Oncotarget

Research Papers:

Sp1 and COX2 expression is positively correlated with a poor prognosis in pancreatic ductal adenocarcinoma

Junjie Hang, Hai Hu, Junjie Huang, Ting Han, Meng Zhuo, Yangyang Zhou, Lei Wang, Yi Wang, Feng Jiao _ and Liwei Wang

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Oncotarget. 2016; 7:28207-28217. https://doi.org/10.18632/oncotarget.8593

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Abstract

Junjie Hang1,2,*, Hai Hu1,2,*, Junjie Huang3,*, Ting Han1,2, Meng Zhuo1,2, Yangyang Zhou4, Lei Wang5, Yi Wang1,2, Feng Jiao1,2, Liwei Wang1,2

1Department of Medical Oncology and Pancreatic Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China

2Shanghai Key Laboratory of Pancreatic Disease, Shanghai 201620, China

3Department of Hematology, First Affiliated Hospital of Shenzhen University, Shenzhen 513000, China

4Department of Medical Oncology, First Affiliated Hospital of Bengbu Medical College, Anhui 233004, China

5Department of Radiation Oncology, Lianyungang First People’s Hospital, Jiangsu 222002, China

*These authors contributed equally to this work

Correspondence to:

Feng Jiao, email: [email protected]

Liwei Wang, email: [email protected]

Keywords: pancreatic ductal adenocarcinoma, specificity protein 1, cyclooxygenase-2, correlation, prognosis

Received: January 17, 2016    Accepted: March 28, 2016    Published: April 5, 2016

ABSTRACT

Previous studies showed that celecoxib, a cyclooxygenase-2 (COX2) inhibitor, can inhibit angiogenesis and metastasis of pancreatic ductal adenocarcinoma (PDAC) via the suppression of specificity protein 1 (Sp1). In this study, we investigated the prognostic value of Sp1 and COX2 in 88 PDAC patients. Our study showed there was a positive correlation between Sp1 and COX2 expression (P=0.001) by using the Spearman’s rank test. Pearson Chi-square test revealed that Sp1 and COX2 expression were positively associated with lymph node metastasis (P<0.05, both). In addition, the Kaplan–Meier analysis showed that patients with Sp1- or COX2-positive expression exhibited poorer overall survival (OS) than those with Sp1- or COX2-negative expression (P<0.05, all). Most importantly, Sp1- and COX2-negative patients had the best OS (P=0.01). In multivariate analysis, Sp1 expression (P=0.03), COX2 expression (P=0.04), and nuclear grade (P=0.009) were found to be independent predictors for OS. Moreover, we confirmed that Sp1 could upregulate the expression of COX2 in PDAC cell lines by western blot analysis, and both are of important prognostic value in PDAC.


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