High expression of galectin-7 associates with poor overall survival in patients with non-metastatic clear-cell renal cell carcinoma
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Jieti Wang1,*, Yidong Liu1,*, Yuanfeng Yang2,*, Zhiying Xu1, Guodong Zhang1, Zheng Liu1, Hangcheng Fu1, Zewei Wang1, Haiou Liu3, Jiejie Xu1
1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
2Department of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
3Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200011, China
*These authors contributed equally to this work
Haiou Liu, email: email@example.com
Jiejie Xu, email: firstname.lastname@example.org
Keywords: clear-cell renal cell carcinoma, galectin-7, prognosis, nomogram
Received: April 09, 2016 Accepted: May 23, 2016 Published: May 31, 2016
Background: Galectin-7, has a controversial role in tumor progression, can either suppress tumor growth or induce chemoresistance depends on different tumor histology types. The aim was to appraise Galectin-7 expression on the overall survival (OS) of patients with non-metastatic clear cell renal cell carcinoma (ccRCC) following surgery.
Results: High galectin-7 expression was specifically correlated with necrosis (P = 0.015). Multivariate analysis confirmed galectin-7 as an independent prognosticator for OS (P = 0.005). High galectin-7 expression suggested poor OS (P < 0.001), particularly with UISS intermediate and high score groups. Notably, the predictive accuracy of the traditional prognostic scores was improved when combined with galectin-7 expression.
Materials and Methods: We retrospectively enrolled 416 patients who underwent nephrectomy at a single institute between 2008 and 2009 and detected their intratumor galectin-7 expression by immunohistochemistry. Kaplan-Meier method was conducted to plot survival curves and multivariate cox regression analysis for potential independent prognostic factors on OS. A nomogram was constructed with concordance index (C-index) and Akaike’s Information Criteria (AIC) to appraise prognostic accuracy of different models.
Conclusions: High galectin-7 expression is an independent adverse predictor for survival. Evaluation of galectin-7 could help guide postsurgical management for non-metastatic ccRCC patients.
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