Research Papers:

Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma: A pilot study

Tia Morosin, Bruce Ashford _, Marie Ranson, Ruta Gupta, Jonathan Clark, N. Gopalakrishna Iyer and Kevin Spring

PDF  |  HTML  |  How to cite

Oncotarget. 2016; 7:47111-47115. https://doi.org/10.18632/oncotarget.9946

Metrics: PDF 1301 views  |   HTML 2239 views  |   ?  


Tia Morosin1, Bruce Ashford2,3,4,5, Marie Ranson2,3,5, Ruta Gupta6,7, Jonathan Clark8,9,10,11, N. Gopalakrishna Iyer12, Kevin Spring5,10,13

1Graduate School of Medicine, University of Wollongong, Wollongong, NSW 2522, Australia

2School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia

3Illawarra Health and Medical Research Institute (IHMRI), Wollongong, NSW 2522, Australia

4Illawarra and Shoalhaven Local Health District (ISLHD), Wollongong, NSW 2522, Australia

5Centre for Oncology Education and Research Translation (CONCERT), Liverpool, NSW 2170, Australia

6Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia

7The University of Sydney, Sydney, NSW 2006, Australia

8Sydney Head and Neck Cancer Institute, Department of Head and Neck Surgery, The Chris O'Brien Lifehouse, Camperdown, NSW 2050, Australia

9Central Clinical School, The University of Sydney, Sydney, NSW 2006, Australia

10South West Clinical School, Faculty of Medicine, The University of New South Wales, Sydney, NSW 2052, Australia

11Singhealth/Duke-NUS Head and Neck Center, National Cancer Center Singapore (NCCS), 169610, Singapore

12Medical Oncology Group, Ingham Institute for Applied Medical Research, Liverpool, NSW 2170, Australia

13Liverpool Clinical School, Western Sydney University, Liverpool, NSW 1871, Australia

Correspondence to:

Bruce Ashford, email: [email protected]

Keywords: circulating tumour cells (CTCs), metastases, cutaneous, squamous cell carcinoma (SCC), head and neck

Received: February 25, 2016     Accepted: April 16, 2016     Published: June 11, 2016


Background: Circulating tumour cells (CTCs) are increasingly being used in the surveillance of cancer, allowing for potential early detection and real-time monitoring of disease progression. The presence of CTCs in patients with metastatic cutaneous head and neck squamous cell carcinoma (cHNSCC) has not been evaluated.

Results: CTCs were detected in eight of ten patients with regional metastatic cHNSCC (80%; range 1–44 cells/9 mL blood). CTMs were detected in three of ten patients (30%, range 1–4 cells/9 mL blood).

Methods: Preoperative blood samples from ten patients with nodal metastases from cutaneous squamous cell carcinomas (cSCC) were analyzed using the IsoFluxTM System for the detection and enumeration of CTCs and circulating tumour microemboli (CTMs).

Conclusions: For the first time CTCs have been detected in patients with nodal metastases from cHNSCC. Further work is required to understand their prognostic significance and potential to directly influence clinical practice.

Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 9946