The Oncosearch | Oncotarget

Head to head evaluation of second generation ALK inhibitors brigatinib and alectinib as first-line treatment for ALK+ NSCLC using an in silico systems biology-based approach Research Paper

Enric Carcereny, Alonso Fernández-Nistal, Araceli López, Carmen Montoto, Andrea Naves, Cristina Segú-Vergés, Mireia Coma, Guillem Jorba, Baldomero Oliva, Jose Manuel Mas

Published Jan 22, 2021 · Vol. 12, No. 4 · pp. 316-332

Keywords: ALK inhibitor, brigatinib, alectinib, mathematical model, systems biology

High-fat diet-fed ovariectomized mice are susceptible to accelerated subcutaneous tumor growth potentially through adipose tissue inflammation, local insulin-like growth factor release, and tumor associated macrophages Research Paper

Jackie Bader, Meredith Carson, Reilly Enos, Kandy Velazquez, Alexander Sougiannis, Udai Singh, William Becker, Mitzi Nagarkatti, Daping Fan, Angela Murphy

Published Nov 24, 2020 · Vol. 11, No. 49 · pp. 4554-4569

Keywords: colorectal cancer, obesity, metabolism, macrophage, inflammation

Correction: Growth differentiation factor 15 mediates epithelial mesenchymal transition and invasion of breast cancers through IGF-1R-FoxM1 signaling Correction

Bridgette F. Peake, Siobhan M. Eze, Lily Yang, Robert C. Castellino, Rita Nahta

Published Oct 9, 2020 · Vol. 11, No. 44 · pp. 4074-4075

Important players in carcinogenesis as potential targets in cancer therapy: an update Review

Justyna Magdalena Hermanowicz, Iwona Kwiatkowska, Dariusz Pawlak

Published Jul 21, 2020 · Vol. 11, No. 32 · pp. 3078-3101

Keywords: modulators of carcinogenesis, acetylcholine, peroxisome proliferator-activated receptors, aquaporins

IGF-1 and hyperglycaemia-induced FOXA1 and IGFBP-2 affect epithelial to mesenchymal transition in prostate epithelial cells Research Paper

Rehanna Mansor, Jeff Holly, Rachel Barker, Kalina Biernacka, Hanna Zielinska, Anthony Koupparis, Edward Rowe, Jon Oxley, Alex Sewell, Richard M. Martin, Athene Lane, Lucy Hackshaw-McGeagh, Claire Perks

Published Jun 11, 2020 · Vol. 11, No. 26 · pp. 2543-2559

Keywords: hyperglycaemia, prostate cancer, FOXA1, IGFBP-2, EMT

Tumor suppressor p53 regulates insulin receptor (INSR) gene expression via direct binding to the INSR promoter Research Paper

Rive Sarfstein, Haim Werner

Published Jun 9, 2020 · Vol. 11, No. 25 · pp. 2424-2437

Keywords: insulin, insulin-like growth factor-1 (IGF1), insulin receptor, IGF1 receptor, p53

BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer Research Paper

Mai Ahmed Shafei, Thomas Forshaw, Jasmine Davis, Arwa Flemban, David Qualtrough, Sarah Dean, Claire Perks, Ming Dong, Robert Newman, Myra Elizabeth Conway

Published May 8, 2020 · Vol. 11, No. 21 · pp. 1971-1987

Keywords: BCAT, PI3K-AKT, ERK, breast cancer

Protein phosphatase 1 regulatory subunit 1A regulates cell cycle progression in Ewing sarcoma Research Paper

Wen Luo, Changxin Xu, Sarah Phillips, Aliza Gardenswartz, Jeremy M. Rosenblum, Janet Ayello, Stephen L. Lessnick, Huai-Xiang Hao, Mitchell S. Cairo

Published Apr 16, 2020 · Vol. 11, No. 19 · pp. 1691-1704

Keywords: PPP1R1A, cell cycle control, IGF-1R, metastasis, Ewing sarcoma

Proteomic analysis of combined IGF1 receptor targeted therapy and chemotherapy identifies signatures associated with survival in breast cancer patients Research Paper

Tali Sinai-Livne, Metsada Pasmanik-Chor, Zoya Cohen, Ilan Tsarfaty, Haim Werner, Raanan Berger

Published Apr 13, 2020 · Vol. 11, No. 17 · pp. 1515-1530

Keywords: insulin-like growth factor-1 (IGF1), IGF1 receptor (IGF1R), targeted therapy, breast cancer, proteomic analysis

A phase II randomized clinical trial using aglycone isoflavones to treat patients with localized prostate cancer in the pre-surgical period prior to radical prostatectomy Research Paper

Nagi B. Kumar, Julio Pow-Sang, Philippe Spiess, Shohreh Dickinson, Michael J. Schell

Published Apr 7, 2020 · Vol. 11, No. 14 · pp. 1218-1234

Keywords: isoflavones, chemoprevention, prostate cancer, African American men, Caucasian men

Correction: Wogonoside prevents colitis-associated colorectal carcinogenesis and colon cancer progression in inflammation-related microenvironment via inhibiting NF-κB activation through PI3K/Akt pathway Correction

Yang Sun, Yue Zhao, Xiaoping Wang, Li Zhao, Wenjun Li, Youxiang Ding, Lingyi Kong, Qinglong Guo, Na Lu

Published Dec 3, 2019

Esophageal 3D organoids of MPV17^-/- mouse model of mitochondrial DNA depletion show epithelial cell plasticity and telomere attrition Research Paper

Manti Guha, Satish Srinivasan, Maura M. Sheehan, Takashi Kijima, Gordon Ruthel, Kelly Whelan, Koji Tanaka, Andres Klein-Szanto, Prasanna M. Chandramouleeswaran, Hiroshi Nakagawa, Narayan G. Avadhani

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6245-6259

Keywords: mitochondrial DNA, MPV17, ESCC, telomere, 3D organoid

Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells Research Paper

Piyush More, Ute Goedtel-Armbrust, Viral Shah, Marianne Mathaes, Thomas Kindler, Miguel A. Andrade-Navarro, Leszek Wojnowski

Published Sep 3, 2019 · Vol. 10, No. 51 · pp. 5298-5312

Keywords: topoisomerase II poisons, DNA damage, gene expression, combination therapy, cancer essentiality

Vascular endothelium function among male carriers of BRCA 1&2 germline mutation Research Paper

Guy Witberg, Eli Lev, Yaara Ber, Tzlil Tabachnik, Sivan Sela, Ira Belo, Dorit Leshem-Lev, David Margel

Published Aug 20, 2019 · Vol. 10, No. 49 · pp. 5041-5051

Keywords: BRCA, DNA repair, endothelial progenitor cells, vascular endothelium damage, cardiovascular system

Identification of ZYG11A as a candidate IGF1-dependent proto-oncogene in endometrial cancer Research Paper

Laris Achlaug, Rive Sarfstein, Karthik Nagaraj, Lena Lapkina-Gendler, Ilan Bruchim, Manisha Dixit, Zvi Laron, Shoshana Yakar, Haim Werner

Published Jul 9, 2019 · Vol. 10, No. 43 · pp. 4437-4448

Keywords: insulin-like growth factor-1 (IGF1), IGF1 receptor, ZYG11A, p53, endometrial cancer

Correction: Glucocorticoid impairs cell-cell communication by autophagy-mediated degradation of connexin 43 in osteocytes Correction

Junjie Gao, Tak Sum Cheng, An Qin, Nathan J. Pavlos, Tao Wang, Kai Song, Yan Wang, Lianzhi Chen, Lin Zhou, Qing Jiang, Hiroshi Takayanagi, Sheng Yan, Minghao Zheng

Published Jun 12, 2019 · Vol. 10, No. 40 · pp. 4079-4079

Comparing progression molecular mechanisms between lung adenocarcinoma and lung squamous cell carcinoma based on genetic and epigenetic networks: big data mining and genome-wide systems identification Research Paper

Shan-Ju Yeh, Chien-An Chang, Cheng-Wei Li, Lily Hui-Ching Wang, Bor-Sen Chen

Published Jun 4, 2019 · Vol. 10, No. 38 · pp. 3760-3806

Keywords: lung adenocarcinoma, lung squamous cell carcinoma, NSCLC, genetic and epigenetic network, potential drug target

Comparing progression molecular mechanisms between lung adenocarcinoma and lung squamous cell carcinoma based on genetic and epigenetic networks: big data mining and genome-wide systems identification Research Paper

Shan-Ju Yeh, Chien-An Chang, Cheng-Wei Li, Lily Hui-Ching Wang, Bor-Sen Chen

Published May 17, 2019

Keywords: lung adenocarcinoma, lung squamous cell carcinoma, NSCLC, genetic and epigenetic network, potential drug target

Distinct mechanisms by which two forms of miR-140 suppress the malignant properties of lung cancer cells Research Paper

Valentina Flamini, Ed Dudley, Wen G. Jiang, Yuxin Cui

Published Nov 23, 2018 · Vol. 9, No. 92 · pp. 36474-36491

Genome-wide association analysis identifies SNPs predictive of in vitro leukemic cell sensitivity to cytarabine in pediatric AML Research Paper

Salma A. Bargal, Roya Rafiee, Kristine R. Crews, Huiyun Wu, Xueyuan Cao, Jeffrey E. Rubnitz, Raul C. Ribeiro, James R. Downing, Stanley B. Pounds, Jatinder K. Lamba

Published Oct 9, 2018 · Vol. 9, No. 79 · pp. 34859-34875

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Head to head evaluation of second generation ALK inhibitors brigatinib and alectinib as first-line treatment for ALK+ NSCLC using an in silico systems biology-based approach Research Paper

High-fat diet-fed ovariectomized mice are susceptible to accelerated subcutaneous tumor growth potentially through adipose tissue inflammation, local insulin-like growth factor release, and tumor associated macrophages Research Paper

Correction: Growth differentiation factor 15 mediates epithelial mesenchymal transition and invasion of breast cancers through IGF-1R-FoxM1 signaling Correction

Important players in carcinogenesis as potential targets in cancer therapy: an update Review

IGF-1 and hyperglycaemia-induced FOXA1 and IGFBP-2 affect epithelial to mesenchymal transition in prostate epithelial cells Research Paper

Tumor suppressor p53 regulates insulin receptor (INSR) gene expression via direct binding to the INSR promoter Research Paper

BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer Research Paper

Protein phosphatase 1 regulatory subunit 1A regulates cell cycle progression in Ewing sarcoma Research Paper

Proteomic analysis of combined IGF1 receptor targeted therapy and chemotherapy identifies signatures associated with survival in breast cancer patients Research Paper

A phase II randomized clinical trial using aglycone isoflavones to treat patients with localized prostate cancer in the pre-surgical period prior to radical prostatectomy Research Paper

Correction: Wogonoside prevents colitis-associated colorectal carcinogenesis and colon cancer progression in inflammation-related microenvironment via inhibiting NF-κB activation through PI3K/Akt pathway Correction

Esophageal 3D organoids of MPV17^-/- mouse model of mitochondrial DNA depletion show epithelial cell plasticity and telomere attrition Research Paper

Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells Research Paper

Vascular endothelium function among male carriers of BRCA 1&2 germline mutation Research Paper

Identification of ZYG11A as a candidate IGF1-dependent proto-oncogene in endometrial cancer Research Paper

Correction: Glucocorticoid impairs cell-cell communication by autophagy-mediated degradation of connexin 43 in osteocytes Correction

Comparing progression molecular mechanisms between lung adenocarcinoma and lung squamous cell carcinoma based on genetic and epigenetic networks: big data mining and genome-wide systems identification Research Paper

Comparing progression molecular mechanisms between lung adenocarcinoma and lung squamous cell carcinoma based on genetic and epigenetic networks: big data mining and genome-wide systems identification Research Paper

Distinct mechanisms by which two forms of miR-140 suppress the malignant properties of lung cancer cells Research Paper

Genome-wide association analysis identifies SNPs predictive of in vitro leukemic cell sensitivity to cytarabine in pediatric AML Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Head to head evaluation of second generation ALK inhibitors brigatinib and alectinib as first-line treatment for ALK+ NSCLC using an in silico systems biology-based approach Research Paper

High-fat diet-fed ovariectomized mice are susceptible to accelerated subcutaneous tumor growth potentially through adipose tissue inflammation, local insulin-like growth factor release, and tumor associated macrophages Research Paper

Correction: Growth differentiation factor 15 mediates epithelial mesenchymal transition and invasion of breast cancers through IGF-1R-FoxM1 signaling Correction

Important players in carcinogenesis as potential targets in cancer therapy: an update Review

IGF-1 and hyperglycaemia-induced FOXA1 and IGFBP-2 affect epithelial to mesenchymal transition in prostate epithelial cells Research Paper

Tumor suppressor p53 regulates insulin receptor (INSR) gene expression via direct binding to the INSR promoter Research Paper

BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer Research Paper

Protein phosphatase 1 regulatory subunit 1A regulates cell cycle progression in Ewing sarcoma Research Paper

Proteomic analysis of combined IGF1 receptor targeted therapy and chemotherapy identifies signatures associated with survival in breast cancer patients Research Paper

A phase II randomized clinical trial using aglycone isoflavones to treat patients with localized prostate cancer in the pre-surgical period prior to radical prostatectomy Research Paper

Correction: Wogonoside prevents colitis-associated colorectal carcinogenesis and colon cancer progression in inflammation-related microenvironment via inhibiting NF-κB activation through PI3K/Akt pathway Correction

Esophageal 3D organoids of MPV17-/- mouse model of mitochondrial DNA depletion show epithelial cell plasticity and telomere attrition Research Paper

Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells Research Paper

Vascular endothelium function among male carriers of BRCA 1&2 germline mutation Research Paper

Identification of ZYG11A as a candidate IGF1-dependent proto-oncogene in endometrial cancer Research Paper

Correction: Glucocorticoid impairs cell-cell communication by autophagy-mediated degradation of connexin 43 in osteocytes Correction

Comparing progression molecular mechanisms between lung adenocarcinoma and lung squamous cell carcinoma based on genetic and epigenetic networks: big data mining and genome-wide systems identification Research Paper

Comparing progression molecular mechanisms between lung adenocarcinoma and lung squamous cell carcinoma based on genetic and epigenetic networks: big data mining and genome-wide systems identification Research Paper

Distinct mechanisms by which two forms of miR-140 suppress the malignant properties of lung cancer cells Research Paper

Genome-wide association analysis identifies SNPs predictive of in vitro leukemic cell sensitivity to cytarabine in pediatric AML Research Paper

Esophageal 3D organoids of MPV17^-/- mouse model of mitochondrial DNA depletion show epithelial cell plasticity and telomere attrition Research Paper