The Oncosearch | Oncotarget

Epigenetic dysregulation and biological function of PDX1 in prostate cancer Research Paper

Tayo A. Adeyika, Anju Datturgi, Yehnara Ettinoffe, Somiranjan Ghosh, Christopher Albanese, Bernard Kwabi-Addo

Published Apr 1, 2026 · Vol. 17, No. 1 · pp. 157-172

Keywords: PDX1, DNA methylation prostate cancer, shRNA knockdown, over-expression, glucose

Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms Review

Shreya Shyamsunder, Zhixin Lu, Vinita Takiar, Susan E. Waltz

Published Jun 16, 2025 · Vol. 16, No. 1 · pp. 508-530

Keywords: EGFR, RTKs, breast cancer, head and neck cancer, resistance mechanisms

Correction: Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2 Correction

Yan Luo, Lei Liu, Yang Wu, Karnika Singh, Bing Su, Nan Zhang, Xiaowei Liu, Yangmei Shen, Shile Huang

Published Jun 10, 2025 · Vol. 16, No. 1 · pp. 425-426

Retraction: Down-regulation of microRNA-320 suppresses cardiomyocyte apoptosis and protects against myocardial ischemia and reperfusion injury by targeting IGF-1 Retraction

Chun-Li Song, Bin Liu, Hong-Ying Diao, Yong-Feng Shi, Ji-Chang Zhang, Yang-Xue Li, Ning Liu, Yun-Peng Yu, Guan Wang, Jin-Peng Wang, Qian Li

Published Mar 13, 2025 · Vol. 16, No. 1 · pp. 167-167

Retraction: IGF-1 induces the epithelial-mesenchymal transition via Stat5 in hepatocellular carcinoma Retraction

Chuanzong Zhao, Qian Wang, Ben Wang, Qi Sun, Zhaobin He, Jianguo Hong, Florian Kuehn, Enyu Liu, Zongli Zhang

Published Mar 27, 2024 · Vol. 15, No. 1 · pp. 549-549

Transcriptomic analysis identifies four novel receptors potentially linking endometrial cancer with polycystic ovary syndrome and generates a transcriptomic atlas Research Paper

Fatma Alqutami, Mahmood Hachim, Charlie Hodgman, William Atiomo

Published Sep 17, 2023 · Vol. 14, No. 1 · pp. 825-835

Keywords: polycystic ovary syndrome, endometrial cancer, transcriptomics, IGF1, in-silico

Retraction: The crucial role of SRPK1 in IGF-1-induced EMT of human gastric cancer Retraction

Hong Wang, Chunlei Wang, Wenling Tian, Yanfen Yao

Published May 10, 2023 · Vol. 15, No. 1 · pp. 573-573

Correction: IGF-1R, a target of let-7b, mediates crosstalk between IRS-2/Akt and MAPK pathways to promote proliferation of oral squamous cell carcinoma Correction

Ling Gao, Xiaolong Wang, Xiaofei Wang, Linmei Zhang, Cui Qiang, Su’e Chang, Wenhao Ren, Shaoming Li, Yang Yang, Dongdong Tong, Cheng Chen, Zongfang Li, Tusheng Song, Keqian Zhi, Chen Huang

Published Mar 31, 2023

Correction: miR-29a-3p suppresses cell proliferation and migration by downregulating IGF1R in hepatocellular carcinoma Correction

Xiao Wang, Shasha Liu, Ling Cao, Tengfei Zhang, Dongli Yue, Liping Wang, Yu Ping, Qianyi He, Chaoqi Zhang, Meng Wang, Xinfeng Chen, Qun Gao, Dan Wang, Zhen Zhang, Fei Wang, Li Yang, Jieyao Li, Lan Huang, Bin Zhang, Yi Zhang

Published Mar 27, 2023 · Vol. 14, No. 1 · pp. 464-465

Correction: IGF-1 and hyperglycaemia-induced FOXA1 and IGFBP-2 affect epithelial to mesenchymal transition in prostate epithelial cells Correction

Rehanna Mansor, Jeff Holly, Rachel Barker, Kalina Biernacka, Hanna Zielinska, Anthony Koupparis, Edward Rowe, Jon Oxley, Alex Sewell, Richard M. Martin, Athene Lane, Lucy Hackshaw-McGeagh, Claire Perks

Published Jan 7, 2023 · Vol. 14, No. 1 · pp. 44-46

Retraction: Down-regulation of microRNA-320 suppresses cardiomyocyte apoptosis and protects against myocardial ischemia and reperfusion injury by targeting IGF-1 Retraction

Chun-Li Song, Bin Liu, Hong-Ying Diao, Yong-Feng Shi, Ji-Chang Zhang, Yang-Xue Li, Ning Liu, Yun-Peng Yu, Guan Wang, Jin-Peng Wang, Qian Li

Published Dec 14, 2022

Myeloid-derived suppressor cells: Cancer, autoimmune diseases, and more Review

Masahiko Shibata, Kotaro Nanno, Daigo Yoshimori, Takahiro Nakajima, Makoto Takada, Takashi Yazawa, Kousaku Mimura, Norio Inoue, Takafumi Watanabe, Kazunoshin Tachibana, Satoshi Muto, Tomoyuki Momma, Yoshiyuki Suzuki, Koji Kono, Shungo Endo, Seiichi Takenoshita

Published Oct 25, 2022 · Vol. 13, No. 1 · pp. 1273-1285

Keywords: MDSC, immunosuppression, Treg, TAM, cancer

Early-onset pancreatic cancer: a review of molecular mechanisms, management, and survival Review

Mark B. Ulanja, Alastair E. Moody, Bryce D. Beutler, Daniel Antwi-Amoabeng, Ganiyu A. Rahman, Olatunji B. Alese

Published Jun 4, 2022 · Vol. 13, No. 1 · pp. 828-841

Keywords: pancreatic cancer, gastrointestinal malignancy, epidemiology, pancreatic adenocarcinoma

Correlation of nuclear pIGF-1R/IGF-1R and YAP/TAZ in a tissue microarray with outcomes in osteosarcoma patients Research Paper

Eric R. Molina, Letitia K. Chim, Salah-Eddine Lamhamedi-Cherradi, Sana Mohiuddin, David McCall, Branko Cuglievan, Sandhya Krishnan, Robert W. Porter, Davis R. Ingram, Wei-Lien Wang, Alexander J. Lazar, David W. Scott, Danh D. Truong, Najat C. Daw, Joseph A. Ludwig, Antonios G. Mikos

Published Mar 1, 2022 · Vol. 13, No. 1 · pp. 521-533

Keywords: osteosarcoma, YAP/TAZ, IGF-1R, nuclear IGF-1R, mechanotransduction

The role of IGF-pathway biomarkers in determining risks, screening, and prognosis in lung cancer Review

Alexander W. Pohlman, Hita Moudgalya, Lia Jordano, Gabriela C. Lobato, David Gerard, Michael J. Liptay, Christopher W. Seder, Jeffrey A. Borgia

Published Feb 15, 2022 · Vol. 13, No. 1 · pp. 393-407

Keywords: IGF, lung cancer, biomarkers, screening, prognostication

Correction: HRD1 suppresses the growth and metastasis of breast cancer cells by promoting IGF-1R degradation Correction

Yue-Mei Xu, Hong-Jiang Wang, Fang Chen, Wan-Hua Guo, Yan-Yang Wang, Hang-Yu Li, Jin-Hai Tang, Ying Ding, Ya-Chen Shen, Min Li, Wen-Ying Xuan, Lin-Hui Liu, Jia Wang, Xue-Rong Wang, Ze-Jun Gao, Xiu-Bin Liang, Dong-Ming Su

Published Jan 25, 2022

MiR-7-5p inhibits thyroid cell proliferation by targeting the EGFR/MAPK and IRS2/PI3K signaling pathways Research Paper

Alice Augenlicht, Manuel Saiselet, Myriam Decaussin-Petrucci, Guy Andry, Jacques E. Dumont, Carine Maenhaut

Published Jul 17, 2021 · Vol. 12, No. 16 · pp. 1587-1599

Keywords: miRNA, papillary thyroid carcinoma, IRS2, MAPK, PI3K

Multifaceted effect of chlorpromazine in cancer: implications for cancer treatment Review

Pareesa Kamgar-Dayhoff, Tinatin I. Brelidze

Published Jun 19, 2021 · Vol. 12, No. 14 · pp. 1406-1426

Keywords: chlorpromazine, repurposing

Insulin-like growth factor 1/Child-Turcotte-Pugh composite score as a predictor of treatment outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib Research Paper

Yehia I. Mohamed, Sunyoung Lee, Lianchun Xiao, Manal M. Hassan, Aliya Qayyum, Rikita Hiatia, Roberto Carmagnani Pestana, Abedul Haque, Bhawana George, Asif Rashid, Dan G. Duda, Hesham Elghazaly, Robert A. Wolff, Jeffrey S. Morris, James Yao, Hesham M. Amin, Ahmed O. Kaseb

Published Mar 13, 2021 · Vol. 12, No. 8 · pp. 756-766

Keywords: IGF-1, Child-Pugh, sorafenib, liver reserve, hepatocellular carcinoma

Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry Research Paper

Juan Pablo Cerapio, Agnès Marchio, Luis Cano, Ignacio López, Jean-Jacques Fournié, Béatrice Régnault, Sandro Casavilca-Zambrano, Eloy Ruiz, Anne Dejean, Stéphane Bertani, Pascal Pineau

Published Feb 3, 2021 · Vol. 12, No. 5 · pp. 475-492

Keywords: hepatitis B virus, indigenous people, integrative genomics, liver cancer

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Epigenetic dysregulation and biological function of PDX1 in prostate cancer Research Paper

Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms Review

Correction: Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2 Correction

Retraction: Down-regulation of microRNA-320 suppresses cardiomyocyte apoptosis and protects against myocardial ischemia and reperfusion injury by targeting IGF-1 Retraction

Retraction: IGF-1 induces the epithelial-mesenchymal transition via Stat5 in hepatocellular carcinoma Retraction

Transcriptomic analysis identifies four novel receptors potentially linking endometrial cancer with polycystic ovary syndrome and generates a transcriptomic atlas Research Paper

Retraction: The crucial role of SRPK1 in IGF-1-induced EMT of human gastric cancer Retraction

Correction: IGF-1R, a target of let-7b, mediates crosstalk between IRS-2/Akt and MAPK pathways to promote proliferation of oral squamous cell carcinoma Correction

Correction: miR-29a-3p suppresses cell proliferation and migration by downregulating IGF1R in hepatocellular carcinoma Correction

Correction: IGF-1 and hyperglycaemia-induced FOXA1 and IGFBP-2 affect epithelial to mesenchymal transition in prostate epithelial cells Correction

Retraction: Down-regulation of microRNA-320 suppresses cardiomyocyte apoptosis and protects against myocardial ischemia and reperfusion injury by targeting IGF-1 Retraction

Myeloid-derived suppressor cells: Cancer, autoimmune diseases, and more Review

Early-onset pancreatic cancer: a review of molecular mechanisms, management, and survival Review

Correlation of nuclear pIGF-1R/IGF-1R and YAP/TAZ in a tissue microarray with outcomes in osteosarcoma patients Research Paper

The role of IGF-pathway biomarkers in determining risks, screening, and prognosis in lung cancer Review

Correction: HRD1 suppresses the growth and metastasis of breast cancer cells by promoting IGF-1R degradation Correction

MiR-7-5p inhibits thyroid cell proliferation by targeting the EGFR/MAPK and IRS2/PI3K signaling pathways Research Paper

Multifaceted effect of chlorpromazine in cancer: implications for cancer treatment Review

Insulin-like growth factor 1/Child-Turcotte-Pugh composite score as a predictor of treatment outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib Research Paper

Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Epigenetic dysregulation and biological function of PDX1 in prostate cancer Research Paper

Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms Review

Correction: Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2 Correction

Retraction: Down-regulation of microRNA-320 suppresses cardiomyocyte apoptosis and protects against myocardial ischemia and reperfusion injury by targeting IGF-1 Retraction

Retraction: IGF-1 induces the epithelial-mesenchymal transition via Stat5 in hepatocellular carcinoma Retraction

Transcriptomic analysis identifies four novel receptors potentially linking endometrial cancer with polycystic ovary syndrome and generates a transcriptomic atlas Research Paper

Retraction: The crucial role of SRPK1 in IGF-1-induced EMT of human gastric cancer Retraction

Correction: IGF-1R, a target of let-7b, mediates crosstalk between IRS-2/Akt and MAPK pathways to promote proliferation of oral squamous cell carcinoma Correction

Correction: miR-29a-3p suppresses cell proliferation and migration by downregulating IGF1R in hepatocellular carcinoma Correction

Correction: IGF-1 and hyperglycaemia-induced FOXA1 and IGFBP-2 affect epithelial to mesenchymal transition in prostate epithelial cells Correction

Retraction: Down-regulation of microRNA-320 suppresses cardiomyocyte apoptosis and protects against myocardial ischemia and reperfusion injury by targeting IGF-1 Retraction

Myeloid-derived suppressor cells: Cancer, autoimmune diseases, and more Review

Early-onset pancreatic cancer: a review of molecular mechanisms, management, and survival Review

Correlation of nuclear pIGF-1R/IGF-1R and YAP/TAZ in a tissue microarray with outcomes in osteosarcoma patients Research Paper

The role of IGF-pathway biomarkers in determining risks, screening, and prognosis in lung cancer Review

Correction: HRD1 suppresses the growth and metastasis of breast cancer cells by promoting IGF-1R degradation Correction

MiR-7-5p inhibits thyroid cell proliferation by targeting the EGFR/MAPK and IRS2/PI3K signaling pathways Research Paper

Multifaceted effect of chlorpromazine in cancer: implications for cancer treatment Review

Insulin-like growth factor 1/Child-Turcotte-Pugh composite score as a predictor of treatment outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib Research Paper

Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry Research Paper