Oncotarget

Research Papers:

This article has been corrected. Correction in: Oncotarget. 2022; 13:118-119.

Prediction of survival prognosis of non-small cell lung cancer by APE1 through regulation of epithelial-mesenchymal transition

Xi Wei _, Qing Li, Ying Li, Wei Duan, Chongbiao Huang, Xiangqian Zheng, Lei Sun, Jingtao Luo, Dong Wang, Sheng Zhang, Xiaojie Xin and Ming Gao

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Oncotarget. 2016; 7:28523-28539. https://doi.org/10.18632/oncotarget.8660

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Abstract

Xi Wei1,*, Qing Li2,*, Ying Li3,*, Wei Duan2, Chongbiao Huang4, Xiangqian Zheng7, Lei Sun5, Jingtao Luo6, Dong Wang2, Sheng Zhang1, Xiaojie Xin1, Ming Gao7

1Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

2Cancer Center, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, China

3The Third Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

4Department of Senior Ward, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

5Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

6The Department of Otorhinolaryngology and Maxillofacial Oncology, Tianjin Medical University Cancer Institute & Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin Cancer Institute, National Clinical Research Center of Cancer, Tianjin, China

7Department of Thyroid and Cervical Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

*These authors have contributed equally to this work

Correspondence to:

Sheng Zhang, email: [email protected]

Xiaojie Xin, email: [email protected]

Ming Gao, email: [email protected]

Keywords: non-small cell lung cancer (NSCLC), APE1, epithelial-mesenchymal transition (EMT), lymph node metastasis

Received: January 24, 2016     Accepted: March 28, 2016     Published: April 8, 2016

ABSTRACT

The DNA base excision repair gene APE1 involves in DNA damage repair pathway and overexpression in a variety of human cancers. Analyses of patients with non-small cell lung cancer (NSCLC) suggested that multiple factors associated with prognosis of NSCLC patients. Further investigation showed that APE1 expression was able to predict the progression-free survival and overall survival in patients with NSCLC and correlated with lymph node metastasis. Intriguingly, as a stratification of APE1-141 SNPs in APE1 positive expression, we also found APE1-141 GT/GG was identified as a marker for prediction of poor survival in NSCLC patients. In the in vitro experiments, the results showed that when APE1 expression was inhibited by siRNA or AT101 (an APE1 inhibitor), the migration and invasion of NSCLC cells were suppressed. Furthermore, epithelial-mesenchymal transition (EMT) markers was tested to provide evidence that APE1 promoted NSCLC EMT through interaction with SirT1. Using NSCLC xenograft models, we confirmed that AT101 shrank tumor volumes and inhibited lymph node metastasis. In conclusion, APE1 could be a potential target for patients with NSCLC metastasis and AT101 is a potent inhibitor in further treatment of NSCLC patients.


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