 2013 · Vol. 4, No. 2 · pp. 269-276

Keywords: Non-muscle invasive bladder cancer, intravesical therapy, genetically engineered mouse models, preclinical studies

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Broad-spectrum anti-tumor and anti-metastatic DNA vaccine based on p62-encoding vector Research Paper

The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth Research Paper

Immunological targeting of tumor cells undergoing an epithelial-mesenchymal transition via a recombinant brachyury-yeast vaccine Research Paper

CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations Research Paper

Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival Research Paper

Lung cancer tumorigenicity and drug resistance are maintained through ALDH^hi CD44^hi tumor initiating cells Research Paper

The AKT Inhibitor MK-2206 is Cytotoxic in Hepatocarcinoma Cells Displaying Hyperphosphorylated AKT-1 and Synergizes with Conventional Chemotherapy Research Paper

Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype. Research Paper

CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia Research Paper

Understanding the role of NRF2-regulated miRNAs in human malignancies Review

The predictive value of 53BP1 and BRCA1 mRNA expression in advanced non-small-cell lung cancer patients treated with first-line platinum-based chemotherapy Research Paper

PTEN loss represses glioblastoma tumor initiating cell differentiation via inactivation of Lgl1 Research Paper

A novel Mcl1 variant inhibits apoptosis via increased Bim sequestration Research Paper

Myeloablative Anti-CD20 Radioimmunotherapy +/- High-Dose Chemotherapy Followed by Autologous Stem Cell Support for Relapsed/Refractory B-Cell Lymphoma Results in Excellent Long-Term Survival Research Paper

Potent antitumor activity of oncolytic adenovirus expressing Beclin-1 via induction of autophagic cell death in leukemia Research Paper

Expression of Cancer/Testis Antigens is Correlated with Improved Survival in Glioblastoma Research Paper

A conceptually new treatment approach for relapsed glioblastoma: Coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care. Review

Signaling networks, network pathology and computational chemotherapy Editorial

Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1) Research Paper

Preclinical analyses of intravesical chemotherapy for prevention of bladder cancer progression Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Broad-spectrum anti-tumor and anti-metastatic DNA vaccine based on p62-encoding vector Research Paper

The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth Research Paper

Immunological targeting of tumor cells undergoing an epithelial-mesenchymal transition via a recombinant brachyury-yeast vaccine Research Paper

CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations Research Paper

Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival Research Paper

Lung cancer tumorigenicity and drug resistance are maintained through ALDHhi CD44hi tumor initiating cells Research Paper

The AKT Inhibitor MK-2206 is Cytotoxic in Hepatocarcinoma Cells Displaying Hyperphosphorylated AKT-1 and Synergizes with Conventional Chemotherapy Research Paper

Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype. Research Paper

CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia Research Paper

Understanding the role of NRF2-regulated miRNAs in human malignancies Review

The predictive value of 53BP1 and BRCA1 mRNA expression in advanced non-small-cell lung cancer patients treated with first-line platinum-based chemotherapy Research Paper

PTEN loss represses glioblastoma tumor initiating cell differentiation via inactivation of Lgl1 Research Paper

A novel Mcl1 variant inhibits apoptosis via increased Bim sequestration Research Paper

Myeloablative Anti-CD20 Radioimmunotherapy +/- High-Dose Chemotherapy Followed by Autologous Stem Cell Support for Relapsed/Refractory B-Cell Lymphoma Results in Excellent Long-Term Survival Research Paper

Potent antitumor activity of oncolytic adenovirus expressing Beclin-1 via induction of autophagic cell death in leukemia Research Paper

Expression of Cancer/Testis Antigens is Correlated with Improved Survival in Glioblastoma Research Paper

A conceptually new treatment approach for relapsed glioblastoma: Coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care. Review

Signaling networks, network pathology and computational chemotherapy Editorial

Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1) Research Paper

Preclinical analyses of intravesical chemotherapy for prevention of bladder cancer progression Research Paper

Lung cancer tumorigenicity and drug resistance are maintained through ALDH^hi CD44^hi tumor initiating cells Research Paper