Clinical Research Papers:
Body mass index and cholesterol level predict surgical outcome in patients with hepatocellular carcinoma in Taiwan - a cohort study
Metrics: PDF 1452 views | HTML 1968 views | ?
Ya-Ling Lee1,2,3,*, Wan-Chun Li3,4,5,*, Tung-Hu Tsai5,6, Hsin-Yu Chiang4 and Chin-Tsung Ting6,7
1 Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan
2 Department of Dentistry, Taipei City Hospital, Taipei, Taiwan
3 Department of Dentistry, School of Dentistry, National Yang-Ming University, Taipei, Taiwan
4 Institute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei, Taiwan
5 Department of Education and Research, Taipei City Hospital, Taipei, Taiwan
6 Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
7 Division of Gastrointestinal Surgery, Department of Surgery, Ren-Ai Branch, Taipei City Hospital, Taipei, Taiwan
* These authors have contributed equally to this work
Chin-Tsung Ting, email:
Keywords: hepatocellular carcinoma, body mass index, serum cholesterol level, curative surgical resection, prognostic indicator
Received: September 21, 2015 Accepted: March 06, 2016 Published: March 24, 2016
Curative surgical resection (CSR) remains the most effective therapeutic intervention for patients with hepatocellular carcinoma (HCC); however, frequent post-surgical recurrence leads to high cancer related mortality. This study aimed to clarify the role of body mass index (BMI) and serum cholesterol level in predicting post-surgical outcomes in HCC patients after CSR. A total of 484 HCC patients including 213 BMIhigh and 271 BMIlow patients were included. Overall survival (OS) and recurrence-free survival (RFS) rates were examined in patients with differential BMI and serum cholesterol level. The analysis showed that significant different 1-, 3- and 5-year cumulative OS rates (P-value=0.015) and RFS rate (P-value=0.010) between BMIlow and BMIhigh patients. Further analysis in groups with differential serum cholesterol levels among BMIlow and BMIhigh patients indicated that the BMIlow/Chollow patients exhibited the significant lower cumulative OS and RFS rates in comparison with the remaining subjects (P-value=0.007 and 0.039 for OS and RFS rates, respectively). In conclusion, the coexistence of low BMI and low serum cholesterol level could serve as prognostic factors to predict post-operative outcomes in HCC patients undergoing surgical hepatectomy.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.