Oncotarget

Research Papers:

Single-nucleotide polymorphisms in PSCA and the risk of breast cancer in a Chinese population

Meng Wang _, Xijing Wang, Sidney W. Fu, Xinghan Liu, Tianbo Jin, Huafeng Kang, Xiaobin Ma, Shuai Lin, Haitao Guan, Shuqun Zhang, Kang Liu, Cong Dai, Yuyao Zhu and Zhijun Dai

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Oncotarget. 2016; 7:27665-27675. https://doi.org/10.18632/oncotarget.8491

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Abstract

Meng Wang1, Xijing Wang1, Sidney W. Fu2, Xinghan Liu1, Tianbo Jin3, Huafeng Kang1, Xiaobin Ma1, Shuai Lin1, Haitao Guan1, Shuqun Zhang1, Kang Liu1, Cong Dai1, Yuyao Zhu1, Zhijun Dai1,2

1Department of Oncology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China

2Division of Genomic Medicine/Department of Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA

3National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, Xi’an 710069, China

Correspondence to:

ZhiJun Dai, e-mail: [email protected]; [email protected]

Keywords: PSCA, single-nucleotide polymorphisms, breast cancer, susceptibility

Received: December 07, 2015    Accepted: March 18, 2016    Published: March 30, 2016

ABSTRACT

This study explored the associations between common PSCA single-nucleotide polymorphisms (rs2294008, rs2978974, and rs2976392) and breast cancer among 560 breast cancer cases and 583 controls (Chinese Han women). We found rs2294008 was significantly associated with a high risk of breast cancer (homozygote model, odds ratio [OR]: 1.67, 95% confidence interval [CI]: 1.06–2.59; recessive, OR: 1.64, 95% CI: 1.06–2.53). And stratification by menopausal status revealed an association of the minor allele of rs2294008 with breast cancer risk among premenopausal (homozygote model, OR: 2.41, 95% CI: 1.03–5.66; recessive, OR: 2.80, 95 % CI: 1.21–6.47) and postmenopausal women (allele model, OR: 1.29, 95% CI: 1.01–1.65). Rs2978974 influenced the breast cancer risk among postmenopausal women in heterozygote model (OR: 1.47, 95% CI: 1.05–2.07). When stratified by clinicopathologic features, the T allele of rs2294008 was associated with progesterone receptor status (homozygote model, OR: 1.98, 95% CI: 1.08–3.63; recessive, OR: 1.87, 95% CI: 1.04–3.37), and the rs2976392 polymorphism was associated with high lymph node metastasis risk in homozygote model (OR: 2.09, 95%CI: 1.01–4.31). Further haplotype analysis suggested that Trs2294008 Ars2976392 Grs2978974 haplotype enhances breast cancer risk (OR:1.52, 95%CI:1.23-1.89, P<0.001). Therefore, among Chinese Han women, the PSCA rs2294008, rs2978974, and rs2976392 minor alleles are associated with increased breast cancer risk especially in progesterone receptor positive breast cancer patients, with breast cancer risk in postmenopausal women, and with high lymph node metastasis risk, respectively. Moreover, Trs2294008 Ars2976392 Grs2978974 haplotype was associated with significantly increased risk of breast cancer.


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