Oncotarget

Research Papers:

Lnc-CC3 increases metastasis in cervical cancer by increasing Slug expression

Binyuan Jiang, Ruili Sun, Shujuan Fang, Changfei Qin, Xi Pan, Li Peng, Yuehui Li and Guancheng Li _

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Oncotarget. 2016; 7:41650-41661. https://doi.org/10.18632/oncotarget.9519

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Abstract

Binyuan Jiang1,2,3, Ruili Sun1,2,3, Shujuan Fang1,2,3, Changfei Qin1,2,3, Xi Pan1,2,3, Li Peng1,2,3, Yuehui Li1,2,3, Guancheng Li1,2,3

1Cancer Research Institute, Central South University, Changsha 410078, China

2Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Changsha 410078, China

3Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410078, China

Correspondence to:

Guancheng Li, email: ligc61@csu.edu.cn

Keywords: cervical cancer, long noncoding RNA (LncRNA), lnc-CC3, tumor metastasis, Slug

Received: September 15, 2015     Accepted: April 25, 2016     Published: May 20, 2016

ABSTRACT

Although screening has reduced mortality rates, metastasis still results in poor survival and prognosis in cervical cancer patients. We compared cervical cancer ESTs libraries with other ESTs libraries to identify candidate genes and cloned a novel cervical cancer-associated lncRNA, lnc-CC3. Overexpression of lnc-CC3 promoted migration and invasion by SiHa cervical cancer cells in vitro and in vivo, increased Slug expression, and reduced the expression of the epithelial cell marker E-cadherin. Conversely, lnc-CC3 knockdown altered SiHa cell morphology and increased the expression of E-cadherin, thereby suppressing migration and invasion. These results suggest lnc-CC3 may be a useful marker of metastasis in cervical cancer.


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