Systematic analyses and comprehensive field synopsis of genetic association studies in hepatocellular carcinoma
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Dong Dong1,2,*, Yang Zou1,*, Pan Zhang1, Zhihong Wu2,3
1Laboratory of Molecular Ecology and Evolution, Institute of Estuarine and Coastal Research, East China Normal University, Shanghai, 200062, P.R. China
2Beijing Key Laboratory for Genetic Research of Bone and Joint Disease, Beijing, 100730, P.R. China
3Central laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, P.R. China
*These authors contributed equally to this work
Dong Dong, email: firstname.lastname@example.org
Zhihong Wu, email: email@example.com
Keywords: hepatocellular carcinoma, meta-analyses
Received: March 04, 2016 Accepted: May 23, 2016 Published: June 10, 2016
Hepatocellular carcinoma (HCC) is one of the most common malignancy in the world. In order to comprehensively examine the association between genetic variants and risk of HCC, a systematic literature search and meta-analyses of the evidences have been performed. With the data from 301 articles, we conducted meta-analyses for 69 polymorphisms involving 46 distinct genes. The result showed that 31 polymorphisms in 25 genes are significantly associated with HCC risk. Cumulative epidemiological evidence for a significant association with HCC risk was graded strong for one polymorphism (NQO1 rs1800566). Furthermore, we provided a database to integrate and analyze the association of genetic variants and HCC risk. To the best of our knowledge, this is the first comprehensive field synopsis and systematic meta-analysis of genetic association with HCC risk. We have provided a useful resource and platform for investigators to explore the association of sequence polymorphisms and HCC risk.
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