Prognostic significance of stem cell-related marker expression and its correlation with histologic subtypes in lung adenocarcinoma
Metrics: PDF 691 views | HTML 1237 views | ?
Eunhyang Park1, Soo Young Park2, Ping-Li Sun2,6, Yan Jin2,7, Ji Eun Kim3, Sanghoon Jheon4, Kwhanmien Kim4, Choon Taek Lee5, Hyojin Kim2,*, Jin-Haeng Chung2,*
1Department of Pathology, Seoul National University Hospital, Seoul, Republic of Korea
2Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
3Department of Pathology, Seoul National University Boramae Hospital, Seoul, Republic of Korea
4Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
5Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
6Department of Pathology, Jilin University Second Hospital, Changchun, China
7Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China
*These authors have contributed equally to this work
Hyojin Kim, email: firstname.lastname@example.org
Jin-Haeng Chung, email: email@example.com
Keywords: cancer stem cell marker, immunohistochemistry, lung cancer, adenocarcinoma, Nanog
Received: January 26, 2016 Accepted: May 16, 2016 Published: June 07, 2016
Cancer stem cells (CSCs) are a small subset of tumor cells that exhibit stem cell-like properties and contribute in treatment failure. To clarify the expression and prognostic significance of several CSC markers in non-small cell lung cancer, we retrospectively analyzed 368 patients with adenocarcinoma (n = 226) or squamous cell carcinoma (n = 142). We correlated the expression of six CSC markers – CD133, CD44, aldehyde dehydrogenase 1 (ALDH1), sex determining region Y-box 2 (SOX2), octamer binding transcription factor 4 (OCT4), and Nanog – with clinicopathologic and molecular variables and survival outcomes. In adenocarcinoma, CD133, ALDH1 and CD44 expression was associated with low pathologic stage and absence of lymphovascular invasion, while Nanog expression correlated with high histologic grade, lymphatic invasion and increased expression of Snail-1, a transcription factor associated with epithelial-mesenchymal transition. CSC marker expression was also associated with histologic subtypes in adenocarcinoma. Multivariate analysis showed that high Nanog expression was an independent factor associated with a poor prognosis in adenocarcinoma. CSC markers had no prognostic value in squamous cell carcinoma. These results suggest that Nanog is an independent negative prognostic factor that may be associated with epithelial-mesenchymal transition in lung adenocarcinoma.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.