The Oncosearch | Oncotarget

Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells Research Paper

GisÃ¨le Montavon, Nicolas Jauquier, AurÃ©lie Coulon, Michel Peuchmaur, Marjorie Flahaut, Katia Balmas Bourloud, Pu Yan, Olivier Delattre, Lukas Sommer, Jean-Marc Joseph, Isabelle Janoueix-Lerosey, Nicole Gross, Annick MÃ¼hlethaler-Mottet

Published May 27, 2014 · Vol. 5, No. 12 · pp. 4452-4466

Identification of a gene expression driven progression pathway in myxoid liposarcoma Research Paper

Loris De Cecco, Tiziana Negri, Silvia Brich, Valentina Mauro, Fabio Bozzi, GianPaolo Dagrada, Vittoria Disciglio, Roberta Sanfilippo, Alessandro Gronchi, Maurizio Dâ€™Incalci, Paolo G. Casali, Silvana Canevari, Marco A. Pierotti, Silvana Pilotti

Published May 27, 2014 · Vol. 5, No. 15 · pp. 5965-5977

Histone deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1 Research Paper

Jeyran Shahbazi, Christopher J. Scarlett, Murray D. Norris, Bing Liu, Michelle Haber, Andrew E. Tee, Alice Carrier, Andrew V. Biankin, Wendy B. London, Glenn M. Marshall, Richard B. Lock, Tao Liu

Published May 20, 2014 · Vol. 5, No. 12 · pp. 4257-4268

HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib Research Paper

Alberto RamÃrez, Houria Boulaiz, Cynthia Morata-Tarifa, Macarena PerÃ¡n, Gema JimÃ©nez, Manuel Picon-Ruiz, Ahmad Agil, Olga Cruz-LÃ³pez, Ana Conejo-GarcÃa, JoaquÃn M. Campos, Ana SÃ¡nchez, MarÃa A. GarcÃa, Juan A. Marchal

Published May 13, 2014 · Vol. 5, No. 11 · pp. 3590-3606

Combination of PIM and JAK2 inhibitors synergistically suppresses cell proliferation and overcomes drug resistance of myeloproliferative neoplasms Research Paper

Shih-Min A. Huang, Anlai Wang, Rita Greco, Zhifang Li, Claude Barberis, Michel Tabart, Vinod Patel, Laurent Schio, Raelene Hurley, Hong Cheng, Christoph Lengauer, Jack Pollard, James Watters, Carlos Garcia-Echeverria, Dmitri Wiederschain, Francisco Adrian, JingXin Zhang

Published May 8, 2014 · Vol. 5, No. 10 · pp. 3362-3374

Unique molecular signatures as a hallmark of patients with metastatic breast cancer: Implications for current treatment paradigms Research Perspective

Jennifer J. Wheler, Barbara A. Parker, Jack J. Lee, Johnique T. Atkins, Filip Janku, Apostolia M. Tsimberidou, Ralph Zinner, Vivek Subbiah, Siqing Fu, Richard Schwab, Stacy Moulder, Vicente Valero, Maria Schwaederle, Roman Yelensky, Vincent A. Miller, M Philip J. Stephens, Funda Meric-Bernstam, Razelle Kurzrock

Published May 2, 2014 · Vol. 5, No. 9 · pp. 2349-2354

Epigenetic silencing of the non-coding RNA nc886 provokes oncogenes during human esophageal tumorigenesis Research Paper

Hyun-Sung Lee, Kwanbok Lee, Hee-Jin Jang, Geon Kook Lee, Jong-Lyul Park, Seon-Young Kim, Sang-Bae Kim, Betty H. Johnson, Jae Ill Zo, Ju-Seog Lee, Yong Sun Lee

Published Apr 27, 2014 · Vol. 5, No. 11 · pp. 3472-3481

Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma Research Paper

Alex Cazes, Lucille Lopez-Delisle, Konstantina Tsarovina, CÃ©cile Pierre-EugÃ¨ne, Katleen De Preter, Michel Peuchmaur, AndrÃ© Nicolas, Claire Provost, Caroline Louis-Brennetot, Romain Daveau, Candy Kumps, Ilaria Cascone, Gudrun Schleiermacher, AurÃ©lie Prignon, Frank Speleman, Hermann Rohrer, Olivier Delattre, Isabelle Janoueix-Lerosey

Published Apr 2, 2014 · Vol. 5, No. 9 · pp. 2688-2702

Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma Research Paper

Sujatha Venataraman, Irina Alimova, Peter Harris, Diane K Birks, Illango Balakrishnan, Marc Remke, Michael D Taylor, Michael Handler, Nicholas K Foreman, Rajeev Vibhakar

Published Mar 31, 2014 · Vol. 5, No. 9 · pp. 2355-2371

Keywords: Medulloblastoma, Myc, BRD4, JQ1, Senescence

Therapeutic Targeting of c-Myc in T-Cell Acute Lymphoblastic Leukemia (T-ALL) Research Paper

Marie Loosveld, RÃ©my Castellano, StÃ©phanie Gon, Armelle Goubard, Thomas Crouzet, Laurent Pouyet, Thomas Prebet, Norbert Vey, Bertrand Nadel, Yves Collette, Dominique Payet-Bornet

Published Mar 27, 2014 · Vol. 5, No. 10 · pp. 3168-3172

Metformin-induced metabolic reprogramming of chemoresistant ALDH^bright breast cancer cells Research Paper

Mario Cioce, MariaCristina Valerio, Luca Casadei, Claudio Pulito, Andrea Sacconi, Federica Mori, Francesca Biagioni, Cesare Manetti, Paola Muti, Sabrina Strano, Giovanni Blandino

Published Mar 26, 2014 · Vol. 5, No. 12 · pp. 4129-4143

Aberrant regulation of FBW7 in cancer Review

Lixia Wang, Xiantao Ye, Yueyong Liu, Wenyi Wei, Zhiwei Wang

Published Mar 25, 2014 · Vol. 5, No. 8 · pp. 2000-2015

Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer Research Paper

Jiankun Gao, Asfar S. Azmi, Amro Aboukameel, Michael Kauffman, Sharon Shacham, Abdul-Badi Abou-Samra, Ramzi M. Mohammad

Published Mar 21, 2014 · Vol. 5, No. 11 · pp. 3444-3454

Anastrozole and everolimus in advanced gynecologic and breast malignancies: activity and molecular alterations in the PI3K/AKT/mTOR pathway Research Paper

Jennifer J. Wheler, Stacy L. Moulder, Aung Naing, Filip Janku, Sarina A. Piha-Paul, Gerald S. Falchook, Ralph Zinner, Apostolia M. Tsimberidou, Siqing Fu, David S. Hong, Johnique T. Atkins, Roman Yelensky, Philip J. Stephens, Razelle Kurzrock

Published Mar 14, 2014 · Vol. 5, No. 10 · pp. 3029-3038

Arsenic-induced sub-lethal stress reprograms human bronchial epithelial cells to CD61Â¯ cancer stem cells Research Paper

Qingshan Chang, Bailing Chen, Chitra Thakur, Yongju Lu, Fei Chen

Published Feb 19, 2014 · Vol. 5, No. 5 · pp. 1290-1303

The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1 Research Paper

Andrew E. Tee, Dora Ling, Charlotte Nelson, Bernard Atmadibrata, Marcel E. Dinger, Ning Xu, Tamio Mizukami, Pei Y. Liu, Bing Liu, Belamy Cheung, Eddy Pasquier, Michelle Haber, Murray D. Norris, Takayoshi Suzuki, Glenn M. Marshall, Tao Liu

Published Feb 18, 2014 · Vol. 5, No. 7 · pp. 1793-1804

Antitumor activity of the c-Myc inhibitor KSI-3716 in gemcitabine-resistant bladder cancer Research Paper

Ho Kyung Seo, Kyung-Ohk Ahn, Nae-Rae Jung, Ji-Sun Shin, Weon Seo Park, Kang-Hyun Lee, Sang-Jin Lee, Kyung-Chae Jeong

Published Jan 16, 2014 · Vol. 5, No. 2 · pp. 326-337

Keywords: Bladder cancer, c-Myc, inhibitor, gemcitabine, gemcitabine resistance

Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth Research Paper

David Vindrieux, Guillaume Devailly, Arnaud Augert, Benjamin Le Calve, Mylene Ferrand, Pascal Pigny, Lea Payen, Gerard Lambeau, Michael Perrais, Sebastien Aubert, HÃ©lÃ¨ne Simonnet, Robert Dante, David Bernard

Published Jan 16, 2014 · Vol. 5, No. 4 · pp. 1004-1013

Keywords: VHL, MYC, HIF, PLA2R1, tumor suppressor

NF-ÎºB1 inhibits c-Myc protein degradation through suppression of FBW7 expression Research Paper

Haishan Huang, Li Ma, Jingxia Li, Yonghui Yu, Dongyun Zhang, Jinlong Wei, Honglei Jin, Derek Xu, Jinmin Gao, Chuanshu Huang

Published Jan 15, 2014 · Vol. 5, No. 2 · pp. 493-505

Keywords: NF-ÎºB p50, arsenite, c-Myc, protein degradation, FBW7

RB1 gene inactivation by chromothripsis in human retinoblastoma Research Paper

Justina McEvoy, Panduka Nagahawatte, David Finkelstein, Jennifer Richards-Yutz, Marcus Valentine, Jing Ma, Charles Mullighan, Guangchun Song, Xiang Chen, Matthew Wilson, Rachel Brennan, Stanely Pounds, Jared Becksfort, Robert Huether, Charles Lu, Robert S. Fulton, Lucinda L. Fulton, Xin Hong, David J. Dooling, Kerri Ochoa, Elaine R. Mardis, Richard K. Wilson, John Easton, Jinghui Zhang, James R. Downing, Arupa Ganguly, Michael A. Dyer

Published Jan 11, 2014 · Vol. 5, No. 2 · pp. 438-450

Keywords: chromothripsis, retinoblastoma, RB1, MYCN

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Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells Research Paper

Identification of a gene expression driven progression pathway in myxoid liposarcoma Research Paper

Histone deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1 Research Paper

HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib Research Paper

Combination of PIM and JAK2 inhibitors synergistically suppresses cell proliferation and overcomes drug resistance of myeloproliferative neoplasms Research Paper

Unique molecular signatures as a hallmark of patients with metastatic breast cancer: Implications for current treatment paradigms Research Perspective

Epigenetic silencing of the non-coding RNA nc886 provokes oncogenes during human esophageal tumorigenesis Research Paper

Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma Research Paper

Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma Research Paper

Therapeutic Targeting of c-Myc in T-Cell Acute Lymphoblastic Leukemia (T-ALL) Research Paper

Metformin-induced metabolic reprogramming of chemoresistant ALDH^bright breast cancer cells Research Paper

Aberrant regulation of FBW7 in cancer Review

Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer Research Paper

Anastrozole and everolimus in advanced gynecologic and breast malignancies: activity and molecular alterations in the PI3K/AKT/mTOR pathway Research Paper

Arsenic-induced sub-lethal stress reprograms human bronchial epithelial cells to CD61Â¯ cancer stem cells Research Paper

The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1 Research Paper

Antitumor activity of the c-Myc inhibitor KSI-3716 in gemcitabine-resistant bladder cancer Research Paper

Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth Research Paper

NF-ÎºB1 inhibits c-Myc protein degradation through suppression of FBW7 expression Research Paper

RB1 gene inactivation by chromothripsis in human retinoblastoma Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells Research Paper

Identification of a gene expression driven progression pathway in myxoid liposarcoma Research Paper

Histone deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1 Research Paper

HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib Research Paper

Combination of PIM and JAK2 inhibitors synergistically suppresses cell proliferation and overcomes drug resistance of myeloproliferative neoplasms Research Paper

Unique molecular signatures as a hallmark of patients with metastatic breast cancer: Implications for current treatment paradigms Research Perspective

Epigenetic silencing of the non-coding RNA nc886 provokes oncogenes during human esophageal tumorigenesis Research Paper

Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma Research Paper

Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma Research Paper

Therapeutic Targeting of c-Myc in T-Cell Acute Lymphoblastic Leukemia (T-ALL) Research Paper

Metformin-induced metabolic reprogramming of chemoresistant ALDHbright breast cancer cells Research Paper

Aberrant regulation of FBW7 in cancer Review

Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer Research Paper

Anastrozole and everolimus in advanced gynecologic and breast malignancies: activity and molecular alterations in the PI3K/AKT/mTOR pathway Research Paper

Arsenic-induced sub-lethal stress reprograms human bronchial epithelial cells to CD61Â¯ cancer stem cells Research Paper

The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1 Research Paper

Antitumor activity of the c-Myc inhibitor KSI-3716 in gemcitabine-resistant bladder cancer Research Paper

Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth Research Paper

NF-ÎºB1 inhibits c-Myc protein degradation through suppression of FBW7 expression Research Paper

RB1 gene inactivation by chromothripsis in human retinoblastoma Research Paper

Metformin-induced metabolic reprogramming of chemoresistant ALDH^bright breast cancer cells Research Paper