The Oncosearch | Oncotarget

Normal tissue and tumor microenvironment adaptations to aerobic exercise enhance doxorubicin anti-tumor efficacy and ameliorate its cardiotoxicity in retired breeder mice Priority Research Paper

Zachary R. Wakefield, Mai Tanaka, Christine Pampo, Sharon Lepler, Lori Rice, Joy Guingab-Cagmat, Timothy J. Garrett, Dietmar W. Siemann

Published Aug 18, 2021 · Vol. 12, No. 18 · pp. 1737-1748

Keywords: aerobic exercise, breast cancer, hypoxia, doxorubicin, cardiotoxicity

The antitumoral effects of chemerin are independent from leukocyte recruitment and mediated by inhibition of neoangiogenesis Research Paper

Ingrid Dubois-Vedrenne, Diana Al Delbany, Olivier De Henau, Virginie Robert, Maxime Vernimmen, Francina Langa, Anne Lefort, Frédérick Libert, Valérie Wittamer, Marc Parmentier

Published Aug 18, 2021 · Vol. 12, No. 19 · pp. 1903-1919

Keywords: chemerin, ChemR23, CMKLR1, Rarres2, tumor angiogenesis

High expression of Myosin 1g in pediatric acute lymphoblastic leukemia Research Paper

Laura A. Estrada-Abreo, Leonor Rodríguez-Cruz, Yanelly Garfias-Gómez, Janeth E. Araujo-Cardenas, Gabriela Antonio-Andrés, Alfonso R. Salgado-Aguayo, Darío Orozco-Ruiz, José Refugio Torres-Nava, Juan D. Díaz-Valencia, Sara Huerta-Yépez, Genaro Patiño-López

Published Aug 18, 2021 · Vol. 12, No. 19 · pp. 1937-1945

Keywords: Myosin 1g, acute lymphoblastic leukemia, high risk, biomarker, pediatric

Nanoparticle T cell engagers for the treatment of acute myeloid leukemia Research Paper

Kinan Alhallak, Jennifer Sun, Barbara Muz, Amanda Jeske, Jessica Yavner, Hannah Bash, Chaelee Park, Berit Lubben, Ola Adebayo, Samuel Achilefu, John F. DiPersio, Abdel Kareem Azab

Published Aug 18, 2021 · Vol. 12, No. 19 · pp. 1878-1885

Keywords: acute myeloid leukemia, T cell engagers, nanoparticles, 3D tissue culture model

Anti-aging: senolytics or gerostatics (unconventional view) Review

Mikhail V. Blagosklonny

Published Aug 12, 2021 · Vol. 12, No. 18 · pp. 1821-1835

Keywords: geroscience, senolytics, hyperfunction theory, aging, sirolimus

Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia Research Paper

Taylor J. Chen, Wa Du, Jacob J. Junco, Cory Seth Bridges, Ye Shen, Monica Puppi, Karen R. Rabin, H. Daniel Lacorazza

Published Jul 31, 2021 · Vol. 12, No. 18 · pp. 1787-1801

Keywords: T-ALL, MAP2K7, 5z-7-oxozeaenol

Diverse transcriptional regulation and functional effects revealed by CRISPR/Cas9-directed epigenetic editing Research Paper

Miguel Vizoso, Jacco van Rheenen

Published Jul 29, 2021 · Vol. 12, No. 17 · pp. 1651-1662

Keywords: targeted DNA methylation, CRISPR/Cas9-based system, IGFBP2, epithelial-to-mesenchymal transition

Epigenetic signatures differentiate uterine and soft tissue leiomyosarcoma Research Paper

Nesrin M. Hasan, Anup Sharma, Nensi M. Ruzgar, Hari Deshpande, Kelly Olino, Sajid Khan, Nita Ahuja

Published Jul 21, 2021 · Vol. 12, No. 16 · pp. 1566-1579

Keywords: leiomyosarcoma, epigenetics, DNA methylation, gene expression, uterine leiomyosarcoma

MiR-7-5p inhibits thyroid cell proliferation by targeting the EGFR/MAPK and IRS2/PI3K signaling pathways Research Paper

Alice Augenlicht, Manuel Saiselet, Myriam Decaussin-Petrucci, Guy Andry, Jacques E. Dumont, Carine Maenhaut

Published Jul 17, 2021 · Vol. 12, No. 16 · pp. 1587-1599

Keywords: miRNA, papillary thyroid carcinoma, IRS2, MAPK, PI3K

The impact of neoadjuvant concurrent chemoradiation on exosomal markers (CD63 and CD9) expression and their prognostic significance in patients with rectal adenocarcinoma Research Paper

Moh’d Khushman, Pranitha Prodduturvar, Wadad Mneimneh, Valeria Dal Zotto, Shalla Akbar, Leander Grimm, Paul Rider, John Hunter, Omar Alkharabsheh, Girijesh Kumar Patel, Jesus C. Fabregas, Ajay P. Singh

Published Jun 30, 2021 · Vol. 12, No. 15 · pp. 1490-1498

Keywords: exosomes, exosomal markers, CD63, CD9, neoadjuvant chemoradiation

Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase Research Paper

Yuki Okawa, Nobutaka Ebata, Nayoung K.D. Kim, Masashi Fujita, Kazuhiro Maejima, Shota Sasagawa, Toru Nakamura, Woong-Yang Park, Satoshi Hirano, Hidewaki Nakagawa

Published Jun 28, 2021 · Vol. 12, No. 15 · pp. 1540-1552

Keywords: biliary tract cancer, mutation, immunotherapic biomarker, knowledgebase, molecular targeted therapy

Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells Priority Research Paper

Nikolai Petrov, Hee-Sheung Lee, Mikhail Liskovykh, Marie-Paule Teulade-Fichou, Hiroshi Masumoto, William C. Earnshaw, Yves Pommier, Vladimir Larionov, Natalay Kouprina

Published Jun 27, 2021 · Vol. 12, No. 15 · pp. 1444-1456

Keywords: chromosome instability, CIN, platinum-derived G4-quadruplexes, telomere dysfunction, human artificial chromosome

Neddylation and anti-tumor immunity Research Perspective

Xiaoguang Wang, Scott Best, Alexey V. Danilov

Published Jun 27, 2021 · Vol. 12, No. 21 · pp. 2227-2230

Keywords: neddylation, T cell, pevonedistat

Prokineticin-1 induces normal lymphangiogenic activity and is involved in lymphangiogenesis and lymph node metastasis in colorectal cancer Research Paper

Takayuki Naruse, Takanori Goi, Akio Yamaguchi

Published Jun 23, 2021 · Vol. 12, No. 14 · pp. 1388-1397

Keywords: prokineticin-1, lymphangiogenic activity, colorectal cancer

Mebendazole disrupts stromal desmoplasia and tumorigenesis in two models of pancreatic cancer Research Paper

Tara Williamson, Michelle Carvalho de Abreu, Dimitri G. Trembath, Cory Brayton, Byunghak Kang, Thais Biude Mendes, Paulo Pimentel de Assumpção, Janete M. Cerutti, Gregory J. Riggins

Published Jun 22, 2021 · Vol. 12, No. 14 · pp. 1326-1338

Keywords: mebendazole, pancreatic cancer, cancer prevention, metastasis, mouse models

Correction: Discovery and clinical introduction of first-in-class imipridone ONC201 Correction

Joshua E. Allen, C. Leah B. Kline, Varun V. Prabhu, Jessica Wagner, Jo Ishizawa, Neel Madhukar, Avital Lev, Marie Baumeister, Lanlan Zhou, Amriti Lulla, Martin Stogniew, Lee Schalop, Cyril Benes, Howard L. Kaufman, Richard S. Pottorf, B. Rao Nallaganchu, Gary L. Olson, Fahd Al-Mulla, Madeleine Duvic, Gen Sheng Wu, David T. Dicker, Mala K. Talekar, Bora Lim, Olivier Elemento, Wolfgang Oster, Joseph Bertino, Keith Flaherty, Michael L. Wang, Gautam Borthakur, Michael Andreeff, Mark Stein, Wafik S. El-Deiry

Published Jun 22, 2021 · Vol. 12, No. 21 · pp. 2231-2231

Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis Research Paper

Reza Bayat Mokhtari, Bessi Qorri, Narges Baluch, Angelo Sparaneo, Federico Pio Fabrizio, Lucia Anna Muscarella, Albina Tyker, Sushil Kumar, Hai-Ling Margaret Cheng, Myron R. Szewczuk, Bikul Das, Herman Yeger

Published Jun 22, 2021 · Vol. 12, No. 15 · pp. 1470-1489

Keywords: sulforaphane, acetazolamide, bronchial carcinoid tumors, serotonin, carbonic anhydrase

Esomeprazole enhances the effect of ionizing radiation to improve tumor control Research Paper

Kassidy A. Hebert, Sergio Jaramillo, Wangjie Yu, Min Wang, Ratna Veeramachaneni, Vlad C. Sandulache, Andrew G. Sikora, Mark D. Bonnen, Ananth V. Annapragada, David Corry, Farrah Kheradmand, Raj K. Pandita, Michelle S. Ludwig, Tej K. Pandita, Shixia Huang, Cristian Coarfa, Sandra L. Grimm, Dimuthu Perera, George Miles, Yohannes T. Ghebre

Published Jun 19, 2021 · Vol. 12, No. 14 · pp. 1339-1353

Keywords: esomeprazole, proton pump inhibitors, ionizing radiation, radiosensitization, tumor control

Eltrombopag and its iron chelating properties in pediatric acute myeloid leukemia Research Paper

Maura Argenziano, Chiara Tortora, Alessandra Di Paola, Elvira Pota, Martina Di Martino, Daniela Di Pinto, Caterina Di Leva, Francesca Rossi

Published Jun 16, 2021 · Vol. 12, No. 14 · pp. 1377-1387

Keywords: acute monocytic leukemia, eltrombopag, deferasirox, iron chelation, cancer

Results from a randomized trial combining trastuzumab with a peptide vaccine suggest a role for HER2-targeted therapy in triple-negative breast cancer Editorial

Anne E. O’Shea, Guy T. Clifton, George E. Peoples

Published Jun 15, 2021 · Vol. 12, No. 23 · pp. 2318-2319

Keywords: HER2, peptide vaccines, nelipepimut-S, triple-negative breast cancer

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Normal tissue and tumor microenvironment adaptations to aerobic exercise enhance doxorubicin anti-tumor efficacy and ameliorate its cardiotoxicity in retired breeder mice Priority Research Paper

The antitumoral effects of chemerin are independent from leukocyte recruitment and mediated by inhibition of neoangiogenesis Research Paper

High expression of Myosin 1g in pediatric acute lymphoblastic leukemia Research Paper

Nanoparticle T cell engagers for the treatment of acute myeloid leukemia Research Paper

Anti-aging: senolytics or gerostatics (unconventional view) Review

Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia Research Paper

Diverse transcriptional regulation and functional effects revealed by CRISPR/Cas9-directed epigenetic editing Research Paper

Epigenetic signatures differentiate uterine and soft tissue leiomyosarcoma Research Paper

MiR-7-5p inhibits thyroid cell proliferation by targeting the EGFR/MAPK and IRS2/PI3K signaling pathways Research Paper

The impact of neoadjuvant concurrent chemoradiation on exosomal markers (CD63 and CD9) expression and their prognostic significance in patients with rectal adenocarcinoma Research Paper

Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase Research Paper

Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells Priority Research Paper

Neddylation and anti-tumor immunity Research Perspective

Prokineticin-1 induces normal lymphangiogenic activity and is involved in lymphangiogenesis and lymph node metastasis in colorectal cancer Research Paper

Mebendazole disrupts stromal desmoplasia and tumorigenesis in two models of pancreatic cancer Research Paper

Correction: Discovery and clinical introduction of first-in-class imipridone ONC201 Correction

Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis Research Paper

Esomeprazole enhances the effect of ionizing radiation to improve tumor control Research Paper

Eltrombopag and its iron chelating properties in pediatric acute myeloid leukemia Research Paper

Results from a randomized trial combining trastuzumab with a peptide vaccine suggest a role for HER2-targeted therapy in triple-negative breast cancer Editorial

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Normal tissue and tumor microenvironment adaptations to aerobic exercise enhance doxorubicin anti-tumor efficacy and ameliorate its cardiotoxicity in retired breeder mice Priority Research Paper

The antitumoral effects of chemerin are independent from leukocyte recruitment and mediated by inhibition of neoangiogenesis Research Paper

High expression of Myosin 1g in pediatric acute lymphoblastic leukemia Research Paper

Nanoparticle T cell engagers for the treatment of acute myeloid leukemia Research Paper

Anti-aging: senolytics or gerostatics (unconventional view) Review

Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia Research Paper

Diverse transcriptional regulation and functional effects revealed by CRISPR/Cas9-directed epigenetic editing Research Paper

Epigenetic signatures differentiate uterine and soft tissue leiomyosarcoma Research Paper

MiR-7-5p inhibits thyroid cell proliferation by targeting the EGFR/MAPK and IRS2/PI3K signaling pathways Research Paper

The impact of neoadjuvant concurrent chemoradiation on exosomal markers (CD63 and CD9) expression and their prognostic significance in patients with rectal adenocarcinoma Research Paper

Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase Research Paper

Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells Priority Research Paper

Neddylation and anti-tumor immunity Research Perspective

Prokineticin-1 induces normal lymphangiogenic activity and is involved in lymphangiogenesis and lymph node metastasis in colorectal cancer Research Paper

Mebendazole disrupts stromal desmoplasia and tumorigenesis in two models of pancreatic cancer Research Paper

Correction: Discovery and clinical introduction of first-in-class imipridone ONC201 Correction

Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis Research Paper

Esomeprazole enhances the effect of ionizing radiation to improve tumor control Research Paper

Eltrombopag and its iron chelating properties in pediatric acute myeloid leukemia Research Paper

Results from a randomized trial combining trastuzumab with a peptide vaccine suggest a role for HER2-targeted therapy in triple-negative breast cancer Editorial