Research Papers:

ZCWPW1 is associated with late-onset Alzheimer's disease in Han Chinese: a replication study and meta-analyses

Yu Gao, Meng-Shan Tan, Hui-Fu Wang, Wei Zhang, Zi-Xuan Wang, Teng Jiang, Jin-Tai Yu and Lan Tan _

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Oncotarget. 2016; 7:20305-20311. https://doi.org/10.18632/oncotarget.7945

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Yu Gao1,*, Meng-Shan Tan1,*, Hui-Fu Wang1, Wei Zhang2, Zi-Xuan Wang1, Teng Jiang3, Jin-Tai Yu1, Lan Tan1

1Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China

2Department of Emergency, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China

3Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, PR China

*These authors contributed equally to this work

Correspondence to:

Lan Tan, e-mail: [email protected]

Jin-Tai Yu, e-mail: [email protected], [email protected]

Keywords: ZCWPW1, rs1476679, polymorphism, Alzheimer's disease

Received: November 21, 2015     Accepted: February 09, 2016     Published: March 06, 2016


Recently, a large genome-wide association study (GWAS) has identified a novel variant (rs1476679) within ZCWPW1 showing strong association with late-onset Alzheimer's disease (LOAD) in Caucasian. However, the effect of rs1476679 on other populations remains unclear. In order to explore whether rs1476679 is also associated with the LOAD risk in other ethnic groups, we recruited 2350 unrelated Northern Han Chinese subjects, which include 992 LOAD patients and 1358 healthy controls. Analysis of data from these subjects suggests that the rs1476679 polymorphism is significantly associated with the LOAD (genotype P = 0.017, allele P = 0.044). The logistic regression reveals the C allele at rs1476679 is a protective factor for LOAD in the dominant model (OR = 0.779, 95%CI = 0.659–0.921, Pc = 0.009) adjusting for gender, age and APOE ε4 status. Furthermore, rs1476679 can decrease the AD risk (Dominant: OR = 0.733, 95%CI = 0.607–0.884, Pc = 0.006; Additive: OR = 0.820, 95%CI = 0.708–0.950, Pc = 0.048) in APOE ε4 non-carriers after stratification. Furthermore, meta-analysis of 82525 individuals confirmed that rs1476679 within ZCWPW1 decreased the risk of LOAD (OR = 0.91, 95%CI = 0.89–0.94). To summarize, the rs1476679 polymorphism in ZCWPW1 is associated with LOAD in Northern Han Chinese population.

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