Research Papers: Immunology:

4,4’-diaponeurosporene, a C30 carotenoid, effectively activates dendritic cells via CD36 and NF-κB signaling in a ROS independent manner

Haofei Liu, Wenwen Xu, Xiaojing Chang, Tao Qin, Yinyan Yin and Qian Yang _

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Oncotarget. 2016; 7:40978-40991. https://doi.org/10.18632/oncotarget.9800

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Haofei Liu1, Wenwen Xu1, Xiaojing Chang1, Tao Qin1, Yinyan Yin1 and Qian Yang1

1 Key Laboratory of Animal Physiology and Biochemistry, Ministry of Agriculture, Nanjing Agricultural University, Nanjing, Jiangsu, People’s Republic of China

Correspondence to:

Qian Yang, email:

Keywords: 4,4’-diaponeurosporene, C30 carotenoids, dendritic cells, CD36, Immunology and Microbiology Section, Immune response, Immunity

Received: January 12, 2016 Accepted: May 28, 2016 Published: June 02, 2016


Carotenoids could be divided into C30 carotenoids and C40 carotenoids. The immune functions of C40 carotenoids had been extensively researched, while those of C30 carotenoids still remain unclear. In this study, the immune functions of a biosynthetic C30 carotenoid, 4,4’-diaponeurosporene (Dia), were identified on dendritic cells (DCs). DCs treated with 1 μM Dia for 24 h showed morphologic and phenotypic characteristics of mature state and had an increased production of IL-6, IL-10, IL-12p70 and TNFα, while β-carotene had a suppressive effect on DCs maturation. Moreover, Dia promoted antigen uptake of DCs in vitro and increased the quantity of antigen loaded DCs in mesenteric lymph nodes (MLN). Dia-treated DCs also had an enhanced ability to stimulate T cell proliferation and Th1 polarization. Further researches showed that Dia activated DCs via CD36 as well as ERK, JNK, and NF-κB signals in a reactive oxygen species (ROS) independent manner.

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