Oncotarget

Research Papers:

CIP2A down regulation enhances the sensitivity of pancreatic cancer cells to gemcitabine

Peng Xu _, Jie Yao, Jin He, Long Zhao, Xiaodong Wang, Zhennan Li and Jianjun Qian

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Oncotarget. 2016; 7:14831-14840. https://doi.org/10.18632/oncotarget.7447

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Abstract

Peng Xu1,*, Jie Yao1,*, Jin He1, Long Zhao1, Xiaodong Wang1, Zhennan Li1, Jianjun Qian1

1Department of Hepatobiliary and Pancreatic Surgery, Northern Jiangsu People’s Hospital, Clinical medical college of Yangzhou University, Yangzhou city, Jiangsu Provence of P. R. China, 225001

*These authors have contributed equally to this work

Correspondence to:

Jie Yao, e-mail: [email protected]

Keywords: CIP2A, pancreatic ductal adenocarcinoma, gemcitabine, prognosis, overall survival

Received: November 03, 2015    Accepted: January 29, 2016    Published: February 17, 2016

ABSTRACT

Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein which participates in inhibiting tumor apoptosis in pancreatic cancer cells. Using immunohistochemical staining, we investigated the expression of CIP2A protein in 72 cases of human pancreatic ductal adenocarcinoma (PDAC) tissue and 27 cases of adjacent normal pancreatic tissue. The positive rate of CIP2A protein expression in pancreatic cancer tissue was70.83 %, which was significantly higher than that in adjacent non- cancerous pancreatic tissue (11.11%). The expression of CIP2A was found to be correlated with TNM stage, but not correlated with age, gender, tumor location, smoking status, alcohol consumption, diabetes, high blood pressure, BMI, tumor size, lymph node metastasis or distant metastases. Kaplan- Meier survival analysis showed that patients with positive CIP2A protein expression had a lower overall survival rate than patients without CIP2A expression. COX regression analysis indicated that expression of CIP2A was an independent prognostic factor for pancreatic ductal adenocarcinoma. In addition, down-regulation of CIP2A inhibited cell proliferation and increased sensitivity to gemcitabine in pancreatic cancer cells by decreasing AKT signaling pathway. Our results indicated that down-regulation of CIP2A could be a novel therapeutic strategy for pancreatic cancer


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