The Oncosearch | Oncotarget

TAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades Research Paper

Scott A. Scarneo, Kelly W. Yang, Jose R. Roques, Alanna Dai, Liesl S. Eibschutz, Philip Hughes, Timothy A.J. Haystead

Published May 8, 2020 · Vol. 11, No. 21 · pp. 1961-1970

Keywords: TAK1, breast cancer, therapeutic, inflammation

Adoptive cell therapy in combination with checkpoint inhibitors in ovarian cancer Research Paper

Anders Handrup Kverneland, Magnus Pedersen, Marie Christine Wulff Westergaard, Morten Nielsen, Troels Holz Borch, Lars Rønn Olsen, Gitte Aasbjerg, Saskia J. Santegoets, Sjoerd H. van der Burg, Katy Milne, Brad H. Nelson, Özcan Met, Marco Donia, Inge Marie Svane

Published May 6, 2020 · Vol. 11, No. 22 · pp. 2092-2105

Keywords: adoptive cell therapy, tumor-infiltrating lymphocytes, ovarian cancer, combinational immune therapy, checkpoint inihibors

Second line trastuzumab emtansine following horizontal dual blockade in a real-life setting Research Paper

Salvatore Del Prete, Liliana Montella, Grazia Arpino, Giuseppe Buono, Carlo Buonerba, Pasquale Dolce, Olga Fiorentino, Maria Aliberti, Antonio Febbraro, Clementina Savastano, Giuseppe Colantuoni, Ferdinando Riccardi, Angela Ruggiero, Sabino De Placido, Michele Orditura

Published May 6, 2020 · Vol. 11, No. 22 · pp. 2083-2091

Keywords: breast cancer, metastatic, Her-2 positive, trastuzumab emtansine, pertuzumab

Efficacy of osimertinib against EGFRvIII+ glioblastoma Research Paper

Gustavo Chagoya, Shawn G. Kwatra, Cory W. Nanni, Callie M. Roberts, Samantha M. Phillips, Sarah Nullmeyergh, Samuel P. Gilmore, Ivan Spasojevic, David L. Corcoran, Christopher C. Young, Karla V. Ballman, Rohan Ramakrishna, Darren A. Cross, James M. Markert, Michael Lim, Mark R. Gilbert, Glenn J. Lesser, Madan M. Kwatra

Published May 5, 2020 · Vol. 11, No. 22 · pp. 2074-2082

Keywords: EGFRvIII, tyrosine kinase, glioblastoma stem cells, osimertinib, xenografts

Hyperprogression to a dual immune blockade followed by subsequent response with cabozantinib in metastatic poor-risk clear cell renal cell carcinoma with NOTCH mutation Case Report

Javier Molina-Cerrillo, Teresa Alonso-Gordoa, Alfredo Carrato, Enrique Grande

Published May 4, 2020 · Vol. 11, No. 22 · pp. 2137-2140

Keywords: immunotherapy, renal cell carninoma, cabozantinib, NOTCH

Hereditary pancreatitis model by blastocyst complementation in mouse Research Paper

Ayumu Asai, Masamitsu Konno, Koichi Kawamoto, Ayako Isotani, Masaki Mori, Hidetoshi Eguchi, Yuichiro Doki, Takahiro Arai, Hideshi Ishii

Published May 2, 2020 · Vol. 11, No. 22 · pp. 2061-2073

Keywords: blastocyst complementation, hereditary pancreatitis, disease-specific pluripotent stem cells, PRSS1

Panaxynol, a bioactive component of American ginseng, targets macrophages and suppresses colitis in mice Priority Research Paper

Anusha Chaparala, Deepak Poudyal, Hossam Tashkandi, Erin E. Witalison, Alexander A. Chumanevich, Jenna L. Hofseth, Ivy Nguyen, Olivia Hardy, Douglas L. Pittman, Michael D. Wyatt, Anthony Windust, Elizabeth A. Murphy, Mitzi Nagarkatti, Prakash Nagarkatti, Lorne J. Hofseth

Published Apr 30, 2020 · Vol. 11, No. 22 · pp. 2026-2036

Keywords: inflammatory bowel diseases, ulcerative colitis, American ginseng, panaxynol, macrophages

Inhibition of HAS2 and hyaluronic acid production by 1,25-Dihydroxyvitamin D₃ in breast cancer Research Paper

Carmen J. Narvaez, Erika LaPorta, Samantha Robilotto, Jennifer Liang, JoEllen Welsh

Published Apr 25, 2020 · Vol. 11, No. 30 · pp. 2889-2905

Keywords: vitamin D, hyaluronic acid, hyaluronan synthase, HAS2, breast cancer

An exploratory study of metformin with or without rapamycin as maintenance therapy after induction chemotherapy in patients with metastatic pancreatic adenocarcinoma Priority Research Paper

Katherine M. Bever, Erkut H. Borazanci, Elizabeth A. Thompson, Jennifer N. Durham, Kimberly Pinero, Gayle S. Jameson, Amber Vrana, Meizheng Liu, Cara Wilt, Annie A. Wu, Wei Fu, Hao Wang, Yafu Yin, Jeffrey P. Leal, Ana De Jesus-Acosta, Lei Zheng, Daniel A. Laheru, Daniel D. Von Hoff, Elizabeth M. Jaffee, Jonathan D. Powell, Dung T. Le

Published Apr 23, 2020 · Vol. 11, No. 21 · pp. 1929-1941

Keywords: pancreatic cancer, mTOR inhibition, maintenance therapy, metformin

Immunotherapy of ovarian cancer with a monoclonal antibody specific for the extracellular domain of anti-Müllerian hormone receptor II Research Paper

Suparna Mazumder, Valerie Swank, Anton A. Komar, Justin M. Johnson, Vincent K. Tuohy

Published Apr 22, 2020 · Vol. 11, No. 20 · pp. 1894-1910

Keywords: monoclonal antibody, anti-Müllerian hormone receptor type II, immunotherapy, ovarian cancer, 4D12G1

Aberrant epigenetic silencing of neuronatin is a frequent event in human osteosarcoma Research Paper

Haleema Saeed, Sayantani Sinha, Christine Mella, Jeffrey S. Kuerbitz, Monica L. Cales, Mark A. Steele, Jennifer Stanke, Derek Damron, Fayez Safadi, Steven J. Kuerbitz

Published Apr 22, 2020 · Vol. 11, No. 20 · pp. 1876-1893

Keywords: osteosarcoma, DNA methylation, neuronatin, tumor suppressor genes

PLAC1 is essential for FGF7/FGFRIIIb-induced Akt-mediated cancer cell proliferation Research Paper

Diana Barea Roldán, Matthias Grimmler, Christoph Hartmann, Stefanie Hubich-Rau, Tim Beißert, Claudia Paret, Giuseppe Cagna, Christoph Rohde, Stefan Wöll, Michael Koslowski, Özlem Türeci, Ugur Sahin

Published Apr 22, 2020 · Vol. 11, No. 20 · pp. 1862-1875

Keywords: PLAC1, tumorigenesis, extracellular matrix, fibroblast growth factor, AKT

Nutlin-3a suppresses poly (ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1 suppressors in a human breast cancer cell line Research Paper

Masaki Kobayashi, Yuka Ishizaki, Mika Owaki, Yoko Matsumoto, Yuri Kakiyama, Shunsuke Hoshino, Ryoma Tagawa, Yuka Sudo, Naoyuki Okita, Kazunori Akimoto, Yoshikazu Higami

Published Apr 22, 2020 · Vol. 11, No. 18 · pp. 1653-1665

Keywords: nutlin-3a, PARP1, breast cancer, proteasomal degradation, autoPARylation

Small molecule inhibits T-cell acute lymphoblastic leukaemia oncogenic interaction through conformational modulation of LMO2 Research Paper

Leanne Milton-Harris, Mark Jeeves, Sarah A. Walker, Simon E. Ward, Erika J. Mancini

Published Apr 22, 2020 · Vol. 11, No. 19 · pp. 1737-1748

Keywords: protein-protein interaction, leukaemia, T-ALL, drug discovery, LMO2

Aberrant epigenetic silencing of neuronatin is a frequent event in human osteosarcoma Research Paper

Haleema Saeed, Sayantani Sinha, Christine Mella, Jeffrey S. Kuerbitz, Monica L. Cales, Mark A. Steele, Jennifer Stanke, Derek Damron, Fayez Safadi, Steven J. Kuerbitz

Published Apr 22, 2020

Keywords: osteosarcoma, DNA methylation, neuronatin, tumor suppressor genes

Lymph nodes may be a source for immunetherapy in gastric cancer Research Paper

Paula Baraúna Assumpção, Erika Couto Canelas, Aline Cruz Ramos, Ana Anaissi, João Felipe Acioli, Geraldo Ishak, Sidney Santos, Samia Demachki, Paulo Assumpção

Published Apr 21, 2020 · Vol. 11, No. 19 · pp. 1729-1736

Keywords: gastric cancer, immunotherapy, lymph nodes

Synergistic combinations of paclitaxel and withaferin A against human non-small cell lung cancer cells Research Paper

Al Hassan Kyakulaga, Farrukh Aqil, Radha Munagala, Ramesh C. Gupta

Published Apr 21, 2020 · Vol. 11, No. 16 · pp. 1399-1416

Keywords: non-small cell lung cancer, withaferin A, synergistic, combination index, paclitaxel

Characterization of GRK5 as a novel regulator of rhabdomyosarcoma tumor cell growth and self-renewal Research Paper

Thao Pham, Kristin Robinson, Terra Vleeshouwer-Neumann, James E. Annis, Eleanor Y. Chen

Published Apr 21, 2020 · Vol. 11, No. 16 · pp. 1448-1461

Keywords: rhabdomyosarcoma, self-renewal, GRK5, kinase, cell cycle

Distinct pattern of one-carbon metabolism, a nutrient-sensitive pathway, in invasive breast cancer: A metabolomic study Research Paper

Jéssica Reis Santos, Dan Linetzky Waitzberg, Ismael Dale Cotrim Guerreiro da Silva, Tharcisio Citrangulo Tortelli Junior, Luciana Rodrigues Carvalho Barros, Gisele André Baptista Canuto, Andréa Tedesco Faccio, Lydia Fumiko Yamaguchi, Massuo Jorge Kato, Marina Franco Maggi Tavares, Ana Cristina Martinez, Ângela Flavia Logullo, Raquel Suzana M.M. Torrinhas, Graziela Ravacci

Published Apr 18, 2020 · Vol. 11, No. 18 · pp. 1637-1652

Keywords: invasive ductal carcinoma, targeted metabolomics, untargeted metabolomics, tumor metabolism, one-carbon metabolism

Knock-down of the TIM/TIPIN complex promotes apoptosis in melanoma cells Research Paper

Abhijit Chakraborty, Faisal Aziz, Eunmiri Roh, Le Thi My Le, Raja Dey, Tianshun Zhang, Moeez G. Rathore, Aalekhya Sharma Biswas, Ann M. Bode, Zigang Dong

Published Apr 17, 2020 · Vol. 11, No. 20 · pp. 1846-1861

Keywords: TIMELESS, TIPIN, apoptosis, xenograft, Cryo-EM

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TAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades Research Paper

Adoptive cell therapy in combination with checkpoint inhibitors in ovarian cancer Research Paper

Second line trastuzumab emtansine following horizontal dual blockade in a real-life setting Research Paper

Efficacy of osimertinib against EGFRvIII+ glioblastoma Research Paper

Hyperprogression to a dual immune blockade followed by subsequent response with cabozantinib in metastatic poor-risk clear cell renal cell carcinoma with NOTCH mutation Case Report

Hereditary pancreatitis model by blastocyst complementation in mouse Research Paper

Panaxynol, a bioactive component of American ginseng, targets macrophages and suppresses colitis in mice Priority Research Paper

Inhibition of HAS2 and hyaluronic acid production by 1,25-Dihydroxyvitamin D₃ in breast cancer Research Paper

An exploratory study of metformin with or without rapamycin as maintenance therapy after induction chemotherapy in patients with metastatic pancreatic adenocarcinoma Priority Research Paper

Immunotherapy of ovarian cancer with a monoclonal antibody specific for the extracellular domain of anti-Müllerian hormone receptor II Research Paper

Aberrant epigenetic silencing of neuronatin is a frequent event in human osteosarcoma Research Paper

PLAC1 is essential for FGF7/FGFRIIIb-induced Akt-mediated cancer cell proliferation Research Paper

Nutlin-3a suppresses poly (ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1 suppressors in a human breast cancer cell line Research Paper

Small molecule inhibits T-cell acute lymphoblastic leukaemia oncogenic interaction through conformational modulation of LMO2 Research Paper

Aberrant epigenetic silencing of neuronatin is a frequent event in human osteosarcoma Research Paper

Lymph nodes may be a source for immunetherapy in gastric cancer Research Paper

Synergistic combinations of paclitaxel and withaferin A against human non-small cell lung cancer cells Research Paper

Characterization of GRK5 as a novel regulator of rhabdomyosarcoma tumor cell growth and self-renewal Research Paper

Distinct pattern of one-carbon metabolism, a nutrient-sensitive pathway, in invasive breast cancer: A metabolomic study Research Paper

Knock-down of the TIM/TIPIN complex promotes apoptosis in melanoma cells Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

TAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades Research Paper

Adoptive cell therapy in combination with checkpoint inhibitors in ovarian cancer Research Paper

Second line trastuzumab emtansine following horizontal dual blockade in a real-life setting Research Paper

Efficacy of osimertinib against EGFRvIII+ glioblastoma Research Paper

Hyperprogression to a dual immune blockade followed by subsequent response with cabozantinib in metastatic poor-risk clear cell renal cell carcinoma with NOTCH mutation Case Report

Hereditary pancreatitis model by blastocyst complementation in mouse Research Paper

Panaxynol, a bioactive component of American ginseng, targets macrophages and suppresses colitis in mice Priority Research Paper

Inhibition of HAS2 and hyaluronic acid production by 1,25-Dihydroxyvitamin D3 in breast cancer Research Paper

An exploratory study of metformin with or without rapamycin as maintenance therapy after induction chemotherapy in patients with metastatic pancreatic adenocarcinoma Priority Research Paper

Immunotherapy of ovarian cancer with a monoclonal antibody specific for the extracellular domain of anti-Müllerian hormone receptor II Research Paper

Aberrant epigenetic silencing of neuronatin is a frequent event in human osteosarcoma Research Paper

PLAC1 is essential for FGF7/FGFRIIIb-induced Akt-mediated cancer cell proliferation Research Paper

Nutlin-3a suppresses poly (ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1 suppressors in a human breast cancer cell line Research Paper

Small molecule inhibits T-cell acute lymphoblastic leukaemia oncogenic interaction through conformational modulation of LMO2 Research Paper

Aberrant epigenetic silencing of neuronatin is a frequent event in human osteosarcoma Research Paper

Lymph nodes may be a source for immunetherapy in gastric cancer Research Paper

Synergistic combinations of paclitaxel and withaferin A against human non-small cell lung cancer cells Research Paper

Characterization of GRK5 as a novel regulator of rhabdomyosarcoma tumor cell growth and self-renewal Research Paper

Distinct pattern of one-carbon metabolism, a nutrient-sensitive pathway, in invasive breast cancer: A metabolomic study Research Paper

Knock-down of the TIM/TIPIN complex promotes apoptosis in melanoma cells Research Paper

Inhibition of HAS2 and hyaluronic acid production by 1,25-Dihydroxyvitamin D₃ in breast cancer Research Paper