The Oncosearch | Oncotarget

The long non-coding RNA PCA3: an update of its functions and clinical applications as a biomarker in prostate cancer Review

Ana Emília Goulart Lemos, Aline da Rocha Matos, Luciana Bueno Ferreira, Etel Rodrigues Pereira Gimba

Published Nov 12, 2019 · Vol. 10, No. 61 · pp. 6589-6603

Keywords: PCA3, prostate cancer, biomarker, long non-coding RNA (lncRNA), clinical applications

Splicing regulatory factors in breast cancer hallmarks and disease progression Review

Esmee Koedoot, Liesanne Wolters, Bob van de Water, Sylvia E. Le Dévédec

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 6021-6037

Keywords: hallmarks of cancer, breast cancer, alternative splicing, splice factors, RNA sequencing

The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer Research Paper

Shiho Fukui, Kazunori Nagasaka, Yuko Miyagawa, Ryoko Kikuchi-Koike, Yoshiko Kawata, Ranka Kanda, Takayuki Ichinose, Takeru Sugihara, Haruko Hiraike, Osamu Wada-Hiraike, Yuko Sasajima, Takuya Ayabe

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 5932-5948

Keywords: ovarian cancer, bAP15, TGF-β/Smad signaling, UCHL5, apoptosis

Two novel ligand-independent variants of the VEGFR-1 receptor are expressed in human testis and spermatozoa, one of them with the ability to activate SRC proto-oncogene tyrosine kinases Research Paper

Belen Alvarez-Palomo, Carme Barrot-Feixat, Helena Sarret, Jordi Requena, Montserrat Pau, Jose-Manuel Vidal-Taboada, Rafael Oliva, Josep-Lluis Ballesca, Michael J. Edel, Jovita Mezquita-Pla

Published Oct 8, 2019 · Vol. 10, No. 56 · pp. 5871-5887

Keywords: ligand-independent intracellular iVEGFR-1 isoforms, mature testis, spermiogenesis, SRC activation, fertility

Comparison of different semi-automated cfDNA extraction methods in combination with UMI-based targeted sequencing Research Paper

Anna Streubel, Albrecht Stenzinger, Susann Stephan-Falkenau, Jens Kollmeier, Daniel Misch, Torsten Gerriet Blum, Torsten Bauer, Olfert Landt, Alexander Am Ende, Peter Schirmacher, Thomas Mairinger, Volker Endris

Published Oct 1, 2019 · Vol. 10, No. 55 · pp. 5690-5702

Keywords: lung cancer, liquid biopsy, cfDNA, molecular diagnostics, T790M

Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells Research Paper

Piyush More, Ute Goedtel-Armbrust, Viral Shah, Marianne Mathaes, Thomas Kindler, Miguel A. Andrade-Navarro, Leszek Wojnowski

Published Sep 3, 2019 · Vol. 10, No. 51 · pp. 5298-5312

Keywords: topoisomerase II poisons, DNA damage, gene expression, combination therapy, cancer essentiality

Detection of tyrosine kinase inhibitors-induced COX-2 expression in bladder cancer by fluorocoxib A Research Paper

Jennifer Bourn, Sony Pandey, Jashim Uddin, Lawrence Marnett, Maria Cekanova

Published Aug 27, 2019 · Vol. 10, No. 50 · pp. 5168-5180

Keywords: bladder cancer, TKIs, RTKIs, COX-2, targeted therapies

ALK mutation dynamics and clonal evolution in a neuroblastoma model exhibiting two ALK mutations Research Paper

Simon Durand, Cécile Pierre-Eugène, Olivier Mirabeau, Caroline Louis-Brennetot, Valérie Combaret, Léo Colmet-Daage, Orphée Blanchard, Angela Bellini, Estelle Daudigeos-Dubus, Virginie Raynal, Gudrun Schleiermacher, Sylvain Baulande, Olivier Delattre, Isabelle Janoueix-Lerosey

Published Aug 13, 2019 · Vol. 10, No. 48 · pp. 4937-4950

Keywords: neuroblastoma, ALK mutations, heterogeneity, clonal evolution, ALK inhibitors

Oncologist uptake of comprehensive genomic profile guided targeted therapy Research Paper

Mary K. Nesline, Paul DePietro, Grace K. Dy, Amy Early, Antonios Papanicolau-Sengos, Jeffrey M. Conroy, Felicia L. Lenzo, Sean T. Glenn, Hongbin Chen, Anne Grand’Maison, Patrick Boland, Marc S. Ernstoff, Igor Puzanov, Stephen Edge, Stacey Akers, Mateusz Opyrchal, Gurkamal Chatta, Kunle Odunsi, Peter Frederick, Shashikant Lele, Mark Gardner, Carl Morrison

Published Jul 23, 2019 · Vol. 10, No. 45 · pp. 4616-4629

Keywords: comprehensive genomic profiling, targeted therapy, clinical decision making, next-generation sequencing, real world data

Modified Simon’s minimax and optimal two-stage designs for single-arm phase II cancer clinical trials Research Paper

Jongphil Kim, Michael J. Schell

Published Jul 2, 2019 · Vol. 10, No. 42 · pp. 4255-4261

Keywords: admissible two-stage design, binary endpoint, modified two-stage design, Simon’s two-stage design, single-arm phase ii clinical trials

Comparative proteomic analysis of human serum before and after liver transplantation using quantitative proteomics Research Paper

Ruohan Zhang, Minglin Ou, Yue Zhang, Qiang Yan, Huaizhou Chen, Liusheng Lai, Ying Li, Feilong Xu, Donge Tang, Xuyong Sun, Jianhui Dong, Yong Dai, Weiguo Sui

Published Apr 2, 2019 · Vol. 10, No. 26 · pp. 2508-2514

A novel anti-melanoma SRC-family kinase inhibitor Research Paper

Ruth Halaban, Antonella Bacchiocchi, Robert Straub, Jian Cao, Mario Sznol, Deepak Narayan, Ahmed Allam, Michael Krauthammer, Tarek S. Mansour

Published Mar 19, 2019 · Vol. 10, No. 23 · pp. 2237-2251

Keywords: melanoma, SRC-family kinase inhibitors, MAPK, MITF

Application of cell-free DNA for genomic tumor profiling: a feasibility study Research Paper

Lise B. Ahlborn, Kristoffer S. Rohrberg, Migle Gabrielaite, Ida V. Tuxen, Christina W. Yde, Iben Spanggaard, Eric Santoni-Rugiu, Finn C. Nielsen, Ulrik Lassen, Morten Mau-Sorensen, Olga Ã˜strup

Published Feb 15, 2019 · Vol. 10, No. 14 · pp. 1388-1398

Synthetic lethality of a cell-penetrating anti-RAD51 antibody in PTEN-deficient melanoma and glioma cells Priority Research Paper

Audrey Turchick, Yanfeng Liu, Weixi Zhao, Inessa Cohen, Peter M. Glazer

Published Feb 12, 2019 · Vol. 10, No. 13 · pp. 1272-1283

Inhibition of ATM kinase upregulates levels of cell death induced by cannabidiol and γ-irradiation in human glioblastoma cells Research Paper

Vladimir N. Ivanov, Jinhua Wu, Tony J.C. Wang, Tom K. Hei

Published Jan 25, 2019 · Vol. 10, No. 8 · pp. 825-846

ALT cancer cells are specifically sensitive to lysine acetyl transferase inhibition Research Paper

Dalal Bakhos-Douaihy, Chantal Desmaze, Maya Jeitany, Laurent R. Gauthier, Denis Biard, Marie-Pierre Junier, HervÃ© Chneiweiss, FranÃ§ois D. Boussin

Published Jan 22, 2019 · Vol. 10, No. 7 · pp. 773-784

FGFR1β is a driver isoform of FGFR1 alternative splicing in breast cancer cells Research Paper

Ming Zhao, Ming-Lei Zhuo, Xiaofeng Zheng, Xiaoping Su, Funda Meric-Bernstam

Published Jan 1, 2019 · Vol. 10, No. 1 · pp. 30-44

Preclinical characterization of tyrosine kinase inhibitor-based targeted therapies for neuroendocrine thyroid cancer Research Paper

Karine Pozo, Stefan Zahler, Keisuke Ishimatsu, Angela M. Carter, Rahul Telange, Chunfeng Tan, Shuaijun Wang, Roswitha Pfragner, Junya Fujimoto, Elizabeth Gardner Grubbs, Masaya Takahashi, Sarah C. Oltmann, James A. Bibb

Published Dec 28, 2018 · Vol. 9, No. 102 · pp. 37662-37675

KLHL5 knockdown increases cellular sensitivity to anticancer drugs Research Paper

Robert J. Schleifer, Shuchun Li, Wyatt Nechtman, Eric Miller, Shan Bai, Ashok Sharma, Jin-Xiong She

Published Dec 21, 2018 · Vol. 9, No. 100 · pp. 37429-37438

Time to progression to castration-resistant prostate cancer after commencing combined androgen blockade for advanced hormone-sensitive prostate cancer Research Paper

Satoshi Tamada, Taro Iguchi, Minoru Kato, Jumpei Asakawa, Kazuaki Kita, Sayaka Yasuda, Takeshi Yamasaki, Yudai Matsuoka, Kazuyuki Yamaguchi, Kentaro Matsumura, Ishun Go, Tetsuji Ohmachi, Tatsuya Nakatani

Published Dec 11, 2018 · Vol. 9, No. 97 · pp. 36966-36974

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Search Oncotarget

The long non-coding RNA PCA3: an update of its functions and clinical applications as a biomarker in prostate cancer Review

Splicing regulatory factors in breast cancer hallmarks and disease progression Review

The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer Research Paper

Two novel ligand-independent variants of the VEGFR-1 receptor are expressed in human testis and spermatozoa, one of them with the ability to activate SRC proto-oncogene tyrosine kinases Research Paper

Comparison of different semi-automated cfDNA extraction methods in combination with UMI-based targeted sequencing Research Paper

Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells Research Paper

Detection of tyrosine kinase inhibitors-induced COX-2 expression in bladder cancer by fluorocoxib A Research Paper

ALK mutation dynamics and clonal evolution in a neuroblastoma model exhibiting two ALK mutations Research Paper

Oncologist uptake of comprehensive genomic profile guided targeted therapy Research Paper

Modified Simon’s minimax and optimal two-stage designs for single-arm phase II cancer clinical trials Research Paper

Comparative proteomic analysis of human serum before and after liver transplantation using quantitative proteomics Research Paper

A novel anti-melanoma SRC-family kinase inhibitor Research Paper

Application of cell-free DNA for genomic tumor profiling: a feasibility study Research Paper

Synthetic lethality of a cell-penetrating anti-RAD51 antibody in PTEN-deficient melanoma and glioma cells Priority Research Paper

Inhibition of ATM kinase upregulates levels of cell death induced by cannabidiol and γ-irradiation in human glioblastoma cells Research Paper

ALT cancer cells are specifically sensitive to lysine acetyl transferase inhibition Research Paper

FGFR1β is a driver isoform of FGFR1 alternative splicing in breast cancer cells Research Paper

Preclinical characterization of tyrosine kinase inhibitor-based targeted therapies for neuroendocrine thyroid cancer Research Paper

KLHL5 knockdown increases cellular sensitivity to anticancer drugs Research Paper

Time to progression to castration-resistant prostate cancer after commencing combined androgen blockade for advanced hormone-sensitive prostate cancer Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

The long non-coding RNA PCA3: an update of its functions and clinical applications as a biomarker in prostate cancer Review

Splicing regulatory factors in breast cancer hallmarks and disease progression Review

The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer Research Paper

Two novel ligand-independent variants of the VEGFR-1 receptor are expressed in human testis and spermatozoa, one of them with the ability to activate SRC proto-oncogene tyrosine kinases Research Paper

Comparison of different semi-automated cfDNA extraction methods in combination with UMI-based targeted sequencing Research Paper

Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells Research Paper

Detection of tyrosine kinase inhibitors-induced COX-2 expression in bladder cancer by fluorocoxib A Research Paper

ALK mutation dynamics and clonal evolution in a neuroblastoma model exhibiting two ALK mutations Research Paper

Oncologist uptake of comprehensive genomic profile guided targeted therapy Research Paper

Modified Simon’s minimax and optimal two-stage designs for single-arm phase II cancer clinical trials Research Paper

Comparative proteomic analysis of human serum before and after liver transplantation using quantitative proteomics Research Paper

A novel anti-melanoma SRC-family kinase inhibitor Research Paper

Application of cell-free DNA for genomic tumor profiling: a feasibility study Research Paper

Synthetic lethality of a cell-penetrating anti-RAD51 antibody in PTEN-deficient melanoma and glioma cells Priority Research Paper

Inhibition of ATM kinase upregulates levels of cell death induced by cannabidiol and γ-irradiation in human glioblastoma cells Research Paper

ALT cancer cells are specifically sensitive to lysine acetyl transferase inhibition Research Paper

FGFR1β is a driver isoform of FGFR1 alternative splicing in breast cancer cells Research Paper

Preclinical characterization of tyrosine kinase inhibitor-based targeted therapies for neuroendocrine thyroid cancer Research Paper

KLHL5 knockdown increases cellular sensitivity to anticancer drugs Research Paper

Time to progression to castration-resistant prostate cancer after commencing combined androgen blockade for advanced hormone-sensitive prostate cancer Research Paper