Oncotarget

Research Papers:

Nimotuzumab combined with concurrent chemoradiotherapy in locally advanced nasopharyngeal carcinoma: a retrospective analysis

Zhi-gang Liu _, Yu Zhao, Jiao Tang, Yu-juan Zhou, Wen-juan Yang, Yan-fang Qiu and Hui Wang

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Oncotarget. 2016; 7:24429-24435. https://doi.org/10.18632/oncotarget.8225

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Abstract

Zhi-gang Liu1,*, Yu Zhao1,*, Jiao Tang1,*, Yu-juan Zhou1, Wen-juan Yang1, Yan-fang Qiu1, Hui Wang1

1Key Laboratory of Translational Radiation Oncology, Department of Radiation Oncology, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China

*These authors have contributed equally to this work

Correspondence to:

Hui Wang, e-mail: wanghui710327@163.com

Zhi-gang Liu, e-mail: zhigangliu1983@hotmail.com

Keywords: NPC, nimotuzumab, chemoradiotherapy, EGFR

Received: October 22, 2015    Accepted: March 02, 2016    Published: March 21, 2016

ABSTRACT

Nimotuzumab is a blocking monoclonal antibody against epidermal growth factor receptor (EGFR). However, little is known about the safety and preliminary efficacy of nimotuzumab combined with concurrent chemoradiotherapy in locally advanced NPC patients. A total of 42 patients diagnosed between 2011 and 2013 were enrolled. Our results demonstrated 38 patients had a complete response (90.5%), 4 patients had a partial response (9.5%). And no patients had progressive disease at early treatment response evaluation, giving an ORR of 100%. The 2-year local recurrence-free survival (LRFS), distant metastasis-free survival (DMFS) and overall survival (OS) were 96.4%, 93.1% and 96.6% respectively. The most common adverse events were mucositis (19 patients), hematology toxicity (14 patients) with 6 and 3 cases of grade 3/4 toxicity respectively. Skin rash was not developed in our 43 patients. Thus, nimotuzumab combined with concurrent chemoradiotherapy showed encouraging outcomes in the treatment of locally advanced nasopharyngeal carcinoma, without accumulation of toxicity and well-tolerated.


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