Research Papers:

Clinical and genetic features of lung squamous cell cancer in never-smokers

Yangle Huang, Rui Wang, Yunjian Pan, Yang Zhang, Hang Li, Chao Cheng, Difan Zheng, Shanbo Zheng, Yuan Li, Xuxia Shen, Haichuan Hu, Deng Cai, Shengfei Wang, Yawei Zhang, Jiaqing Xiang, Yihua Sun, Jie Zhang and Haiquan Chen _

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Oncotarget. 2016; 7:35979-35988. https://doi.org/10.18632/oncotarget.8745

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Yangle Huang1,*, Rui Wang2,*, Yunjian Pan1,*, Yang Zhang1, Hang Li1, Chao Cheng1, Difan Zheng1, Shanbo Zheng1, Yuan Li1, Xuxia Shen1, Haichuan Hu1, Deng Cai1, Shengfei Wang1, Yawei Zhang1, Jiaqing Xiang1, Yihua Sun1, Jie Zhang1, Haiquan Chen1

1Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China

2Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China

*These authors contributed equally to this work

Correspondence to:

Jie Zhang, email: [email protected]

Yihua Sun, email: [email protected]

Haiquan Chen, email: [email protected]

Keywords: squamous cell lung cancer, never-smoker, clinicopathological characteristics, genetic features

Received: October 09, 2015     Accepted: March 16, 2016     Published: April 15, 2016


To evaluate the importance of specific driver mutations to the development and outcome of lung squamous cell cancer (SQCC) in never-smokers, we assessed the clinicopathological characteristics and outcomes of 597 patients who underwent complete resection of SQCCs. In total, 88 (14.7%) never-smokers and 509 (85.3%) ever-smokers were compared. The never-smokers included more females (42.05% vs. 1.57%, P < 0.001) and more often had a personal history of malignant disease (9.09% vs. 2.36%, P = 0.003). The tumors of never-smokers were more often poorly differentiated (70.45% vs. 53.24%, P = 0.010) and more often contained oncogenic mutations (21.05% vs 11.05%, P = 0.023), particularly EGFR mutations (13.16% vs 3.40%, P = 0.001). Never-smokers also tended to have poorer OS than smokers. Our results suggest lung SQCCs in never-smokers are a subtype distinct from SQCCs occurring in smokers.

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