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MEK inhibition is a promising therapeutic strategy for MLL-rearranged infant acute lymphoblastic leukemia patients carrying RAS mutations Research Paper

Mark Kerstjens, Emma M.C. Driessen, Merel Willekes, Sandra S. PinhanÃ§os, Pauline Schneider, Rob Pieters, Ronald W. Stam

Published Aug 31, 2016 · Vol. 8, No. 9 · pp. 14835-14846

Targeting hexokinase 2 enhances response to radio-chemotherapy in glioblastoma Research Paper

Alenoush Vartanian, Sameer Agnihotri, Mark R. Wilson, Kelly E. Burrell, Peter D. Tonge, Amir Alamsahebpour, Shahrzad Jalali, Michael S. Taccone, Sheila Mansouri, Brian Golbourn, Kenneth D. Aldape, Gelareh Zadeh

Published Aug 29, 2016 · Vol. 7, No. 43 · pp. 69518-69535

PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2Î± phosphorylation in established cell lines and primary human leukemia cells Research Paper

Alison Yeomans, Elizabeth Lemm, Sarah Wilmore, Breeze E. Cavell, Beatriz Valle-Argos, Sergey Krysov, Marina Sanchez Hidalgo, Elodie Leonard, Anne E. Willis, Francesco Forconi, Freda K. Stevenson, Andrew J. Steele, Mark J. Coldwell, Graham Packham

Published Aug 27, 2016 · Vol. 7, No. 46 · pp. 74807-74819

[¹¹C]Choline PET/CT in therapy response assessment of a neoadjuvant therapy in locally advanced and high risk prostate cancer before radical prostatectomy Research Paper

Sarah M. SchwarzenbÃ¶ck, Anna Knieling, Michael Souvatzoglou, Jens Kurth, Katja Steiger, Matthias Eiber, Irene Esposito, Margitta Retz, Hubert KÃ¼bler, JÃ¼rgen E. Gschwend, Markus Schwaiger, Bernd J. Krause, Mark Thalgott

Published Aug 27, 2016 · Vol. 7, No. 39 · pp. 63747-63757

A polycomb-mediated epigenetic field defect precedes invasive cervical carcinoma Research Paper

Neil Ari Wijetunga, Miriam Ben-Dayan, Jessica Tozour, Robert D. Burk, Nicolas F. Schlecht, Mark H. Einstein, John M. Greally

Published Aug 19, 2016 · Vol. 7, No. 38 · pp. 62133-62143

Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2Î± kinase in cortical neurons Research Paper

Eva Ramos-FernÃ¡ndez, Marta Tajes, Gerard ILL-Raga, Lina Vargas, Arnau Busquets-GarcÃa, MÃ²nica Bosch-MoratÃ³, Biuse Guivernau, VictÃ²ria Valls-Comamala, Maria Gomis, Cristina Grau, CÃ©sar Fandos, Mark D. Rosen, Michael H. Rabinowitz, Nibaldo Inestrosa, Rafael Maldonado, Xavier Altafaj, AndrÃ©s Ozaita, Alejandra Alvarez, RubÃ©n Vicente, Miguel A. Valverde, Francisco J. MuÃ±oz

Published Aug 19, 2016 · Vol. 7, No. 37 · pp. 58876-58892

Phase II trial of concurrent chemoradiotherapy with L-asparaginase and MIDLE chemotherapy for newly diagnosed stage I/II extranodal NK/T-cell lymphoma, nasal type (CISL-1008) Clinical Research Papers

Dok Hyun Yoon, Seok Jin Kim, Seong Hyun Jeong, Dong-Yeop Shin, Sung Hwa Bae, Junshik Hong, Seong Kyu Park, Ho-Young Yhim, Deok-Hwan Yang, Hyewon Lee, Hye Jin Kang, Mark Hong Lee, Hyeon-Seok Eom, Jae-Yong Kwak, Jae Hoon Lee, Cheolwon Suh, Won Seog Kim

Published Aug 16, 2016 · Vol. 7, No. 51 · pp. 85584-85591

Immortalization of human AE pre-leukemia cells by hTERT allows leukemic transformation Priority Research Paper

Shan Lin, Junping Wei, Mark Wunderlich, Fu-Sheng Chou, James C. Mulloy

Published Aug 5, 2016 · Vol. 7, No. 35 · pp. 55939-55950

EGFR-targeted therapy results in dramatic early lung tumor regression accompanied by imaging response and immune infiltration in EGFR mutant transgenic mouse models Priority Research Paper

Abhilash Venugopalan, Min-Jung Lee, Gang Niu, JosÃ© Medina-Echeverz, Yusuke Tomita, Martin J. Lizak, Constance M. Cultraro, Robert Mark Simpson, Xiaoyuan Chen, Jane B. Trepel, Udayan Guha

Published Aug 2, 2016 · Vol. 7, No. 34 · pp. 54137-54156

Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21 Priority Research Paper

Mingfeng Zhang, Zhaoming Wang, Ofure Obazee, Jinping Jia, Erica J. Childs, Jason Hoskins, Gisella Figlioli, Evelina Mocci, Irene Collins, Charles C. Chung, Christopher Hautman, Alan A. Arslan, Laura Beane-Freeman, Paige M. Bracci, Julie Buring, Eric J. Duell, Steven Gallinger, Graham G. Giles, Gary E. Goodman, Phyllis J. Goodman, Aruna Kamineni, Laurence N. Kolonel, Matthew H. Kulke, NÃºria Malats, Sara H. Olson, Howard D. Sesso, Kala Visvanathan, Emily White, Wei Zheng, Christian C. Abnet, Demetrius Albanes, Gabriella Andreotti, Lauren Brais, H. Bas Bueno-de-Mesquita, Daniela Basso, Sonja I. Berndt, Marie-Christine Boutron-Ruault, Maarten F. Bijlsma, Hermann Brenner, Laurie Burdette, Daniele Campa, Neil E. Caporaso, Gabriele Capurso, Giulia Martina Cavestro, Michelle Cotterchio, Eithne Costello, Joanne Elena, Ugo Boggi, J. Michael Gaziano, Maria Gazouli, Edward L. Giovannucci, Michael Goggins, Myron Gross, Christopher A. Haiman, Manal Hassan, Kathy J. Helzlsouer, Nan Hu, David J. Hunter, Elzbieta Iskierka-Jazdzewska, Mazda Jenab, Rudolf Kaaks, Timothy J. Key, Kay-Tee Khaw, Eric A. Klein, Manolis Kogevinas, Vittorio Krogh, Juozas Kupcinskas, Robert C. Kurtz, Maria T. Landi, Stefano Landi, Loic Le Marchand, Andrea Mambrini, Satu Mannisto, Roger L. Milne, Rachel E. Neale, Ann L. Oberg, Salvatore Panico, Alpa V. Patel, Petra H. M. Peeters, Ulrike Peters, Raffaele Pezzilli, Miquel Porta, Mark Purdue, J. RamÃ³n Quiros, Elio Riboli, Nathaniel Rothman, Aldo Scarpa, Ghislaine Scelo, Xiao-Ou Shu, Debra T. Silverman, Pavel Soucek, Oliver Strobel, Malin Sund, Ewa MaÅ‚ecka-Panas, Philip R. Taylor, Francesca Tavano, Ruth C. Travis, Mark Thornquist, Anne Tjønneland, Geoffrey S. Tobias, Dimitrios Trichopoulos, Yogesh Vashist, Pavel Vodicka, Jean Wactawski-Wende, Nicolas Wentzensen, Herbert Yu, Anne Zeleniuch-Jacquotte, Charles Kooperberg, Harvey A. Risch, Eric J. Jacobs, Donghui Li, Charles Fuchs, Robert Hoover, Patricia Hartge, Stephen J. Chanock, Gloria M. Petersen, Rachael S. Stolzenberg-Solomon, Brian M. Wolpin, Peter Kraft, Alison P. Klein, Federico Canzian, Laufey T. Amundadottir

Published Aug 1, 2016 · Vol. 7, No. 41 · pp. 66328-66343

Ubc13: the Lys63 ubiquitin chain building machine Review

Curtis D. Hodge, Leo Spyracopoulos, J. N. Mark Glove

Published Jul 29, 2016 · Vol. 7, No. 39 · pp. 64471-64504

Samarium-153-EDTMP (Quadramet^Â®) with or without vaccine in metastatic castration-resistant prostate cancer: A randomized Phase 2 trial Clinical Research Papers

Christopher R. Heery, Ravi A. Madan, Mark N. Stein, Walter M. Stadler, Robert S. DiPaola, Myrna Rauckhorst, Seth M. Steinberg, Jennifer L. MartÃ©, Clara C. Chen, Italia Grenga, Renee N. Donahue, Caroline Jochems, William L. Dahut, Jeffrey Schlom, James L. Gulley

Published Jul 28, 2016 · Vol. 7, No. 42 · pp. 69014-69023

Targeting of the MAPK and AKT pathways in conjunctival melanoma shows potential synergy Research Paper

Jinfeng Cao, Renier C. Heijkants, Aart G. Jochemsen, Mehmet DogrusÃ¶z, Mark J. de Lange, Pieter A. van der Velden, Sjoerd H. van der Burg, Martine J. Jager, Robert M. Verdijk

Published Jul 22, 2016 · Vol. 8, No. 35 · pp. 58021-58036

The pancreatic tumor microenvironment drives changes in miRNA expression that promote cytokine production and inhibit migration by the tumor associated stroma Research Paper

Song Han, David H. Gonzalo, Michael Feely, Daniel Delitto, Kevin E. Behrns, Mark Beveridge, DongYu Zhang, Ryan Thomas, Jose G. Trevino, Thomas D. Schmittgen, Steven J. Hughes

Published Jul 20, 2016 · Vol. 8, No. 33 · pp. 54054-54067

Transcriptome-wide identification of mRNAs and lincRNAs associated with trastuzumab-resistance in HER2-positive breast cancer Research Paper

Callie R. Merry, Sarah McMahon, Megan E. Forrest, Cynthia F. Bartels, Alina Saiakhova, Courtney A. Bartel, Peter C. Scacheri, Cheryl L. Thompson, Mark W. Jackson, Lyndsay N. Harris, Ahmad M. Khalil

Published Jul 16, 2016 · Vol. 7, No. 33 · pp. 53230-53244

HER2-HER3 dimer quantification by FLIM-FRET predicts breast cancer metastatic relapse independently of HER2 IHC status Research Paper

Gregory Weitsman, Paul R. Barber, Lan K. Nguyen, Katherine Lawler, Gargi Patel, Natalie Woodman, Muireann T. Kelleher, Sarah E. Pinder, Mark Rowley, Paul A. Ellis, Anand D. Purushotham, Anthonius C. Coolen, Boris N. Kholodenko, Borivoj Vojnovic, Cheryl Gillett, Tony Ng

Published Jul 7, 2016 · Vol. 7, No. 32 · pp. 51012-51026

A novel isoflavone, ME-344, targets the cytoskeleton in acute myeloid leukemia Research Paper

Danny V. Jeyaraju, Rose Hurren, Xiaoming Wang, Neil MacLean, Marcela Gronda, Aisha Shamas-Din, Mark D. Minden, Guri Giaever, Aaron D. Schimmer

Published Jul 6, 2016 · Vol. 7, No. 31 · pp. 49777-49785

Î²-cell insulin receptor deficiency during in utero development induces an islet compensatory overgrowth response Research Paper

Mark Trinder, Liangyi Zhou, Amanda Oakie, Matthew Riopel, Rennian Wang

Published Jun 30, 2016 · Vol. 7, No. 29 · pp. 44927-44940

Lin28B promotes MÃ¼ller glial cell de-differentiation and proliferation in the regenerative rat retinas Research Paper

Zui Tao, Chen Zhao, Qian Jian, Mark Gillies, Haiwei Xu, Zheng Qin Yin

Published Jun 30, 2016 · Vol. 7, No. 31 · pp. 49368-49383

Obesity does not promote tumorigenesis of localized patient-derived prostate cancer xenografts Research Paper

Jennifer C.Y. Lo, Ashlee K. Clark, Natasha Ascui, Mark Frydenberg, Gail P. Risbridger, Renea A. Taylor, Matthew J. Watt

Published Jun 23, 2016 · Vol. 7, No. 30 · pp. 47650-47662

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MEK inhibition is a promising therapeutic strategy for MLL-rearranged infant acute lymphoblastic leukemia patients carrying RAS mutations Research Paper

Targeting hexokinase 2 enhances response to radio-chemotherapy in glioblastoma Research Paper

PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2Î± phosphorylation in established cell lines and primary human leukemia cells Research Paper

[¹¹C]Choline PET/CT in therapy response assessment of a neoadjuvant therapy in locally advanced and high risk prostate cancer before radical prostatectomy Research Paper

A polycomb-mediated epigenetic field defect precedes invasive cervical carcinoma Research Paper

Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2Î± kinase in cortical neurons Research Paper

Phase II trial of concurrent chemoradiotherapy with L-asparaginase and MIDLE chemotherapy for newly diagnosed stage I/II extranodal NK/T-cell lymphoma, nasal type (CISL-1008) Clinical Research Papers

Immortalization of human AE pre-leukemia cells by hTERT allows leukemic transformation Priority Research Paper

EGFR-targeted therapy results in dramatic early lung tumor regression accompanied by imaging response and immune infiltration in EGFR mutant transgenic mouse models Priority Research Paper

Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21 Priority Research Paper

Ubc13: the Lys63 ubiquitin chain building machine Review

Samarium-153-EDTMP (Quadramet^Â®) with or without vaccine in metastatic castration-resistant prostate cancer: A randomized Phase 2 trial Clinical Research Papers

Targeting of the MAPK and AKT pathways in conjunctival melanoma shows potential synergy Research Paper

The pancreatic tumor microenvironment drives changes in miRNA expression that promote cytokine production and inhibit migration by the tumor associated stroma Research Paper

Transcriptome-wide identification of mRNAs and lincRNAs associated with trastuzumab-resistance in HER2-positive breast cancer Research Paper

HER2-HER3 dimer quantification by FLIM-FRET predicts breast cancer metastatic relapse independently of HER2 IHC status Research Paper

A novel isoflavone, ME-344, targets the cytoskeleton in acute myeloid leukemia Research Paper

Î²-cell insulin receptor deficiency during in utero development induces an islet compensatory overgrowth response Research Paper

Lin28B promotes MÃ¼ller glial cell de-differentiation and proliferation in the regenerative rat retinas Research Paper

Obesity does not promote tumorigenesis of localized patient-derived prostate cancer xenografts Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

MEK inhibition is a promising therapeutic strategy for MLL-rearranged infant acute lymphoblastic leukemia patients carrying RAS mutations Research Paper

Targeting hexokinase 2 enhances response to radio-chemotherapy in glioblastoma Research Paper

PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2Î± phosphorylation in established cell lines and primary human leukemia cells Research Paper

[11C]Choline PET/CT in therapy response assessment of a neoadjuvant therapy in locally advanced and high risk prostate cancer before radical prostatectomy Research Paper

A polycomb-mediated epigenetic field defect precedes invasive cervical carcinoma Research Paper

Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2Î± kinase in cortical neurons Research Paper

Phase II trial of concurrent chemoradiotherapy with L-asparaginase and MIDLE chemotherapy for newly diagnosed stage I/II extranodal NK/T-cell lymphoma, nasal type (CISL-1008) Clinical Research Papers

Immortalization of human AE pre-leukemia cells by hTERT allows leukemic transformation Priority Research Paper

EGFR-targeted therapy results in dramatic early lung tumor regression accompanied by imaging response and immune infiltration in EGFR mutant transgenic mouse models Priority Research Paper

Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21 Priority Research Paper

Ubc13: the Lys63 ubiquitin chain building machine Review

Samarium-153-EDTMP (QuadrametÂ®) with or without vaccine in metastatic castration-resistant prostate cancer: A randomized Phase 2 trial Clinical Research Papers

Targeting of the MAPK and AKT pathways in conjunctival melanoma shows potential synergy Research Paper

The pancreatic tumor microenvironment drives changes in miRNA expression that promote cytokine production and inhibit migration by the tumor associated stroma Research Paper

Transcriptome-wide identification of mRNAs and lincRNAs associated with trastuzumab-resistance in HER2-positive breast cancer Research Paper

HER2-HER3 dimer quantification by FLIM-FRET predicts breast cancer metastatic relapse independently of HER2 IHC status Research Paper

A novel isoflavone, ME-344, targets the cytoskeleton in acute myeloid leukemia Research Paper

Î²-cell insulin receptor deficiency during in utero development induces an islet compensatory overgrowth response Research Paper

Lin28B promotes MÃ¼ller glial cell de-differentiation and proliferation in the regenerative rat retinas Research Paper

Obesity does not promote tumorigenesis of localized patient-derived prostate cancer xenografts Research Paper

[¹¹C]Choline PET/CT in therapy response assessment of a neoadjuvant therapy in locally advanced and high risk prostate cancer before radical prostatectomy Research Paper

Samarium-153-EDTMP (Quadramet^Â®) with or without vaccine in metastatic castration-resistant prostate cancer: A randomized Phase 2 trial Clinical Research Papers