The Oncosearch | Oncotarget

PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesion Research Paper

Jassy Mary S. Lazarte, Kweku Ofosu-Asante, Syreeta L. Tilghman, Nazarius S. Lamango

Published Jul 22, 2025 · Vol. 16, No. 1 · pp. 621-641

Keywords: PCAIs, ROS, MAPK, PI3K/AKT, LTLT-Ca cells

Dissecting the functional differences and clinical features of R-spondin family members in metastatic prostate cancer Research Paper

Aiden Deacon, Ava Gustafson, Allison Makovec, Ella Boytim, Gabriella von Dohlen, David Moline, Elin Kairies, Sam Kellen, Khalid Ishani, Megan L. Ludwig, Emily John, Alexis Anike, Hai Dang Nguyen, Scott M. Dehm, Justin M. Drake, Emmanuel S. Antonarakis, Justin Hwang

Published Jul 19, 2025 · Vol. 16, No. 1 · pp. 606-620

Keywords: RSPO2, prostate cancer, Wnt signaling, genomics, therapeutics

Comprehensive genomic profiling of over 10,000 advanced solid tumors Research Paper

Jean-Paul De La O, Jess R. Hoag, Angela K. Deem, Min Wang, Arthur Starodynov, Sameer S. Udhane, Janine R. LoBello, Nishitha Therala, David W. Hall, Gargi D. Basu, Frederick L. Baehner

Published Jul 19, 2025 · Vol. 16, No. 1 · pp. 587-603

Keywords: solid tumors, comprehensive genomic profiling, matched therapy, gene fusions, limit of detection

Extracorporeal blood filtration leading to tumor growth arrest and reduced analgesic requirements in Stage IV poorly differentiated pancreatic adenocarcinoma: A case report Case Report

Susanna Ulahannan, Peyton Smith, Jennifer Rios, Lakhmir Chawla

Published Jul 18, 2025 · Vol. 16, No. 1 · pp. 582-586

Keywords: extracorporeal blood filtration, circulating tumor cells, metastatic pancreatic cancer, seraph 100, OncoBind

Statins exhibit anti-tumor potential by modulating Wnt/β-catenin signaling in colorectal cancer Research Paper

Sneha Tripathi, Ekta Gupta, Rutika Naik, Satyajeet Khare, Rafeeq Mir, Siddhesh Kamat, Sanjeev Galande

Published Jul 12, 2025 · Vol. 16, No. 1 · pp. 562-581

Keywords: colorectal cancer, statins, SATB1, Wnt/β-catenin signaling, tumor-suppressive phenotype

microRNAs in soft tissue sarcoma: State of the art and barriers to translation Editorial

Elizaveta K. Titerina, Alessandro La Ferlita, Joal D. Beane

Published Jul 12, 2025 · Vol. 16, No. 1 · pp. 560-561

Keywords: soft tissue sarcoma, liposarcoma, microRNA, small non-coding RNA, cancer biomarkers

A novel anti-human CD25 mAb with preferential reactivity to activated T regulatory cells depletes them from the tumor microenvironment Research Paper

Maja Buszko, Madalyn Jones, Sruthi Chempati, Lyra Morina, Kirstin Ward, Habtom Habte, Michael Dziegielewski, Ethan M. Shevach

Published Jun 30, 2025 · Vol. 16, No. 1 · pp. 545-558

Keywords: T_reg, CD25, TME, mAb, GVHD

Retraction: Up-regulation of microRNA let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl Retraction

Clifford C. Nwaeburu, Natalie Bauer, Zhefu Zhao, Alia Abukiwan, Jury Gladkich, Axel Benner, Ingrid Herr

Published Jun 25, 2025 · Vol. 16, No. 1 · pp. 531-531

Hypoxia induced lipid droplet accumulation promotes resistance to ferroptosis in prostate cancer Research Paper

Shailender S. Chauhan, Andres D. Vizzerra, Hope Liou, Caitlyn E. Flores, Ashley J. Snider, Justin M. Snider, Noel A. Warfel

Published Jun 18, 2025 · Vol. 16, No. 1 · pp. 532-544

Keywords: hypoxia, lipid droplets, ferroptosis, resistance, prostate

Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms Review

Shreya Shyamsunder, Zhixin Lu, Vinita Takiar, Susan E. Waltz

Published Jun 16, 2025 · Vol. 16, No. 1 · pp. 508-530

Keywords: EGFR, RTKs, breast cancer, head and neck cancer, resistance mechanisms

Case Report WIN-MTB-2023001 WIN International Molecular Tumor Board A 62-year-old male with metastatic colorectal cancer with 5 prior lines of treatment Precision Oncology

Alberto Hernando-Calvo, Razelle Kurzrock, Nadia Saoudi Gonzalez, Shai Magidi, Catherine Bresson, Fanny Wunder, Giulia Pretelli, Agatha Martin Casado, Wafik S. El-Deiry

Published Jun 9, 2025 · Vol. 16, No. 1 · pp. 456-466

Keywords: cancer, precision oncology, molecular tumor board, colorectal carcinoma, cancer management

Case Report WIN-MTB-2023001 WIN International Molecular Tumor Board A 62-year-old male with metastatic colorectal cancer with 5 prior lines of treatment Case Report

Alberto Hernando-Calvo, Razelle Kurzrock, Nadia Saoudi Gonzalez, Shai Magidi, Catherine Bresson, Fanny Wunder, Giulia Pretelli, Agatha Martin Casado, Wafik S. El-Deiry

Published Jun 9, 2025

Keywords: cancer, precision oncology, molecular tumor board, colorectal carcinoma, cancer management

Genetic characteristics of blastic plasmacytoid dendritic cell neoplasm: A single institution experience Research Paper

Fei Fei, Milhan Telatar, Vanina Tomasian, Lisa Chang, Olga Danilova, Javier Arias-Stella, Raju Pillai, Lorinda Soma, Parastou Tizro, Pamela S. Becker, Anthony S. Stein, Guido Marcucci, Michelle Afkhami

Published Jun 7, 2025 · Vol. 16, No. 1 · pp. 495-507

Keywords: Blastic plasmacytoid dendritic cell neoplasm (BPDCN), Next-generation sequencing (NGS), CCDC50

Optimizing enfortumab vedotin plus pembrolizumab therapy Review

Elias Antoine Karam, Yaghi César Céline, Gilles Prince, Fouad Attieh, Hampig Raphael Kourie, Joseph Kattan, Elie Nemer

Published Jun 5, 2025 · Vol. 16, No. 1 · pp. 481-494

Keywords: advanced urothelial carcinoma (aUC), enfortumab vedotin, pembrolizumab, treatment strategies

Beyond DNA damage response: Immunomodulatory attributes of CHEK2 in solid tumors Review

Helen Qian, Heba Ali, Vivekanudeep Karri, Justin T. Low, David M. Ashley, Amy B. Heimberger, Lucy A. Godley, Adam M. Sonabend, Crismita Dmello

Published Jun 5, 2025 · Vol. 16, No. 1 · pp. 445-453

Keywords: CHEK2, immune checkpoint inhibitors, immunomodulation

Exceptional responders to immunotherapy in pancreatic cancer: A multi-institutional case series of a rare occurrence Research Paper

Kavin Sugumar, Andrew Alabd, Andre Alabd, Jonathan J. Hue, Josh Lyons, Sherri Fields, Zev Wainberg, Lei Zheng, Brianna Coogle, Anup Kasi, Nicholas Grewal, Hedy L. Kindler, Jason Starr, Ashwin R. Sama, Jordan M. Winter

Published Jun 3, 2025 · Vol. 16, No. 1 · pp. 427-442

Keywords: pancreatic adenocarcinoma, immunotherapy, exceptional responders, microsatellite instability, survival

Applying the unattainable triangle in cardio-oncology care: Balancing cost, quality, and time Review

John Hoverson, Chirag Buch, Juan Ulloa-Rodriguez, Samuel Governor, Stella Pak, Prince Otchere

Published Jun 2, 2025 · Vol. 16, No. 1 · pp. 419-424

Keywords: cardio-oncology, quality improvement, cardiology, oncology

Molecular landscape of HER2-mutated non-small cell lung cancer in Northeastern Brazil: Clinical, histopathological, and genomic insights Research Paper

Cleto Dantas Nogueira, Samuel Frota, Huylmer Lucena Chaves, Juliana Cordeiro de Sousa, Guilherme de Sousa Veloso, Francisco Jonathan dos Santos Araujo, Gabriel Barbosa Silva, Samuel Silva Ferreira, Marclesson Santos Alves, Fabio Nasser, Ezequiel Rangel, Francisco Martins Neto, Iusta Caminha, Ellen Nascimento, Fabio Tavora

Published May 31, 2025 · Vol. 16, No. 1 · pp. 467-479

Keywords: HER2 mutation, NSCLC, lung cancer, targeted therapy, genomic profiling

Retraction: Androgen receptor promotes gastric cancer cell migration and invasion via AKT-phosphorylation dependent upregulation of matrix metalloproteinase 9 Retraction

Bao-gui Zhang, Tao Du, Ming-de Zang, Qing Chang, Zhi-yuan Fan, Jian-fang Li, Bei-qin Yu, Li-ping Su, Chen Li, Chao Yan, Qin-long Gu, Zheng-gang Zhu, Min Yan, Bingya Liu

Published May 29, 2025 · Vol. 16, No. 1 · pp. 410-410

Durable complete response in leptomeningeal disease of EGFR mutated non-small cell lung cancer to amivantamab, an EGFR-MET receptor bispecific antibody, after progressing on osimertinib Research Paper

Jinah Kim, Liam Il-Young Chung, Horyun Choi, Yoonhee Choi, Maria Jose Aguilera Chuchuca, Youjin Oh, Young Kwang Chae

Published May 21, 2025 · Vol. 16, No. 1 · pp. 411-418

Keywords: amivantamab, monotherapy, rare EGFR mutation, NSCLC, leptomeningeal disease

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesion Research Paper

Dissecting the functional differences and clinical features of R-spondin family members in metastatic prostate cancer Research Paper

Comprehensive genomic profiling of over 10,000 advanced solid tumors Research Paper

Extracorporeal blood filtration leading to tumor growth arrest and reduced analgesic requirements in Stage IV poorly differentiated pancreatic adenocarcinoma: A case report Case Report

Statins exhibit anti-tumor potential by modulating Wnt/β-catenin signaling in colorectal cancer Research Paper

microRNAs in soft tissue sarcoma: State of the art and barriers to translation Editorial

A novel anti-human CD25 mAb with preferential reactivity to activated T regulatory cells depletes them from the tumor microenvironment Research Paper

Retraction: Up-regulation of microRNA let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl Retraction

Hypoxia induced lipid droplet accumulation promotes resistance to ferroptosis in prostate cancer Research Paper

Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms Review

Case Report WIN-MTB-2023001 WIN International Molecular Tumor Board A 62-year-old male with metastatic colorectal cancer with 5 prior lines of treatment Precision Oncology

Case Report WIN-MTB-2023001 WIN International Molecular Tumor Board A 62-year-old male with metastatic colorectal cancer with 5 prior lines of treatment Case Report

Genetic characteristics of blastic plasmacytoid dendritic cell neoplasm: A single institution experience Research Paper

Optimizing enfortumab vedotin plus pembrolizumab therapy Review

Beyond DNA damage response: Immunomodulatory attributes of CHEK2 in solid tumors Review

Exceptional responders to immunotherapy in pancreatic cancer: A multi-institutional case series of a rare occurrence Research Paper

Applying the unattainable triangle in cardio-oncology care: Balancing cost, quality, and time Review

Molecular landscape of HER2-mutated non-small cell lung cancer in Northeastern Brazil: Clinical, histopathological, and genomic insights Research Paper

Retraction: Androgen receptor promotes gastric cancer cell migration and invasion via AKT-phosphorylation dependent upregulation of matrix metalloproteinase 9 Retraction

Durable complete response in leptomeningeal disease of EGFR mutated non-small cell lung cancer to amivantamab, an EGFR-MET receptor bispecific antibody, after progressing on osimertinib Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesion Research Paper

Dissecting the functional differences and clinical features of R-spondin family members in metastatic prostate cancer Research Paper

Comprehensive genomic profiling of over 10,000 advanced solid tumors Research Paper

Extracorporeal blood filtration leading to tumor growth arrest and reduced analgesic requirements in Stage IV poorly differentiated pancreatic adenocarcinoma: A case report Case Report

Statins exhibit anti-tumor potential by modulating Wnt/β-catenin signaling in colorectal cancer Research Paper

microRNAs in soft tissue sarcoma: State of the art and barriers to translation Editorial

A novel anti-human CD25 mAb with preferential reactivity to activated T regulatory cells depletes them from the tumor microenvironment Research Paper

Retraction: Up-regulation of microRNA let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl Retraction

Hypoxia induced lipid droplet accumulation promotes resistance to ferroptosis in prostate cancer Research Paper

Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms Review

Case Report WIN-MTB-2023001 WIN International Molecular Tumor Board A 62-year-old male with metastatic colorectal cancer with 5 prior lines of treatment Precision Oncology

Case Report WIN-MTB-2023001 WIN International Molecular Tumor Board A 62-year-old male with metastatic colorectal cancer with 5 prior lines of treatment Case Report

Genetic characteristics of blastic plasmacytoid dendritic cell neoplasm: A single institution experience Research Paper

Optimizing enfortumab vedotin plus pembrolizumab therapy Review

Beyond DNA damage response: Immunomodulatory attributes of CHEK2 in solid tumors Review

Exceptional responders to immunotherapy in pancreatic cancer: A multi-institutional case series of a rare occurrence Research Paper

Applying the unattainable triangle in cardio-oncology care: Balancing cost, quality, and time Review

Molecular landscape of HER2-mutated non-small cell lung cancer in Northeastern Brazil: Clinical, histopathological, and genomic insights Research Paper

Retraction: Androgen receptor promotes gastric cancer cell migration and invasion via AKT-phosphorylation dependent upregulation of matrix metalloproteinase 9 Retraction

Durable complete response in leptomeningeal disease of EGFR mutated non-small cell lung cancer to amivantamab, an EGFR-MET receptor bispecific antibody, after progressing on osimertinib Research Paper