Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma: A pilot study
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Tia Morosin1, Bruce Ashford2,3,4,5, Marie Ranson2,3,5, Ruta Gupta6,7, Jonathan Clark8,9,10,11, N. Gopalakrishna Iyer12, Kevin Spring5,10,13
1Graduate School of Medicine, University of Wollongong, Wollongong, NSW 2522, Australia
2School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia
3Illawarra Health and Medical Research Institute (IHMRI), Wollongong, NSW 2522, Australia
4Illawarra and Shoalhaven Local Health District (ISLHD), Wollongong, NSW 2522, Australia
5Centre for Oncology Education and Research Translation (CONCERT), Liverpool, NSW 2170, Australia
6Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
7The University of Sydney, Sydney, NSW 2006, Australia
8Sydney Head and Neck Cancer Institute, Department of Head and Neck Surgery, The Chris O'Brien Lifehouse, Camperdown, NSW 2050, Australia
9Central Clinical School, The University of Sydney, Sydney, NSW 2006, Australia
10South West Clinical School, Faculty of Medicine, The University of New South Wales, Sydney, NSW 2052, Australia
11Singhealth/Duke-NUS Head and Neck Center, National Cancer Center Singapore (NCCS), 169610, Singapore
12Medical Oncology Group, Ingham Institute for Applied Medical Research, Liverpool, NSW 2170, Australia
13Liverpool Clinical School, Western Sydney University, Liverpool, NSW 1871, Australia
Bruce Ashford, email: [email protected]
Keywords: circulating tumour cells (CTCs), metastases, cutaneous, squamous cell carcinoma (SCC), head and neck
Received: February 25, 2016 Accepted: April 16, 2016 Published: June 11, 2016
Background: Circulating tumour cells (CTCs) are increasingly being used in the surveillance of cancer, allowing for potential early detection and real-time monitoring of disease progression. The presence of CTCs in patients with metastatic cutaneous head and neck squamous cell carcinoma (cHNSCC) has not been evaluated.
Results: CTCs were detected in eight of ten patients with regional metastatic cHNSCC (80%; range 1–44 cells/9 mL blood). CTMs were detected in three of ten patients (30%, range 1–4 cells/9 mL blood).
Methods: Preoperative blood samples from ten patients with nodal metastases from cutaneous squamous cell carcinomas (cSCC) were analyzed using the IsoFluxTM System for the detection and enumeration of CTCs and circulating tumour microemboli (CTMs).
Conclusions: For the first time CTCs have been detected in patients with nodal metastases from cHNSCC. Further work is required to understand their prognostic significance and potential to directly influence clinical practice.
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