Inhibition of astrocytic activity alleviates sequela in acute stages of intracerebral hemorrhage

Cheng-Di Chiu; Nai-Wei Yao; Jeng-Hung Guo; Chiung-Chyi Shen; Hsu-Tung Lee; You-Pen Chiu; Hui-Ru Ji; Xianxiu Chen; Chun-Chung Chen; Chen Chang

doi:10.18632/oncotarget.22022

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Inhibition of astrocytic activity alleviates sequela in acute stages of intracerebral hemorrhage

Cheng-Di Chiu _, Nai-Wei Yao, Jeng-Hung Guo, Chiung-Chyi Shen, Hsu-Tung Lee, You-Pen Chiu, Hui-Ru Ji, Xianxiu Chen, Chun-Chung Chen and Chen Chang

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2017; 8:94850-94861. https://doi.org/10.18632/oncotarget.22022

Metrics: PDF 1566 views | HTML 2719 views | ?

Abstract

Cheng-Di Chiu1,3,4,5, Nai-Wei Yao1,2,5, Jeng-Hung Guo4, Chiung-Chyi Shen6, Hsu-Tung Lee7, You-Pen Chiu1,5, Hui-Ru Ji3,5, Xianxiu Chen1,4,5, Chun-Chung Chen1,4,5 and Chen Chang2

1School of Medicine, China Medical University, Taichung, Taiwan

2Institute of Biomedical Sciences, Academic Sinica, Taipei, Taiwan

3Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan

4Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan

5Stroke Center, China Medical University Hospital, Taichung, Taiwan

6Department of Minimally Invasive Skull Base Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan

7Department of Neurosurgical Oncology, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan

Correspondence to:

Cheng-Di Chiu, email: [email protected]

Keywords: acute stroke; intracerebral hemorrhage; astrocyte; blood–brain barrier; MRI

Received: August 02, 2017 Accepted: September 22, 2017 Published: October 24, 2017

ABSTRACT

Neurological deterioration of intracerebral hemorrhage (ICH) mostly occurs within the first 24 hours. Together with the microglia/macrophages (MMΦ), astrocytes are important cell population responsible for many brain injuries but rarely being highlighted in acute stage of ICH. In present study, we induced rats ICH either by collagenase or autologous blood injection. Experimental groups were classified as vehicle or Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (Pyr3) treatment group (n = 9, each group). MRI assessments after ICH were used to evaluate the hematoma progression and blood–brain barrier (BBB) integrity. The glia cells accumulations were examined by GFAP and Iba1 immunohistochemistry, respectively. Abundant astrocytes but few MMΦ were observed in hyperacute and acute ICH. Upon suppression of astrocyte activity, ICH rats exhibited decreased size of hematoma expansion, less BBB destruction, reduced astrocyte accumulation in perihematomal regions, postponed course of hemoresolution and gain better outcomes. These finding provide evidence that activated astrocytes are crucial cell populations in hyperacute and acute ICH, and their modulation may offer opportunities for novel therapy and patient management.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 22022

Publication Alerts

Research Papers:

Inhibition of astrocytic activity alleviates sequela in acute stages of intracerebral hemorrhage

Abstract